Abstract: A method may determine transformation parameters for a transformation of a position of a vehicle between a first coordinate system and a second coordinate system. In the method, a trajectory may be traveled with the vehicle in a step. In another step, the positions of the vehicle while traveling the trajectory may be acquired in the first coordinate system with a first position detection system, and in the second coordinate system with a second position detection system. In a further step, transformation parameters between the coordinate systems may be derived based on the positions of the vehicle acquired in the coordinate systems, and based on at least one geometric parameter of the trajectory.

Abstract: A transmission which includes input and output shafts and first and second step-down devices for producing various step-down ratios. The first and second step-down devices are associated with first and second controllable clutches, respectively, in order to connect, in a torque-transmitting manner, the respective step-down device between the input shaft and the output shaft. A first gear of the transmission is obtained by actuating the first clutch and a second gear by actuating the second clutch. A method of controlling a gearshift, from the first gear to the second gear, includes the steps of determining operating condition parameters of the transmission; and determining optimized degrees of actuation of the clutches by a search process related to a transmission model that determines the degrees of actuation on the basis of operating condition parameters in relation to a predetermined optimization criterion. The transmission model is based on slip.

Abstract: A transmission which includes input and output shafts and first and second step-down devices for producing various step-down ratios. The first and second step-down devices are associated with first and second controllable clutches, respectively, in order to connect, in a torque-transmitting manner, the respective step-down device between the input shaft and the output shaft. A first gear of the transmission is obtained by actuating the first clutch and a second gear by actuating the second clutch. A method of controlling a gearshift, from the first gear to the second gear, includes the steps of determining operating condition parameters of the transmission; and determining optimized degrees of actuation of the clutches by a search process related to a transmission model that determines the degrees of actuation on the basis of operating condition parameters in relation to a predetermined optimization criterion. The transmission model is based on slip.

Abstract: A method of optimizing shifting of a shifting element which fixes a shaft to another component of the drive-train. Three shifting processes are influenced by respective characteristic forms of a control parameter. The first and second characteristic forms are different from one another. Each shifting process has a distinct start and end time (tBeginn, tEnde). The rotational speed of the shaft is a function n(t) of time t. An idealized rotational speed nideal(t):=G{n(t)} is determined by a filter G. First and second evaluation indexes I:=I(t??t,t)/I (tBeginn?t, tBeginn) are calculated, in which tBeginn<t?tEnde. I(ta, tb) is a measure of a deviation of the rotational speed n(t) from the idealized rotational speed nideal(t) over time [ta,tb]. The third characteristic form is chosen based on the first and second evaluation indexes I.

Abstract: A method of optimizing shifting of a shifting element which fixes a shaft to another component of the drive-train. Three shifting processes are influenced by respective characteristic forms of a control parameter. The first and second characteristic forms are different from one another. Each shifting process has a distinct start and end time (tBeginn, tEnde). The rotational speed of the shaft is a function n(t) of time t. An idealized rotational speed nideal(t):=G{n(t)} is determined by a filter G. First and second evaluation indexes I:=I(t??t,t)/I (tBeginn?t, tBeginn) are calculated, in which tBeginn<t?tEnde. I(ta, tb) is a measure of a deviation of the rotational speed n(t) from the idealized rotational speed nideal(t) over time [ta,tb]. The third characteristic form is chosen based on the first and second evaluation indexes I.

Abstract: Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

Abstract: Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

Abstract: Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.