Abstract: A coated cutting tool and a method to manufacture, and the use of the same is provided. The coated cutting tool includes of a substrate and a coating including a physical vapor deposition (PVD) deposited Ti,Al-based nitride layer having a thickness of at least 1.0 ?m. The PVD deposited Ti,Al-based nitride layer has at least one layer of TiAlN. The coating further includes a CVD deposited layer of TiN located between the substrate and the PVD deposited Ti,Al-based nitride layer. The CVD deposited layer of TiN is in contact with both the substrate and the PVD deposited Ti,Al-based nitride layer. The method for manufacturing a coated cutting tool includes growing a TiN layer by CVD on the substrate, and growing a Ti,Al-based nitride layer by PVD on the TiN layer.

Abstract: A method is described for initiating a wireless network to connect an electronic device among a set of first-type electronic devices with a second-type electronic device. The method comprising: receiving, at a service server configured to service the set of first-type electronic devices, data pertaining to a user-id; retrieving, from a database, a unique network configuration associated with the user-id, wherein the unique network configuration is known beforehand by the second-type electronic device; selecting, at the service server, an electronic device among the set of first-type electronic devices; and sending, to the selected electronic device, the unique network configuration associated with the user-id for allowing the selected electronic device to initiate a wireless network using the unique network configuration associated with the user-id.

Abstract: Disclosed is a stroller chassis with a hub. The stroller chassis comprises a first frame assembly and a second frame assembly. The hub is configured to couple the first frame assembly to the second frame assembly pivotably about a pivot axis and releasably lockably with respect to each other. The hub is configured to detachably and lockably support a carrying structure on the chassis. The hub is configured to support the carrying structure relative to the chassis pivotably about the pivot axis and lockably in a rotational position. Also disclosed is a stroller chassis with a hub. The hub is configured to detachably and lockably support a carrying structure on the chassis. The hub is configured such that fully unlocking the carrying structure from said hub to allow detachment may be caused by operation of only one release member.

Abstract: An expandable stent (1) to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery (100) with a stenosis (102) formed therein by plaque with a bore (103) therethrough. The expandable stent (1) comprises first and second end portions (3,4) joined by a central portion (5). The central portion (5) is configured in the expanded state of the stent (1) to be located in the bore (103) of the stenosis (102) with the first and second end portions (3,4) abutting non-diseased parts (104,106) of the artery (100) adjacent the proximal and distal ends (105,107) of the stenosis (102) for anchoring the stent (1) in the artery (100). The central portion (5) with the stent (1) in the expanded state is configured to apply a radial outward pressure to the stenosis (102) such that the diameter of the bore (103) of the stenosis (102) is maintained at its current diameter or increased to approximately 50% of the non-diseased parts (104,106) of the artery (100).

Abstract: An expandable stent to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery with a stenosis formed therein by plaque with a bore therethrough. The expandable stent includes first and second end portions and a central portion. The central portion is configured in the expanded state of the stent to contact the stenosis with the first and second end portions anchoring the stent in the artery.

Abstract: A WNT5A peptide or derivatives thereof in combination with one or more checkpoint inhibitors for use in treatment of cancer in a subject in need thereof. Furthermore, WNT5A peptides or derivatives thereof may be used in treatment of cancer in a subject, wherein the subject is responsive to immune checkpoint inhibitors.

Abstract: The present disclosure relates to a load carrier for a vehicle having a lid and a base connected along at least one edge by at least one hinge. The at least one hinge includes a first connection member and a second connection member. The first connection member is configured to be pivotably connected to the base or lid at a first proximal end, by a first pivotable connection, and the hinge is releasably connected to the base or lid via the first pivotable connection by a lock member. The second connection member is connected to the other one of the base or lid at a second proximal end. The hinge is configured such that when the lid is opened by pivoting the first connection member with respect to the pivot axle, a distance between the first proximal end and the second proximal end increases.

Abstract: A stick vacuum cleaner having a handheld vacuum cleaner adapted to be docked to a stick. When the handheld vacuum cleaner is docked to the stick an air path is formed connecting an air outlet of the handheld vacuum cleaner with an air outlet provided in the stick. A noise absorption unit is provided in the air path or outside the air outlet from the stick.

Abstract: An expandable stent to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery with a stenosis formed therein by plaque with a bore therethrough. The expandable stent includes first and second end portions joined by a central portion. The central portion is configured in the expanded state of the stent to be located in the bore of the stenosis with the first and second end portions abutting non-diseased parts of the artery adjacent the proximal and distal ends of the stenosis for anchoring the stent in the artery. The central portion with the stent in the expanded state is configured to apply a radial outward pressure to the stenosis such that the diameter of the bore of the stenosis is maintained at its current diameter or increased to approximately 50% of the non-diseased parts of the artery.

Abstract: An expandable stent (1) to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery (100) with a stenosis (102) formed therein by plaque with a bore (103) therethrough. The expandable stent (1) comprises first and second end portions (3,4) joined by a central portion (5). The central portion (5) is configured in the expanded state of the stent (1) to be located in the bore (103) of the stenosis (102) with the first and second end portions (3,4) abutting non-diseased parts (104,106) of the artery (100) adjacent the proximal and distal ends (105,107) of the stenosis (102) for anchoring the stent (1) in the artery (100). The central portion (5) with the stent (1) in the expanded state is configured to apply a radial outward pressure to the stenosis (102) such that the diameter of the bore (103) of the stenosis (102) is maintained at its current diameter or increased to approximately 50% of the non-diseased parts (104,106) of the artery (100).

Abstract: A stick vacuum cleaner having a handheld vacuum cleaner adapted to be docked to a stick. When the handheld vacuum cleaner is docked to the stick an air path is formed connecting an air outlet of the handheld vacuum cleaner with an air outlet provided in the stick. A noise absorption unit is provided in the air path or outside the air outlet from the stick.

Abstract: The present invention relates to a Wnt5a protein or peptide thereof possessing Wnt5a signaling properties, such as Foxy5, for use in the treatment of prostate cancer, in particular in patients that have undergone or will undergo radical prosteatectomy. The invention also relates to a method for determining a prognosis for a patient having prostate cancer and a kit for performing said method. The method for determining a prognosis for a patient comprises the steps of: evaluating an amount of Wnt5a protein present in at least part of a sample earlier obtained from the patient and determining a sample value corresponding to the evaluated amount; comparing the sample value obtained in step a) with a reference value associated with a reference prognosis; and, if said sample value is higher than said reference value, concluding that the prognosis for said patient is better than said reference prognosis.

Abstract: The present disclosure relates to a vacuum cleaner comprising an electric motor 3 and a blower producing an air flow through the vacuum cleaner. The electric motor and the blower are placed on a common vertical axis 17. A separator unit 13 is placed laterally with respect to the common axis of the motor and the blower. A bent conduit 19 connects the blower with the separator unit, and one end 21 of the conduit encloses the common vertical axis. The conduit comprises a portion located along the common axis 17 having a double wall forming a closed air pocket 23. This provides damping of noise emitted by the blower/motor and which propagates in the opposite direction of the air flow.

Abstract: The present invention relates to a Wnt5a protein or peptide thereof possessing Wnt5a signaling properties, such as Foxy5, for use in the treatment of prostate cancer, in particular in patients that have undergone or will undergo radical prosteatectomy. The invention also relates to a method for determining a prognosis for a patient having prostate cancer and a kit for performing said method. The method for determining a prognosis for a patient comprises the steps of: evaluating an amount of Wnt5a protein present in at least part of a sample earlier obtained from the patient and determining a sample value corresponding to the evaluated amount; comparing the sample value obtained in step a) with a reference value associated with a reference prognosis; and, if said sample value is higher than said reference value, concluding that the prognosis for said patient is better than said reference prognosis.

Abstract: Loss of Wnt-5a protein expression in breast carcinoma patients is associated with a shorter recurrence-free survival as well as increased motility in mammary cell lines. Based on sequence analysis of Wnt-5a, peptide fragments were identified and investigated for their ability to mimic effects of the Wnt-5a protein on mammary cell adhesion and motility. Two of these peptides significantly increased adhesion and impaired the motility of non-tumorigenic breast cancer cell lines, both low in endogenous Wnt-5a protein expression. To identify the shortest possible peptide that still had an anti-motile effect, sequential deletions of two amino acids from the N-terminal side of the shorter of these two peptides were performed. The effect on tumor cell adhesion was gradually lost, and when only 6 amino acids remained the effect was not detectable. However, formulation of the N-terminal methionine of this hexapeptide restored its effect on adhesion and reduced tumor cell motility.

Abstract: A reactor shield including a plurality of closed loops of electrically conductive wires arranged around a reactor.

Abstract: A method for stabilizing a weapon, eg a rifle or a handgun, barrel movements when aiming by attenuating the influence of, primarily, unintentional barrel movements on the barrel orientation. The method is especially characterized in the steps of providing a hinge (3) between the barrel front part (1), which comprises the barrel (1?), and the weapon rear part (2), which comprises the weapon butt end (2?), for mutual movability between said parts; continuously detecting the barrel longitudinal direction movement in at least two planes; and controlling at least one angle between the butt end and the barrel longitudinal direction orientation, respectively, by means of a control system (4h, 4v, 5h, 5v, 6h,6v) so that changes in the barrel orientation are counteracted. The invention also relates to a device and a fire arm.

Abstract: The present invention relates to a novel unbranched carbamate derivative, in particular N-butyloxycarbonyl derivative of certain Wnt5-? peptides and to their use in the treatment of melanoma or gastric cancer, as well as a method for treating melanoma as well as a pharmaceutical composition comprising the same derivative.

Abstract: A filter for an HVDC system. The filter includes a capacitor and a reactor arranged in an indoor location having a first space for erecting filter components. The first space includes a high voltage area and a low voltage area defining a first electric potential direction.

Abstract: The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface. An information carrier is applied to or distributed with the device, having direct or indirect volume information about defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by using at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.