Patents by Inventor Tomas G. Kempe

Tomas G. Kempe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Calcitonin gene related peptide analogs with amino acid subdstituents at the penultimate position 36
    Patent number: 4697002
    Abstract: New calcitonin gene related peptide analogs (CGRP) are disclosed which have biological activity of the same type as known calcitonin gene related peptides and which have an amino acid substituent at position 36 or the penultimate position instead of the naturally occurring amino acid--Ala.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: September 29, 1987
    Inventor: Tomas G. Kempe
  • Calcitonin gene related peptide analogs with C-terminal D-amino acid substituents
    Patent number: 4687839
    Abstract: New calcitonin gene related peptide analogs (CGRP) are disclosed which have biological activity of the same type as known calcitonin gene related peptides and which have a D-amino acid substituent in at least one of the positions 36 and 37 instead of the natural L-amino acids.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: August 18, 1987
    Inventor: Tomas G. Kempe
  • Synthetic peptides with calcitonin-like activity
    Patent number: 4658014
    Abstract: New peptides are disclosed which have biological activity of the same type as calcitonins and which have been modified with desaminocysteine and .alpha.-aminosuberic acid at the N-terminal and new amino acid substituents at the penultimate position of the C-terminal.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: April 14, 1987
    Inventor: Tomas G. Kempe
  • Calcitonin analogs with C-terminal D-amino acid substituents
    Patent number: 4652627
    Abstract: New calcitonin analogs are disclosed which have biological activity of the same type as known calcitonins and which have a D-amino acid substituent in at least one of the positions 31 and 32 instead of the natural L-amino acid units. The calcitonin analog may be analogs of salmon, eel, chicken, bovine, porcine, ovine, murine or human calcitonins.
    Type: Grant
    Filed: August 16, 1985
    Date of Patent: March 24, 1987
    Inventors: Tomas G. Kempe, Flora Chow
  • Calcitonin analogs with amino acid substituents at position 31
    Patent number: 4644054
    Abstract: New polypeptides are disclosed which have biological activity of the same degree as known calcitonins and which have amino acid substituents in position 31 instead of the naturally occuring amino acids--Thr, Ala, Val.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: February 17, 1987
    Inventor: Tomas G. Kempe
  • Geminally disubstituted indene derivatives
    Patent number: 4218472
    Abstract: New geminally disubstituted indenes are of general formula I ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a direct bond or an alkylene group --(CH.sub.2).sub.n --, in which n is an integer from 1 to 4, R.sup.3 is hydrogen, C.sub.1-3 -alkoxy or halogen, and each of R.sup.4 and R.sup.5 is hydrogen or C.sub.1-4 -lower alkyl, or R.sup.4 and R.sup.5 together form an alkylene group --(CH.sub.2).sub.m --, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids.The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as vasocostrictor or as an anti-reserpine agent.The indenes may be prepared by processes known per se involving(a) synthesing the side chain --CH(OH)CH.sub.2 NR.sup.4 R.sup.
    Type: Grant
    Filed: August 1, 1978
    Date of Patent: August 19, 1980
    Assignee: AB Kabi
    Inventors: Aake N. Joensson, Tomas G. Kempe, Lembit Mikiver, Bengt A. Sparf