Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.

Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.

Abstract: Systems for power conversion, and controllers and methods for operating a power converter. The method includes receiving high-side and low-side primary signals that drive primary transistors of a power converter. The method also includes receiving a combined drain voltage signal for high-side and low-side synchronous rectifier (SR) transistors of the power converter. The method further includes generating a high-side SR signal based on the low-side primary signal and generating a low-side SR signal based on the high-side primary signal. The method also includes determining high-side and low-side body diode conduction times based on the combined drain voltage signal. The method further includes adjusting the high-side SR signal based on the high-side body diode conduction time and adjusting the low-side SR signal based on the low-side body diode conduction time.

Abstract: Prodrugs of mebendazole and methods for their use in treating a disease, disorder, or disorder, including cancer, are disclosed.

Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA

Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.

Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.

Abstract: Synchronous rectification in active clamp flyback power converters. At least some example embodiments are methods including: sensing a first slope of voltage on a secondary winding of the transformer, the first slope indicative of the power converter entering a charge mode of the transformer; modifying, responsive the sensing, an operational state of a secondary rectifier (SR), driver coupled to a secondary rectifier; making the secondary rectifier conductive by the SR driver during a discharge mode of the transformer; sensing a second slope of voltage on the secondary of the transformer, the second slope indicative of ending of the discharge mode of the power converter; and then returning, responsive to sensing the second slope, the SR driver to an original operational state.

Abstract: Systems and methods are provided for monitoring a client device. An agent is configured to monitor a dynamic, user-defined set of key performance indicators by periodically polling the client device and generate messages including an aggregate value for a key performance indicator over a predefined period of time, and an identifier associated with the client device. A transaction manager accepts messages from the agent, provides a confirmation message to the agent indicating receipt of each message, and records the messages in a distributed ledger.

Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.

Abstract: Prodrugs of mebendazole and methods for their use in treating a disease, disorder, or disorder, including cancer, are disclosed.

Abstract: Synchronous rectification in active clamp flyback power converters. At least some example embodiments are methods including: sensing a first slope of voltage on a secondary winding of the transformer, the first slope indicative of the power converter entering a charge mode of the transformer; modifying, responsive the sensing, an operational state of a secondary rectifier (SR), driver coupled to a secondary rectifier; making the secondary rectifier conductive by the SR driver during a discharge mode of the transformer; sensing a second slope of voltage on the secondary of the transformer, the second slope indicative of ending of the discharge mode of the power converter; and then returning, responsive to sensing the second slope, the SR driver to an original operational state.

Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA

Abstract: Synchronous rectification in active clamp flyback power converters. At least some example embodiments are methods including: sensing, based on a rate of change of voltage on a drain of a synchronous rectifier field effect transistor (SR FET), that the power converter has entered a charge mode of a transformer arranged for flyback operation; changing, responsive the sensing, a parameter within a SR driver from an original state to a modified state, the SR driver coupled to the SR FET; making the SR FET conductive during a discharge mode of the transformer; sensing, based on a voltage at the drain of the SR FET, that the discharge mode of the converter has ended; returning, responsive to sensing that the discharge mode has ended, the parameter to the original state.

Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.

Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.

Abstract: A synchronous rectifier controller includes an exception timer, one or more blanking timers, and control logic. The control logic may detect a beginning of a conduction phase using a current sense signal. In response to detecting the beginning of the conduction phase, the control logic commences the exception timer, commences a first blanking interval, and asserts the drive signal. In response to an OFF condition being detected, the first blanking interval being elapsed, and the exception timer being running, the control logic de-asserts the drive signal and commences a second blanking interval. In response to an ON condition being detected, the second blanking interval being elapsed, and the exception timer being running, the control logic commences a third blanking interval and asserts the drive signal. The control logic may assert and de-assert the drive signal multiple times while the exception timer is running.

Abstract: A synchronous rectifier controller includes an exception timer, one or more blanking timers, and control logic. The control logic may detect a beginning of a conduction phase using a current sense signal. In response to detecting the beginning of the conduction phase, the control logic commences the exception timer, commences a first blanking interval, and asserts the drive signal. In response to an OFF condition being detected, the first blanking interval being elapsed, and the exception timer being running, the control logic de-asserts the drive signal and commences a second blanking interval. In response to an ON condition being detected, the second blanking interval being elapsed, and the exception timer being running, the control logic commences a third blanking interval and asserts the drive signal. The control logic may assert and de-assert the drive signal multiple times while the exception timer is running.

Abstract: A method and synchronous rectifier controller uses minimum off and on time blanking to avoid switching the switching transistor at incorrect times responsive to transients in the current sense signal. The minimum off time timer is commenced only when the current sense signal is above a reset threshold, and is reset when the current sense voltage falls below the reset threshold. Resetting the minimum off time timer in this manner avoids false starts of the minimum off time timer due to transients and allows the SRC to properly synchronize with the conduction and blocking phases of rectifier operation.

Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.