Abstract: Arrays comprising probes comprising probes from more than one influenza strain or subtype are provided. Methods of using the arrays, as well as kits and systems comprising the arrays are also provided.

Abstract: Arrays comprising probes comprising peptides from more than one flavivirus are provided. Methods of using the arrays, as well as kits and systems comprising the arrays are also provided.

Abstract: Methods of reducing immunogenicity of an antibody are provided, as are methods of producing a second antibody from a first. Polypeptide and antibody sequences are also provided.

Abstract: The claimed subject matter provides systems and/or methods that facilitate generating population sequences of strain variants included in a sample. Sequencing can be based on high throughput of short reads. Further, site variants exhibited in the short reads can be linked to reconstruct multiple full strains of a targeted gene, including low concentration variants in the sample. Cues in the short read data can be utilized to perform multi-strain assembly. For example, the cues can include different strain concentrations that lead to more frequently seen strains being responsible for more frequent reads and quilting of overlapping reads to infer mutation linkage over long stretches of DNA.