Patents by Inventor Tomas Maira-Litran

Tomas Maira-Litran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polysaccharide vaccine for staphylococcal infections
    Patent number: 10919956
    Abstract: The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo. The invention also relates to the use of dPNAG as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same class of infections.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: February 16, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Gerald B. Pier, Tomas Maira-Litran
  • Conjugation process for PNAG and a carrier protein
    Patent number: 8933218
    Abstract: The present application describes a process for conjugating a PNAG which is less than 40% N-acetylated to a carrier protein.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: January 13, 2015
    Assignee: GlaxoSmithKline Biologicals s.a.
    Inventors: Ralph Leon Biemans, Pierre Duvivier, Tomas Maira-Litran
  • Immunogenic composition
    Patent number: 8703148
    Abstract: The present application relates to immunogenic compositions comprising staphylococcal PNAG which is less than 40% N-acetylated and is conjugated to a carrier protein by a linker bonded to an amine group on PNAG to form a PNAG conjugate. Vaccines, methods of treatment using and processes to make an immunogenic composition comprising PNAG and Type 5 and/or 8 capsular polysaccharides are also described.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: April 22, 2014
    Assignee: GlaxoSmithKline Biologicals S.A
    Inventors: Ralph Leon Biemans, Philippe Denoel, Pierre Duvivier, Tomas Maira-Litran, Jan Poolman
  • IMMUNOGENIC COMPOSITION
    Publication number: 20100322959
    Abstract: The present application relates to immunogenic compositions comprising staphylococcal PNAG which is less than 40% N-acetylated and is conjugated to a carrier protein by a linker bonded to an amine group on PNAG to form a PNAG conjugate. Methods of using and processes to make an immunogenic composition are also described.
    Type: Application
    Filed: March 29, 2007
    Publication date: December 23, 2010
    Applicants: GLAXOSMITHKLINE BIOLOGICALS, S.A., The Brigham & Women's Hospital Inc.
    Inventors: Ralph Leon Biemans, Philippe Denoel, Pierre Duvivier, Tomas Maira-Litran, Jan Poolman
  • CONJUGATION PROCESS FOR PNAG AND A CARRIER PROTEIN
    Publication number: 20100303852
    Abstract: The present application describes a process for conjugating a PNAG which is less than 40% N-acetylated to a carrier protein.
    Type: Application
    Filed: March 29, 2007
    Publication date: December 2, 2010
    Inventors: Ralph Leon Biemans, Pierre Duvivier, Tomas Maira-Litran
  • Polysaccharide vaccine for staphylococcal infections
    Publication number: 20050118198
    Abstract: The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo. The invention also relates to the use of dPNAG as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same class of infections.
    Type: Application
    Filed: November 12, 2003
    Publication date: June 2, 2005
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Gerald Pier, Tomas Maira-Litran