Patents by Inventor Tomio Takeuchi

Tomio Takeuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Actinonin derivatives and pharmaceutically acceptable salts thereof
    Patent number: 5206384
    Abstract: A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: April 27, 1993
    Assignees: Zaidan Hojin Biseibutsu Kagaku Kai, Meiji Seika Kaisha Ltd.
    Inventors: Seiji Shibahara, Yoshiyuki Koyama, Shigeharu Inoue, Mitsugu Hachisu, Shinichi Kondo, Takaaki Aoyagi, Tomio Takeuchi
  • Poststatin and related compounds or salts thereof
    Patent number: 5162500
    Abstract: A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.
    Type: Grant
    Filed: December 7, 1990
    Date of Patent: November 10, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Takaaki Aoyagi, Masa Hamada, Hiroshi Naganawa, Keiji Ogawa, Machiko Nagai, Yasuhiko Muraoka, Makoto Tsuda
  • Pharmaceutical composition and method for angiogenesis inhibition
    Patent number: 5134156
    Abstract: Actinonin or a salt thereof is active as an inhibitor of angiogenesis in a mammal and is useful as a therapeutic agent for inhibiting angiogenesis in a mammal having diabetic retinopathy or inflammatory response accompanied by angiogenesis.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: July 28, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kai
    Inventors: Takao Iwaguchi, Mariko Shimamura, Shingo Uchida, Takaaki Aoyagi, Tomio Takeuchi
  • Pharmaceutical composition for inhibiting infection with virus causative of acquired human immunodeficiency syndrome
    Patent number: 5120717
    Abstract: Pharmaceutical compositions containing at least one of benanomicins A and B and their salts are now provided, which are useful to inhibit the infection of human T-cells with HIV, namely a virus causative of acquired human immunodeficiency syndrome (AIDS). Thus, benanomicins A and B as well as their salts are useful as antiviral agent against HIV.
    Type: Grant
    Filed: August 16, 1989
    Date of Patent: June 9, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Shinichi Kondo, Hiroo Hoshino
  • Physiologically active substances, benastatins A and B, and production and use thereof
    Patent number: 5117052
    Abstract: Benastatins A and B which are novel and physiologically active substances having the formula ##STR1## wherein R represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, exhibit a potent immunomodifier activity, a glutathione transferase inhibition activity and an anti-microorganism activity and are therefore extremely useful for various drugs.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: May 26, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Takaaki Aoyagi, Hiroshi Naganawa, Masa Hamada, Yasuhiko Muraoka, Takayuki Aoyama
  • Antibiotics, dexylosylbenanomicin B
    Patent number: 5109122
    Abstract: Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: April 28, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Takeshi Hara, Masa Hamada, Shinichi Kondo, Masaji Sezaki, Haruo Yamamoto, Shuichi Gomi
  • Mycaminosyl tylonolide derivatives
    Patent number: 5101022
    Abstract: Mycaminosyl tylonolide derivatives represented by the following general formula ##STR1## (wherein R.sup.1 denotes hydroxyl group, a lower alkanoyloxy group, benzoyloxy group, azido group, or amino group which may optionally be substituted with a lower alkyl or a lower alkanoyl radical; R.sup.2 stands for hydrogen atom or hydroxyl group; R.sup.3 expresses hydrogen atom or formyl group; and means a double bond or a radical represented by ##STR2## and salts thereof.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: March 31, 1992
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Tomio Takeuchi, Akihiro Tanaka, Shuichi Sakamoto
  • Carcinostatic or antitumor antibiotic, conagenin, and production and uses thereof
    Patent number: 5098935
    Abstract: A new antibiotic, named Conagenin, is provided which can exhibit useful carcinostatic or antitumor activities on carcinomas and tumors, particularly malignant tumors, of mammalian animals including man. Conagenin can be produced by fermentation of microorganisms of genus Streptomyces, typically Streptomyces roseosporus MI696-AF3 strain identified under the deposit number FERM BP-2738. Conagenin has formula (I) and is useful for medicinal purposes, particularly as carcinostatic agent or antitumor agent for inhibiting carcinomas and malignant tumors of mammalian animals, including man.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: March 24, 1992
    Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Masaaki Ishizuka, Takashi Yamashita, Hiroshi Naganawa, Hironobu Iinuma, Kunio Isshiki, Masa Hamada, Kenji Maeda, Tomio Takeuchi
  • 3-deoxy mycaminosyl tylonolide derivatives
    Patent number: 5096888
    Abstract: 3-Deoxy mycaminosyl tylonolide derivatives represented by the following general formula and salts thereof: ##STR1## wherein X represents an oxygen atom or .dbd.N--OR.sup.4 (wherein R.sup.4 represents hydrogen or lower alkyl); R.sup.1 represents a hydrogen atom, an acyl group or an alkylsilyl group; R.sup.2 represents a hydrogen atom or an acyl group; and R.sup.3 represents a hydrogen atom or a hydroxyl group. The compounds of this invention of the formula (I) are novel compounds and have excellent antibacterial activity.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: March 17, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyikai
    Inventors: Sumio Umezawa, Tsutomu Tsuchiya, Tomio Takeuchi, Shunji Kageyama, Shuichi Sakamoto
  • Anticancer antibiotic MI43-37F11 substance
    Patent number: 5096924
    Abstract: As a new antibiotic is provided a compound, now nominated as MI43-37F11 substance, which has formula ##STR1## This MI43-37F11 substance has an antitumor activity, an activity to enhance the production of interleukin-1 in vivo in a mammalian, and an activity to activate a macrophage in vivo in a mammalian. MI43-37F11 substance may be produced by cultivation of Streptoverticillium eurocidicum MI43-37F11 strain identified as FERM BP-2783.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: March 17, 1992
    Assignee: 501 Azidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Masaaki Ishizuka, Hiroyuki Kumagai, Tsutomu Sawa, Hiroshi Naganawa, Hironobu Iinuma, Kunio Isshiki, Masa Hamada, Kenji Maeda, Tomio Takeuchi
  • Antibiotic N-acetylbenanomicin B, and the production and uses thereof
    Patent number: 5093323
    Abstract: As a new compound is now provided N-acetylbenanomicin B which is useful as an antifungal agent and also as antiviral agent for inhibiting infection of human T-cell with HIV, namely a virus causative of acquired human immunodeficiency syndrome. N-acetylbenanomicin B may be prepared by acetylation of 4"-amino group of benanomicin B which is fermentatively produced by a new microorganism, MH193-16F4 strain of actinomycetes.
    Type: Grant
    Filed: December 29, 1989
    Date of Patent: March 3, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Shinichi Kondo, Shuichi Gomi, Hiroo Hoshino
  • Angolamycin derivatives
    Patent number: 5091370
    Abstract: An angolamycin derivative represented by the following formula ##STR1## wherein X represents an acetyl, methanesulfonyl, methylthio, benzoyl or methoxy group. This compound is useful as a medicament such as antibacterial agent and an animal feed additive.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: February 25, 1992
    Assignee: Sanraku Incorporated
    Inventors: Takeo Yoshioka, Azuma Watanabe, Koichiro Kominato, Hiroshi Tone, Rokuro Okamoto, Tsutomu Sawa, Tomio Takeuchi
  • Antifungal and antiviral antibiotic, benanomicin A 4"'-O-sulfate or its salt, and the production and uses thereof
    Patent number: 5091371
    Abstract: As a new antifungal and antiviral antibiotic is provided benanomicin A 4"'-O-sulfate or a salt thereof having formula (I) ##STR1## wherein M.sup.1 denotes a mono-valent alkali metal atom or a di-valent alkaline earth metal atom or a hydrogen atom and A denotes an organic base; n is zero when M.sup.1 is an alkali metal atom or alkaline earth metal atom but n is 1 or zero when M.sup.1 is a hydrogen atom, and M.sup.2 denotes a hydrogen atom or an alkali metal atom or an alkaline earth metal atom. This new compound is useful as antifungal agent to treat fungal infections in mammals and as antiviral agent to inhibitingly treat HIV.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: February 25, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Shinichi Kondo, Daishiro Ikeda
  • Benanomicins A and antibiotic compositions
    Patent number: 5055453
    Abstract: Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.
    Type: Grant
    Filed: October 31, 1988
    Date of Patent: October 8, 1991
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Takeshi Hara, Masa Hamada, Shinichi Kondo, Masaji Sezaki, Haruo Yamamoto, Shuichi Gomi
  • Process for producing 2,6-dideoxy-2-fluoro-L-talopyranose
    Patent number: 5034517
    Abstract: 2,6-Dideoxy-2-fluoro-L-talopyranose and 1-substituted derivatives thereof, including methyl 2,6-dideoxy-2-fluoro-L-talopyranoside and 3,4-di-O-protected-2,6-dideoxy-2-fluoro-L-talopyranosyl halides, are now provided and these new compounds are useful as intermediates for use in the synthesis of new compounds having antitumor activity, especially 7-O-(2,6-dideoxy-2-fluoro-.alpha.-L-talopyranosyl) daunomycinone or -adriamycinone. 2,6-Dideoxy-2-fluoro-L-talopyranose shows antibacterial activity. 2,6-Dideoxy-fluoro-L-talopyranose and the 1-substituted derivatives thereof may be produced by a multi-stage process starting from L-fucose.
    Type: Grant
    Filed: March 6, 1990
    Date of Patent: July 23, 1991
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Tomio Takeuchi, Yasushi Takagi
  • Physiologically active substances, probestin and prostatin and production thereof
    Patent number: 5021549
    Abstract: New physiologically active substances, named probestin and prostatin, respectively, are produced from a new microorganism, Streptomyces azureus MH663-2F6 strain identified as FERM P-9541 or FERM BP-1963. Probestin and prostatin have an activity inhibitory to aminopeptidase M and also have immunopotentiating properties.
    Type: Grant
    Filed: August 16, 1988
    Date of Patent: June 4, 1991
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Takaaki Aoyagi, Masa Hamada, Hiroshi Naganawa, Shigemi Yoshida
  • Method for relieving radiogenic or drug-induced side effects
    Patent number: 5002756
    Abstract: An agent for relieving radiogenic or drug-induced side effects, characterized by comprising a spergualin derivative of the following formula (I):NH.sub.2 --C(.dbd.NH)--NH--R.sub.1 --R.sub.2 --CONH--R.sub.3 --CONH--(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.3 --NH--Xwherein R.sub.1 represents --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.6 ##STR1## R.sub.2 represents --(CH.sub.2).sub.2 -- or --CH.dbd.CH--, R.sub.3 represents --(CH(OH)--CH(OMe)--, --CH.sub.2 -- or --(CH.sub.2).sub.m --CH(OH)--(CH.sub.2).sub.n -- (m represent an integer of 0,1 or 2 and n represents an integer of 1 or 2)X represents a hydrogen atom or a group formed by removing a hydroxyl group from a carboxyl group of an amino acid,or a pharmacologically acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: March 26, 1991
    Assignee: Zaidanhojin Biseibutsu Kagakukenkyukai
    Inventors: Kyuichi Nemoto, Tetsushi Saino, Tomio Takeuchi, Teruya Nakamura
  • Anthracycline derivatives having inhibitory activity against reverse transcriptase of human immunodeficiency virus
    Patent number: 5003055
    Abstract: As new compounds are now provided 14-O-(3,4-disubstituted benzoyl)adriamycins which are of low cytotoxicity and exhibit a high activity inhibitory to the reverse transcriptase of human immunodeficiency virus (HIV) and which can inhibit propagation of HIV.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: March 26, 1991
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Shinichi Kondo, Daishiro Ikeda, Yoshiyuki Koyama, Keiichi Ajito, Kazuo Umezawa, Sonoko Hirose
  • N-(4-(3-aminopropyl)aminobutyl)-2-(.omega.-gua nidino-fatty-acid-amido(-2-substituted-ethanamide, salt thereof, and process for preparation thereof
    Patent number: 4983328
    Abstract: N-[4-(3-Aminopropyl)aminobutyl]-2-(.omega.-guanidino-fatty acid-amido)-2-substituted-ethanamides represented by the general formula ##STR1## wherein Y represents --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH or ##STR2## R represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms which may have a hydroxyl group as substituent, or a benzyl group, and n is an integer of from 1 to 8, provided that when Y is ##STR3## and n is 4, R represents the groups other than the hydrogen atom; salt thereof having antitumor activity in experimental animal tumors and a process for the preparation thereof is provided.
    Type: Grant
    Filed: March 15, 1988
    Date of Patent: January 8, 1991
    Assignee: Bristol-Myers Company
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Hironobu Iinuma, Daishiro Ikeda, Teruya Nakamura, Akio Fujii
  • Novel spergualin-related compounds and process for producing the same
    Patent number: 4956504
    Abstract: The present invention relates to novel Spergualin-related compounds represented by the general formula [I] ##STR1## (wherein X is ##STR2## R is --H or --CH.sub.2 OH; R.sub.1 is --H, ##STR3## R.sub.2 is a residue obtained by removing, from an amino acid or peptide, the hydroxyl group of the carboxyl group and, when R.sub.1 is a group other than --H, R.sub.2 is same as R.sub.1), or a pharmacologically acceptable salt thereof. Said compounds or salts thereof have an immuno-modulating action.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: September 11, 1990
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Tetsushi Saino, Masao Yoshida, Katsutoshi Takahashi, Teruya Nakamura, Hamao Umezawa, deceased