Patents by Inventor Tomi Sawyer

Tomi Sawyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long-acting co-agonists of the glucagon and GLP-1 receptors
    Patent number: 11492385
    Abstract: Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: November 8, 2022
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Anandan Palani, Ravi Nargund, Paul E. Carrington, Tomi Sawyer, Qiaolin Deng, Antonello Pessi, Elisabetta Bianchi, Federica Orvieto
  • LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS
    Publication number: 20200392196
    Abstract: Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
    Type: Application
    Filed: August 26, 2020
    Publication date: December 17, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Anandan Palani, Ravi Nargund, Paul E. Carrington, Tomi Sawyer, Qiaolin Deng, Antonello Pessi, Elisabetta Bianchi, Federica Orvieto
  • Long-acting co-agonists of the glucagon and GLP-1 receptors
    Patent number: 10793615
    Abstract: Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 6, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Anandan Palani, Ravi Nargund, Paul E. Carrington, Tomi Sawyer, Qiaolin Deng, Antonello Pessi, Elisabetta Bianchi, Federica Orvieto
  • LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS
    Publication number: 20190338008
    Abstract: Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
    Type: Application
    Filed: October 21, 2016
    Publication date: November 7, 2019
    Inventors: Anandan Palani, Ravi Nargund, Paul E. Carrington, Tomi Sawyer, Qiaolin Deng, Antonello Pessi, Elisabetta Bianchi, Federica Orvieto
  • Bicyclic heteroaryl compounds
    Publication number: 20070191376
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 16, 2007
    Inventors: Dong Zou, Wei-Sheng Huang, R. Thomas, Jan Romero, Jiwei Qi, Yihan Wang, Xiaotian Zhu, William Shakespeare, Rajeswari Sundaramoorthi, Chester Metcalf,, David Dalgarno, Tomi Sawyer
  • Novel perines
    Publication number: 20050096298
    Abstract: Novel purines and uses of these compounds for the treatment of bone related disorders and cancer is disclosed.
    Type: Application
    Filed: November 22, 2004
    Publication date: May 5, 2005
    Inventors: Chester Metcalf, Manfred Weigele, Tomi Sawyer, Regine Bohacek, William Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David Dalgarno
  • Substituted purine derivatives
    Publication number: 20050065171
    Abstract: This invention relates to compounds of the general formula: in which Y, RA, RC and R6 are as defined herein, and to their preparation and use.
    Type: Application
    Filed: June 24, 2004
    Publication date: March 24, 2005
    Inventors: William Shakespeare, Chester Metcalf, Tomi Sawyer, Yihan Wang, Rajeswari Sundaramoorthi, David Dalgarno, Regine Bohacek, Manfred Weigele
  • Sulfonamide substituted aspartic acid interleukin-1.beta. converting enzyme inhibitors
    Patent number: 6083981
    Abstract: The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula I, II, or III. ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: July 4, 2000
    Assignee: Warner-Lambert Company
    Inventors: Hamish John Allen, Kenneth Dale Brady, William Glen Harter, Elizabeth Ann Lunney, Mark Stephen Plummer, Tomi Sawyer, Aurash Shahripour, Nigel Walker
  • Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins
    Patent number: 5922697
    Abstract: The present invention provides compounds that inhibit the binding of proteins containing an SH2 domain to cognate phosphorylated proteins. The invention also provides pharmaceutical compositions containing the compounds and methods of inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: July 13, 1999
    Assignee: Warner-Lambert Company
    Inventors: Elizabeth A. Lunney, Kimberly S. Para, Mark S. Plummer, Josyula V. N. V. Prasad, Alan R. Saltiel, Tomi Sawyer, Aurash Shahripour, Juswinder Singh, Charles J. Stankovic
  • Pyrone derivatives as protease inhibitors and antiviral agents
    Patent number: 5808062
    Abstract: The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: September 15, 1998
    Assignee: Warner-Lambert Company
    Inventors: John Michael Domagala, Edmund Lee Ellsworth, Elizabeth Lunney, Daniel Fred Ortwine, Kimberly Suzanne Para, Josyula Venkata Nagendra Vara Prasad, Tomi Sawyer, Bradley Dean Tait
  • Sulfhydryl containing peptides for treating vascular disease
    Patent number: 5786335
    Abstract: Sulfhydryl containing peptides having the formulaX--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --Yinhibit the formation of Lp(a) and thus are useful for treating vascular diseases such as coronary heart disease, myocardial infarction, ischemic stroke, cervical atherosclerosis, cerebral infarction, and restenosis.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: July 28, 1998
    Assignee: Warner-Lambert Company
    Inventors: Wayne Livingston Cody, Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Tomi Sawyer, Drago Robert Sliskovic
  • Substituted tetra- and pentapeptide inhibitors of protein: farnesyl transferase
    Patent number: 5763577
    Abstract: Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: June 9, 1998
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, Alfred Campbell, Richard Gowan, John Cooke Hodges, Donald Hupe, Daniele Leonard, Tomi Sawyer, Judith Sebolt-Leopold, Francis J. Tinney
  • Isothiazolones lower plasma levels of lipoprotein(a)
    Patent number: 5668162
    Abstract: Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: September 16, 1997
    Inventors: John Michael Domagala, Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Tomi Sawyer, Drago Robert Sliskovic