Patents by Inventor Tomaso Zambelli

Tomaso Zambelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11047057
    Abstract: A method for manufacturing a three-dimensional object comprises the steps of (a) bringing at least one nozzle in a first position close to a surface of a substrate, (b) delivering through said at least one nozzle at least one reactant to said surface, (c) effecting a solid forming reaction of said at least one delivered reactant such that said at least one delivered reactant undergoes a transition to become a growing solid deposit on said surface under said at least one nozzle, and (d) detecting an interaction of said growing solid deposit with said at least one nozzle.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: June 29, 2021
    Assignee: Exaddon AG
    Inventors: Janos Vörös, Tomaso Zambelli, Luca Hirt, Stephan Ihle
  • Publication number: 20190048486
    Abstract: A method for manufacturing a three-dimensional object comprises the steps of (a) bringing at least one nozzle in a first position close to a surface of a substrate, (b) delivering through said at least one nozzle at least one reactant to said surface, (c) effecting a solid forming reaction of said at least one delivered reactant such that said at least one delivered reactant undergoes a transition to become a growing solid deposit on said surface under said at least one nozzle, and (d) detecting an interaction of said growing solid deposit with said at least one nozzle.
    Type: Application
    Filed: September 28, 2016
    Publication date: February 14, 2019
    Applicant: ETH Zurich
    Inventors: Janos VÖRÖS, Tomaso ZAMBELLI, Luca HIRT, Stephan IHLE
  • Patent number: 9910030
    Abstract: Small and extremely small molecules and ions or atoms may be detected with the novel device with exceptional sensitivity. The detection is implemented in a simple manner by the known acoustic resonator FBAR or by means of other technologies that measure the physical properties of the filled layer. The permeability of substances (e.g. active ingredients) through membranes such as cell membranes, lipid bilayers, and cell walls can be examined by combining a sensor with the reservoir and the membrane.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: March 6, 2018
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Martin Nirschl, Kaori Sugihara, Janos Vörös, Tomaso Zambelli
  • Patent number: 8986626
    Abstract: The invention relates to a probe arrangement (10g) for exchanging in a controllable way liquids with micro-sized samples of material like biological cells, especially in connection with an scanning probe microscope, said probe arrangement (10g) comprising a probe holder (11) with at least one embedded first channel (18) and a cantilever (12) with at least one embedded second channel (15) and being provided to be attached to said probe holder (11) in a way that at least one aperture (19) of the first channel (18) is connected to at least one aperture (17) of the second channel (15) in a way that permits the liquid-tight transfer of a liquid between said first and second channels (15, 18). A safe and easy use of the probe arrangement is achieved by having the cantilever (12) permanently attached to said probe holder (11) to form a prefabricated probe unit (10g).
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: March 24, 2015
    Assignee: ETH Zürich / ETH Transfer
    Inventors: Michael Gabi, Janos Vörös, Tomaso Zambelli, Pascal Behr
  • Publication number: 20120176601
    Abstract: A method for measuring transport properties of cell membranes or lipid bilayers by providing at least a substrate having a topside and a backside and plurality of nano- or micro-pores and a cell membrane covering the plurality of pores being accessible from both sides of the cell membrane for measurement, a material layer at least in the region of the pores to support the cell membrane at the pores but not hindering the transport through the cell membrane and the pores arranged on the substrate, either on the topside or on the backside, applying a fluid containing at least one molecule to the topside of the membrane in order to allow the molecule to move through the membrane, one of the pores and the material layer, and monitoring of the molecules having passed the material layer by using an optical detection method.
    Type: Application
    Filed: December 15, 2011
    Publication date: July 12, 2012
    Applicant: LEISTER PROCESS TECHNOLOGIES
    Inventors: Janos VOEROES, Marco DI BERARDINO, Kaori SUGIHARA, Tomaso ZAMBELLI
  • Publication number: 20120164716
    Abstract: Small and extremely small molecules and ions or atoms may be detected with the novel device with exceptional sensitivity. The detection is implemented in a simple manner by the known acoustic resonator FBAR or by means of other technologies that measure the physical properties of the filled layer. The permeability of substances (e.g. active ingredients) through membranes such as cell membranes, lipid bilayers, and cell walls can be examined by combining a sensor with the reservoir and the membrane.
    Type: Application
    Filed: January 9, 2012
    Publication date: June 28, 2012
    Applicants: SIEMENS AKTIENGESELLSCHAFT, ETH ZURICH
    Inventors: MARTIN NIRSCHL, KAORI SUGIHARA, JANOS VÖRÖS, TOMASO ZAMBELLI
  • Publication number: 20110124027
    Abstract: The invention relates to a probe arrangement (10g) for exchanging in a controllable way liquids with micro-sized samples of material like biological cells, especially in connection with an scanning probe microscope, said probe arrangement (10g) comprising a probe holder (11) with at least one embedded first channel (18) and a cantilever (12) with at least one embedded second channel (15) and being provided to be attached to said probe holder (11) in a way that at least one aperture (19) of the first channel (18) is connected to at least one aperture (17) of the second channel (15) in a way that permits the liquid-tight transfer of a liquid between said first and second channels (15, 18). A safe and easy use of the probe arrangement is achieved by having the cantilever (12) permanently attached to said probe holder (11) to form a prefabricated probe unit (10g).
    Type: Application
    Filed: July 24, 2009
    Publication date: May 26, 2011
    Applicant: ETH Zurich / ETH Transfer
    Inventors: Michael Gabi, Janos Vörös, Tomaso Zambelli, Pascal Behr
  • Patent number: 7870616
    Abstract: A probe arrangement with a probe for local electrophysiological analysis of cells (4) such as patch-clamp techniques for use with atomic force microscopy, has a probe with a cantilever arm (2) connected to a probe holder (3). The probe has a probe tip (4) at a probing end (5) of the cantilever arm (2) and a fluid channel (6) in the cantilever arm (2) connecting a probe tip aperture (7) with a fluid reservoir (8) via a duct (9). The fluid channel (6), the duct (9) and the fluid reservoir (8) are adapted to be filled with a fluid solution (10) enabling ion transport for electrophysiological analysis. A first electrode (15) for electrophysiological analysis is placed in the fluid reservoir (8) and/or in the duct (9) and/or in the fluid channel (6).
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: January 11, 2011
    Assignee: CSEM Centre Suisse D'Electronique Et de Microtechnique SA
    Inventors: André Meister, Jérôme Polesel-Maris, Michael Gabi, Tomaso Zambelli, Janos Vörös
  • Publication number: 20080302960
    Abstract: A probe arrangement with a probe for local electrophysiological analysis of cells (4) such as patch-clamp techniques for use with atomic force microscopy, has a probe with a cantilever arm (2) connected to a probe holder (3). The probe has a probe tip (4) at a probing end (5) of the cantilever arm (2) and a fluid channel (6) in the cantilever arm (2) connecting a probe tip aperture (7) with a fluid reservoir (8) via a duct (9). The fluid channel (6), the duct (9) and the fluid reservoir (8) are adapted to be filled with a fluid solution (10) enabling ion transport for electrophysiological analysis. A first electrode (15) for electrophysiological analysis is placed in the fluid reservoir (8) and/or in the duct (9) and/or in the fluid channel (6).
    Type: Application
    Filed: May 9, 2008
    Publication date: December 11, 2008
    Inventors: Andre Meister, Jerome Polesel-Maris, Michael Gabi, Tomaso Zambelli, Janos Voros