Patents by Inventor Tomi K. Sawyer

Tomi K. Sawyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120115783
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: May 10, 2012
    Applicant: Alleron therapeutics, Inc
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120101047
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: April 26, 2012
    Applicant: Aileron Therapetics Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
    Patent number: 8114874
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: February 14, 2012
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Dong Zou, Wei-Sheng Huang, R. Mathew Thomas, Jan Antionette C. Romero, Jiwei Qi, Yihan Wang, Xiaotian Zhu, William C. Shakespeare, Rajeswari Sundaramoorthi, Chester A. Metcalf, III, David C. Dalgarno, Tomi K. Sawyer
  • Unsaturated heterocyclic derivatives
    Patent number: 8071609
    Abstract: This invention relates to compounds of the general formula: in which Q is an ethynyl or ethenyl moiety; Ring A is an aryl, heteroaryl or heterocyclic ring or ring system; and the remaining variable groups are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 6, 2011
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Wei-Sheng Huang, Rajeswari Sundaramoorthi, Xiaotian Zhu, R. Mathew Thomas, William C. Shakespeare, David C. Dalgarno, Tomi K. Sawyer
  • Biologically Active Peptidomimetic Macrocycles
    Publication number: 20110144303
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 13, 2009
    Publication date: June 16, 2011
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
    Publication number: 20100298201
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: November 24, 2009
    Publication date: November 25, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20100216688
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 22, 2009
    Publication date: August 26, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Llbermann, Tomi K. Sawyer
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20090326192
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: April 8, 2009
    Publication date: December 31, 2009
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Therapeutic peptidomimetic macrocycles
    Publication number: 20090275519
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: February 9, 2009
    Publication date: November 5, 2009
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • Acetylenic Heteroaryl Compounds
    Publication number: 20090176781
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: May 8, 2007
    Publication date: July 9, 2009
    Inventors: Yihan Wang, Xiaotian Zhu, Rajeswari Sundaramoorthi, Wei-Sheng Huang, Dong Zhu, R. Mathew Thomas, Jiwei Qi, Jan Antoinette C. Romero, David C. Dalgarno, William C. Shakespeare, Tomi K. Sawyer, Chester A. Metcalf, III
  • Unsaturated Heterocyclic Derivatives
    Publication number: 20090156596
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: August 11, 2006
    Publication date: June 18, 2009
    Inventors: Yihan Wang, Wei-Sheng Huang, Rajeswari Sundaramoorthi, Xiaotian Zhu, R. Mathew Thomas, William C. Shakespeare, David C. Dalgarno, Tomi K. Sawyer
  • Monocyclic Heterocyclic Compounds
    Publication number: 20090149471
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: May 8, 2007
    Publication date: June 11, 2009
    Inventors: William C. Shakespeare, Wei-Sheng Huang, David C. Dalgarno, Xiaotian Zhu, R. Matthew Thomas, Yihan Wang, Jiwei Qi, Rajeswari Sundaramoorthi, Dong Zou, Chester A. Metcalf, III, Tomi k. Sawyer, Jan Antoinette C. Romero
  • Quinazolines and uses thereof
    Patent number: 7132427
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 7, 2006
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Purine derivatives
    Patent number: 7115589
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. In these compounds, RB is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety which comprises one or more phosphorus-containing moieties.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: October 3, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Manfred Weigele, Tomi K. Sawyer, Regine Bohacek, William C. Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David C. Dalgarno, Chester A. Metcalf, III
  • Quinolinones and uses thereof
    Patent number: 7019139
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 28, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Quinolines and uses thereof
    Patent number: 7009054
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 7, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Indolinones and uses thereof
    Patent number: 6960572
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RE, p, q and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 1, 2005
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: William C. Shakespeare, Tomi K. Sawyer, Chester A. Metcalf, III, Yihan Wang, Regine Bohacek
  • Phenylamino-pyrimidines and uses thereof
    Patent number: 6878697
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC, RD, w, x, y, and z are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: April 12, 2005
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF
    Publication number: 20040242611
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: December 2, 2004
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • Novel quinolinones and uses thereof
    Publication number: 20040167101
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): 1
    Type: Application
    Filed: November 17, 2003
    Publication date: August 26, 2004
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi