Patents by Inventor Tomasz Kula

Tomasz Kula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BINDING PROTEINS RECOGNIZING HA-1 ANTIGEN AND USES THEREOF
    Publication number: 20230398217
    Abstract: Provided herein are binding proteins recognizing HA-1 antigen and uses thereof.
    Type: Application
    Filed: November 8, 2021
    Publication date: December 14, 2023
    Inventors: Ribhu Nayar, Gavin MacBeath, Sonal Jangalwe, Mollie M. Jurewicz, Andrew S. Basinski, Qikai Xu, Antoine J. Boudot, Tomasz Kula
  • SARS-COV-2 IMMUNODOMINANT PEPTIDE CONSTRUCTS AND USES THEREOF
    Publication number: 20230398205
    Abstract: Provided herein are methods and compositions for the treatment and/or prevention of COVID-19 through the induction of an immune response against identified SARS-COV-2 immunodominant peptides.
    Type: Application
    Filed: November 12, 2021
    Publication date: December 14, 2023
    Inventors: Tomasz KULA, Gavin MacBeath, Andrew P. Ferretti
  • Methods and compositions for identifying epitopes
    Patent number: 11834653
    Abstract: Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: December 5, 2023
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Stephen Elledge, Tomasz Kula, Mohammad Haj Dezfulian
  • Detection of an antibody against a pathogen
    Patent number: 11821110
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: November 21, 2023
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
  • BINDING PROTEINS RECOGNIZING SARS-COV-2 ANTIGENS AND USES THEREOF
    Publication number: 20230287079
    Abstract: Provided herein are binding proteins recognizing SARS-CoV-2 antigens and uses thereof.
    Type: Application
    Filed: July 20, 2021
    Publication date: September 14, 2023
    Inventors: Tomasz Kula, Given MacBeath, Andrew P. Ferretti, Yifan Wang
  • COMPOSITIONS AND METHODS FOR IDENTIFYING EPITOPES
    Publication number: 20230287390
    Abstract: Provided herein are methods and compositions for identifying epitopes by using reporters of phospholipid scramblase.
    Type: Application
    Filed: July 20, 2021
    Publication date: September 14, 2023
    Inventors: Yifan WANG, Andrew P. Ferretti, Nancy Nabilsi, Gavin MacBeath, Tomasz Kula
  • SARS-COV-2 IMMUNODOMINANT PEPTIDES AND USES THEREOF
    Publication number: 20230241205
    Abstract: Provided herein are methods and compositions for the treatment and/or prevention of COVID-19 through the induction of an immune response against identified SARS-COV-2 immunodominant peptides.
    Type: Application
    Filed: June 17, 2021
    Publication date: August 3, 2023
    Inventors: Tomasz Kula, Gavin MacBeath, Andrew P. Ferretti, Yifan Wang
  • DETECTION OF AN ANTIBODY AGAINST A PATHOGEN
    Publication number: 20220251541
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
    Type: Application
    Filed: January 25, 2022
    Publication date: August 11, 2022
    Applicants: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Stephen J. ELLEDGE, Harry B. LARMAN, Tomasz KULA, George XU
  • DETECTION OF AN ANTIBODY AGAINST A PATHOGEN
    Publication number: 20200333356
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 22, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
  • Detection of an antibody against a pathogen
    Patent number: 10768181
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof. One aspect provided herein relates to a method for detecting an antibody against a pathogen in a subject, the method comprising: (a) contacting a reaction sample comprising a display library with a biological sample comprising antibodies, wherein the display library comprises a plurality of peptides derived from a plurality of pathogens, and (b) detecting a peptide bound to at least one antibody, thereby detecting an antibody capable of binding the peptide.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: September 8, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
  • METHODS AND COMPOSITIONS FOR IDENTIFYING EPITOPES
    Publication number: 20200102553
    Abstract: Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.
    Type: Application
    Filed: June 8, 2018
    Publication date: April 2, 2020
    Inventors: Stephen Elledge, Tomasz Kula, Mohammad Haj Dezfulian
  • DETECTION OF AN ANTIBODY AGAINST A PATHOGEN
    Publication number: 20190055545
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
    Type: Application
    Filed: January 27, 2017
    Publication date: February 21, 2019
    Applicants: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Stephen J. ELLEDGE, Harry B. LARMAN, Tomasz KULA, George XU
  • A ROAD BARRIER AND A METHOD FOR CONTROLLING THEREOF
    Publication number: 20160362857
    Abstract: A road barrier comprising a guide (110) mounted on a row of supporting elements (120) by means of booms (130), the barrier being characterized in that between the guide (110) and the supporting elements (120) there are mounted containers (150) with fluid configured to absorb the energy of impacts between the guide (110) and the supporting elements.
    Type: Application
    Filed: March 11, 2015
    Publication date: December 15, 2016
    Inventors: TOMASZ KULA, Tadeusz DZIENIS, Ewa WICHER, Dawid KUCHARSKI, Michal KARKOWSKI, Krzysztof ROZEWICZ, Daniel KASZOWSKI, Krysztof KAZIMIERSKI, Krysztof PILARSKI
  • DETECTION OF AN ANTIBODY AGAINST A PATHOGEN
    Publication number: 20160320406
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof. One aspect provided herein relates to a method for detecting an antibody against a pathogen in a subject, the method comprising: (a) contacting a reaction sample comprising a display library with a biological sample comprising antibodies, wherein the display library comprises a plurality of peptides derived from a plurality of pathogens, and (b) detecting a peptide bound to at least one antibody, thereby detecting an antibody capable of binding the peptide.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 3, 2016
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu