Abstract: A system and method that allows for control of an on-screen keyboard in response to brain activity input, even for those suffering from partial paralysis or locked-in syndrome. The system provides an on-screen keyboard arranged into blocks of keys for ease of navigation. In response to brain activity input, such as activity relating to thoughts or facial expressions, the system performs a variety of previously determined functions which control the on-screen keyboard. In response to the activity of the on-screen keyboard, the computer can be controlled in a manner similar to when using a standard hand-operated keyboard.