Patents by Inventor Tomas Pekarek

Tomas Pekarek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutically acceptable cocrystals of N-[2-(7-methoxyl-1-naphtyl)ethyl]acetamide and methods of their preparation
    Patent number: 8927771
    Abstract: The present invention relates to novel solid forms of agomelatine (I), specifically novel phaamaceutically acceptable cocrystals thereof, as well as to methods of preparing them. Three pharmaceutically acceptable cocrystals of (I) that have physico-chemical properties acceptable for pharmaceutical development were obtained.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: January 6, 2015
    Assignee: Zentiva k.s.
    Inventors: Gary James Miller, Ludek Ridvan, Jindrich Richter, Ondrej Dammer, Tomas Chvojka, Tomas Pekarek, Winfried Heyse, Norbert Nagel
  • Salts of desvenlafaxine and a method of their preparation
    Patent number: 8779005
    Abstract: The invention deals with new salts of the desvenlafaxine base of formula (I) with oxalic acid, the new salts being the hydrogen oxalate of formula (II) in the proportion of desvenlafaxine:oxalic acid of 1:1 and hemioxalate of formula (III) in the proportion of desvenlafaxine:oxalic acid of 2:1.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: July 15, 2014
    Assignee: Zentiva k.s.
    Inventors: Ludek Ridvan, Petr Hruby, Stanislav Radl, Hana Brusova, Lukas Krejcik, Tomas Pekarek, Natalia Csokova, Anna Zerzanova
  • PHARMACEUTICALLY ACCEPTABLE COCRYSTALS OF N-[2-(7-METHOXYL-1-NAPHTYL)ETHYL]ACETAMIDE AND METHODS OF THEIR PREPARATION
    Publication number: 20140051887
    Abstract: The present invention relates to novel solid forms of agomelatine (I), specifically novel phaamaceutically acceptable cocrystals thereof, as well as to methods of preparing them. Three pharmaceutically acceptable cocrystals of (I) that have physico-chemical properties acceptable for pharmaceutical development were obtained.
    Type: Application
    Filed: April 25, 2012
    Publication date: February 20, 2014
    Inventors: Gary James Miller, Ludek Ridvan, Jindrich Richter, Ondrej Dammer, Tomas Chvojka, Tomas Pekarek, Winfried Heyse, Norbert Nagel
  • Method for the preparation of zolmitriptan
    Patent number: 8143417
    Abstract: In the preparation of zolmitriptan of formula III the reduction of the diazonium salt to (5)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one of formula IV is performed in a more concentrated mixture and by the effect on an alkali metal disulphite, preferably sodium disulphite. A zolmitriptan toluene solvate, characterized by a toluene content of 9 to 14% by weight according to the gas chromatography determination and by a maximum of the corresponding mass loss at temperatures of about 111° C. in the gravimetric analysis record. A zolmitriptan toluene solvate, showing strong Raman bands at the wave numbers of 1443 and 1354 cm?1, characteristic for the crystal lattice of zolmitriptan with built-in toluene, and further marked bands at 1004 and 786 cm?1, characteristic for toluene.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: March 27, 2012
    Assignee: Zentiva k.s.
    Inventors: Michal Voslar, Monika Zatopkova, Ludek Ridvan, Tomas Pekarek
  • NEW SALTS OF DESVENLAFAXINE AND A METHOD OF THEIR PREPARATION
    Publication number: 20120041227
    Abstract: The invention deals with new salts of the desvenlafaxine base of formula (I) with oxalic acid, the new salts being the hydrogen oxalate of formula (II) in the proportion of desvenlafaxine:oxalic acid of 1:1 and hemioxalate of formula (III) in the proportion of desvenlafaxine:oxalic acid of 2:1.
    Type: Application
    Filed: February 3, 2010
    Publication date: February 16, 2012
    Inventors: Ludek Ridvan, Petr Hruby, Stanislav Radl, Hana Brusova, Lukas Krejcik, Tomas Pekarek, Natalia Csokova, Anna Zerzanova
  • METHOD FOR THE PREPARATION OF ZOLMITRIPTAN
    Publication number: 20100105919
    Abstract: In the preparation of zolmitriptan of formula III the reduction of the diazonium salt to (5)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one of formula IV is performed in a more concentrated mixture and by the effect on an alkali metal disulphite, preferably sodium disulphite. A zolmitriptan toluene solvate, characterized by a toluene content of 9 to 14% by weight according to the gas chromatography determination and by a maximum of the corresponding mass loss at temperatures of about 111° C. in the gravimetric analysis record. A zolmitriptan toluene solvate, showing strong Raman bands at the wave numbers of 1443 and 1354 cm?1, characteristic for the crystal lattice of zolmitriptan with built-in toluene, and further marked bands at 1004 and 786 cm?1, characteristic for toluene.
    Type: Application
    Filed: February 25, 2008
    Publication date: April 29, 2010
    Inventors: Michal Voslar, Monika Zatopkova, Ludek Ridvan, Tomas Pekarek