Patents by Inventor Tomer Shlomi

Tomer Shlomi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11826353
    Abstract: The invention provides a method for treating cancer in which a level of reduced folate carrier (RFC) or folylpolyglutamate synthetase (FPGS) in cancer cells of the biopsy is determined. If the level of RFC or FPGS in the cancer cells is below a threshold value, the cancer is treated with an inhibitor of serine-hydroxymethyl-transferase (SHMT)1. If the level of RFC or FPGS in the cancer cells is above the threshold value, the cancer is treated with an inhibitor of SHMT2.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: November 28, 2023
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Tomer Shlomi, Won Dong Lee
  • Publication number: 20220088079
    Abstract: Provided herein are nanoparticles encapsulating a required substance for enriching immune cells with the required substance, compositions comprising the same and methods for their preparation. Further provided are methods of using the nanoparticles for enriching the immune cells with the required substance as well as methods of treating cancer using the nanoparticles or compositions comprising the same.
    Type: Application
    Filed: November 18, 2021
    Publication date: March 24, 2022
    Inventors: Tomer SHLOMI, Abraham RUTENBERG
  • Publication number: 20210077462
    Abstract: The invention provides a method for treating cancer in which a level of reduced folate carrier (RFC) or folylpolyglutamate synthetase (FPGS) in cancer cells of the biopsy is determined. If the level of RFC or FPGS in the cancer cells is below a threshold value, the cancer is treated with an inhibitor of serine-hydroxymethyltransferase (SHMT)1.
    Type: Application
    Filed: September 18, 2020
    Publication date: March 18, 2021
    Inventors: Tomer SHLOMI, Won Dong LEE
  • Publication number: 20160300010
    Abstract: A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all previously deleted non-core reactions results in inhibition of any of the core reactions or results in inhibition of the flux of biomass metabolites to biomass is determined. If inhibition of the k-th non-core reaction and inhibition of all previously deleted non-core reactions does not result in inhibition of any core reactions and does not result in inhibition of the flux of biomass metabolites to biomass, then the k-th non-core reaction is deleted from the set of non-core reactions. The number of permutations for which the k-th non-core reaction is not deleted is determined and a metabolic map is then created based on that number.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 13, 2016
    Inventors: Eytan Ruppin, Tomer SHLOMI, Ori FOLGER, Eyal GOTTLIEB, Christian FREZZA
  • Publication number: 20120283956
    Abstract: A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all previously deleted non-core reactions results in inhibition of any of the core reactions or results in inhibition of the flux of biomass metabolites to biomass is determined. If inhibition of the k-th non-core reaction and inhibition of all previously deleted non-core reactions does not result in inhibition of any core reactions and does not result in inhibition of the flux of biomass metabolites to biomass, then the k-th non-core reaction is deleted from the set of non-core reactions. The number of permutations for which the k-th non-core reaction is not deleted is determined and a metabolic map is then created based on that number.
    Type: Application
    Filed: March 2, 2012
    Publication date: November 8, 2012
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., Cancer Research Technology Limited, Technion Research and Development Foundation Ltd.
    Inventors: Eytan RUPPIN, Tomer Shlomi, Ori Folger, Eyal Gottlieb, Christian Frezza