Abstract: 5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.

Abstract: 5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.

Abstract: Systems, methods, apparatuses, and computer program products for node de-duplication. One method includes discovering, by a network monitoring apparatus, nodes in a network, and collecting a list of internet protocol (IP) addresses, media access control (MAC) addresses, domain name system (DNS) names, and sysnames for each of the nodes discovered in the network. The method may also include comparing the collected list of information for each of the discovered nodes with corresponding information for current nodes and other discovered nodes. The method may then includes determining duplicate nodes that are duplicates of the other discovered nodes and/or the current nodes based on the comparison of the IP addresses, MAC addresses, DNS names, and sysnames.

Abstract: Systems, methods, apparatuses, and computer program products for node de-duplication. One method includes discovering, by a network monitoring apparatus, nodes in a network, and collecting a list of internet protocol (IP) addresses, media access control (MAC) addresses, domain name system (DNS) names, and sysnames for each of the nodes discovered in the network. The method may also include comparing the collected list of information for each of the discovered nodes with corresponding information for current nodes and other discovered nodes. The method may then includes determining duplicate nodes that are duplicates of the other discovered nodes and/or the current nodes based on the comparison of the IP addresses, MAC addresses, DNS names, and sysnames.