Patents by Inventor Tomasz Herjan

Tomasz Herjan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SBE APTAMERS FOR TREATING IL-17a RELATED DISEASES AND CONDITIONS
    Publication number: 20230009539
    Abstract: Provided herein are compositions, systems, kits, and methods for treating IL-17a related diseases and conditions using an SBE nucleic acid sequence that binds a SEFIR domain of an ACT1 protein.
    Type: Application
    Filed: June 6, 2022
    Publication date: January 12, 2023
    Inventors: Xiaoxia Li, Tomasz Herjan, Lingzi Hong, Donna Marie Driscoll, Caini Liu
  • Transgenic mice with inducible neuron-specific inactivation of HuR gene and method of screening
    Patent number: 11382316
    Abstract: Provided herein non-human transgenic animals comprising a genome that: i) under-expresses, or is inducible to under-express, Hu Antigen R (HuR) in at least some neurons of said transgenic animal; ii) does not express HuR, or is inducible to not express HuR, in at least some neurons of said transgenic animal; or iii) does not express functional HuR, or is inducible to not express functional HuR in at least some neurons of said transgenic animal, as well as methods of screening drugs and therapies (e.g., useful in treating ALS) using such animals.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: July 12, 2022
    Assignee: The Cleveland Clinic Foundation
    Inventors: Xiaoxia Li, Tomasz Herjan, Kevin Sun, Xing Chen
  • SBE aptamers for treating IL-17a related diseases and conditions
    Patent number: 11352630
    Abstract: Provided herein are compositions, systems, kits, and methods for treating IL-17a related diseases and conditions using an SBE nucleic acid sequence that binds a SEFIR domain of an ACT1 protein.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: June 7, 2022
    Inventors: Xiaoxia Li, Tomasz Herjan, Lingzi Hong, Donna Marie Driscoll, Caini Liu
  • SBE APTAMERS FOR TREATING IL-17a RELATED DISEASES AND CONDITIONS
    Publication number: 20200157544
    Abstract: Provided herein are compositions, systems, kits, and methods for treating IL-17a related diseases and conditions using an SBE nucleic acid sequence that binds a SEFIR domain of an ACT1 protein.
    Type: Application
    Filed: July 19, 2018
    Publication date: May 21, 2020
    Inventors: Xiaoxia Li, Tomasz Herjan, Lingzi Hong, Donna Marie Driscoll, Caini Liu
  • NEURON-SPECIFIC HuR-DEFICIENT OR INDUCIBLE HuR-DEFICIENT ANIMAL MODELS
    Publication number: 20200015461
    Abstract: Provided herein non-human transgenic animals comprising a genome that: i) under-expresses, or is inducible to under-express, Hu Antigen R (HuR) in at least some neurons of said transgenic animal; ii) does not express HuR, or is inducible to not express HuR, in at least some neurons of said transgenic animal; or iii) does not express functional HuR, or is inducible to not express functional HuR in at least some neurons of said transgenic animal, as well as methods of screening drugs and therapies (e.g., useful in treating ALS) using such animals.
    Type: Application
    Filed: June 19, 2019
    Publication date: January 16, 2020
    Inventors: Xiaoxia Li, Tomasz Herjan, Kevin Sun, Xing Chen