Patents by Inventor Tomasz Rzymski

Tomasz Rzymski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole derivatives as kinase inhibitors
    Patent number: 10174013
    Abstract: The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of PIM1-3- and DYRK1A-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e.g. leukemias, lymphomas, solid tumors and autoimmune disorders.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: January 8, 2019
    Assignee: SELVITA S.A.
    Inventors: Wojciech Czardybon, Krzysztof Brzózka, Michal Galezowski, Renata Windak, Mariusz Milik, Magdalena Zawadzka, Pawel Guzik, Ewelina Wincza, Marta Prokop, Katarzyna Wiklik, Aleksandra Sabiniarz, Wieslaw Marek Cholody, Raymond Horvath, Tomasz Rzymski
  • PYRIDONE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20180305331
    Abstract: Disclosed in the present application is a compound of formula (I) as defined herein as well as a pharmaceutical composition comprising said compound. Further disclosed in the present application is the use of such pharmaceutical compositions for treating diseases, namely inter alia for use in the treatment of cancer, metabolic, inflammatory, autoimmune and viral diseases. The compounds disclosed herein are inhibitors of MNK1 and/or MNK2 kinases.
    Type: Application
    Filed: October 20, 2016
    Publication date: October 25, 2018
    Applicant: SELVITA S.A.
    Inventors: Tomasz RZYMSKI, Mariusz MILIK, Krzysztof BRZOZKA, Charles-Henry FABRITIUS, Katarzyna KUCWAJ-BRYSZ, Urszula KULESZA, Ewelina WINCZA, Agnieszka DREAS, Michal GALEZOWSKI
  • Substituted tricyclic benzimidazoles as kinase inhibitors
    Patent number: 9745299
    Abstract: Disclosed are substituted tricyclic benzimidazoles compounds as defined herein in formula (I) or pharmaceutically acceptable salts thereof. The compounds of the invention selectively inhibit CDK8 and are therefore useful for treating diseases related to this kinase, especially colorectal and melanoma cancers and other solid and hemathological malignancies, autoimmune diseases and inflammatory diseases. Also disclosed are processes for preparing these compounds.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: August 29, 2017
    Assignee: SELVITA SA
    Inventors: Tomasz Rzymski, Adrian Zarebski, Agnieszka Dreas, Karolina Osowska, Katarzyna Kucwaj, Joanna Fogt, Marek Cholody, Michal Galezowski, Wojciech Czardybon, Raymond Horvath, Katarzyna Wiklik, Mariusz Milik, Krzysztof Brzózka
  • NOVEL BENZIMIDAZOLE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20170152249
    Abstract: The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of PIM1-3- and DYRK1A-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e.g. leukemias, lymphomas, solid tumors and autoimmune disorders.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 1, 2017
    Inventors: Wojciech CZARDYBON, Krzysztof Brzózka, Michal Galezowski, Renata Windak, Mariusz Milik, Magdalena Zawadzka, Pawel Guzik, Ewelina Wincza, Marta Prokop, Katarzyna Wiklik, Aleksandra Sabiniarz, Wieslaw Marek Cholody, Raymond Horvath, Tomasz Rzymski
  • Benzimidazole derivatives as Kinase Inhibitors
    Patent number: 9388192
    Abstract: The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of PIM1-3- and DYRK1A-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e.g. leukemias, lymphomas, solid tumors and autoimmune disorders.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 12, 2016
    Assignee: Selvita S.A.
    Inventors: Wojciech Czardybon, Krzysztof Brzózka, Michal Galezowski, Renata Windak, Mariusz Milik, Magdalena Zawadzka, Pawel Guzik, Ewelina Wincza, Marta Prokop, Katarzyna Wiklik, Aleksandra Sabiniarz, Wieslaw Marek Cholody, Raymond Horvath, Tomasz Rzymski
  • Novel Benzimidazole Derivatives as Kinase Inhibitors
    Publication number: 20150336967
    Abstract: The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of PIM1-3- and DYRK1A-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e.g. leukemias, lymphomas, solid tumors and autoimmune disorders.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 26, 2015
    Inventors: Wojciech CZARDYBON, Kraków BRZÓZKA, Michal GALEZOWSKI, Renata WINDAK, Mariusz MILIK, Magdalena ZAWADZKA, Pawel GUZIK, Ewelina WINCZA, Marta PROKOP, Katarzyna WIKLIK, Aleksandra SABINIARZ, Wieslaw Marek CHOLODY, Raymond HORVATH, Tomasz RZYMSKI
  • SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS
    Publication number: 20150274726
    Abstract: Disclosed are substituted tricyclic benzimidazoles compounds as defined herein in formula (I) or pharmaceutically acceptable salts thereof. The compounds of the invention selectively inhibit CDK8 and are therefore useful for treating diseases related to this kinase, especially colorectal and melanoma cancers and other solid and hemathological malignancies, autoimmune diseases and inflammatory diseases. Also disclosed are processes for preparing these compounds.
    Type: Application
    Filed: November 7, 2013
    Publication date: October 1, 2015
    Inventors: Tomasz Rzymski, Adrian Zarebski, Agnieszka Dreas, Karolina Osowska, Katarzyna Kucwaj, Joanna Fogt, Marek Cholody, Michal Galezowski, Wojciech Czardybon, Raymond Horvath, Katarzyna Wiklik, Mariusz Milik, Krzysztof Brzózka