Patents by Inventor Tomasz SLEZAK

Tomasz SLEZAK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYPEPTIDES FOR DETECTION AND TREATMENT OF SARS-COV-2
    Publication number: 20240059760
    Abstract: Aspects of the present disclosure relate to polypeptides that specifically bind to a SARS-CoV-2 spike protein, and to methods of use for treatment, prevention, and diagnosis of a SARS-CoV-2 infection. Certain aspects are directed to antibodies and fragments thereof, including Fabs, configured to bind to various epitopes within the receptor binding domain (RBD) of a SARS-CoV-2 spike protein. Compositions, kits, and methods for detection of SARS-CoV-2 are also disclosed.
    Type: Application
    Filed: November 1, 2021
    Publication date: February 22, 2024
    Applicant: The University of Chicago
    Inventors: Anthony KOSSIAKOFF, Tomasz SLEZAK
  • METHODS AND COMPOSITIONS COMPRISING MODIFIED FAB SCAFFOLDS AND PROTEIN G FAB BINDING DOMAINS
    Publication number: 20240043534
    Abstract: The engineered polypeptide comprising modified Fab constant regions and/or protein G Fab binding domains provide advanced affinity reagents that can be used in cell biology applications as well as for therapeutic applications. Accordingly, aspects of the disclosure relate to a polypeptide comprising a constant region of an antibody light chain, wherein the constant region comprises a substitution/deletion of amino acids corresponding to positions 16-20 of SEQ ID NO:1 of the constant region with the amino acids LRT.
    Type: Application
    Filed: October 14, 2020
    Publication date: February 8, 2024
    Applicant: The University of Chicago
    Inventors: Anthony KOSSIAKOFF, Tomasz SLEZAK, Elena DAVYDOVA, Edwin ARAUZ-DIAZ
  • METHODS AND COMPOSITIONS FOR TARGETING LIVER AND LYMPH NODE SINUSOIDAL ENDOTHELIAL CELL C-TYPE LECTIN (LSECTIN)
    Publication number: 20210171642
    Abstract: Certain embodiments are directed to compositions and methods for targeting an antigen to a liver and lymph node C type lectin (LSECtin). In particular aspects the compositions disclosed herein can induce tolerogenic immunity to the targeted antigen.
    Type: Application
    Filed: March 26, 2019
    Publication date: June 10, 2021
    Applicant: The University of Chicago
    Inventors: Jeffrey HUBBELL, Elyse A. WATKINS, Tomasz SLEZAK