Patents by Inventor Tommy Lok Man LO

Tommy Lok Man LO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinational use of mechanical manipulation and programin derivatives to increase Oct4, Sox2, Nanog or c-Myc expression in fibroblasts
    Patent number: 10676720
    Abstract: The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: June 9, 2020
    Assignee: The Chinese University of Hong Kong
    Inventors: Kenneth Ka Ho Lee, Tommy Lok Man Lo, Hoi Hung Cheung, Wai Yee Chan
  • COMBINATIONAL USE OF MECHANICAL MANIPULATION AND PROGRAMIN TO GENERATE PLURIPOTENT STEM CELLS FROM SOMATIC CELLS
    Publication number: 20190161738
    Abstract: The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).
    Type: Application
    Filed: November 19, 2018
    Publication date: May 30, 2019
    Inventors: Kenneth Ka Ho LEE, Tommy Lok Man LO, Hoi Hung CHEUNG, Wai Yee CHAN
  • Combinational use of mechanical manipulation and programin derivatives to increase Oct4, Sox2, or Nanog expression in fibroblasts
    Patent number: 10167451
    Abstract: The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: January 1, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Kenneth Ka Ho Lee, Tommy Lok Man Lo, Hoi Hung Cheung, Wai Yee Chan
  • COMBINATIONAL USE OF MECHANICAL MANIPULATION AND PROGRAMIN TO GENERATE PLURIPOTENT STEM CELLS FROM SOMATIC CELLS
    Publication number: 20160177271
    Abstract: The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).
    Type: Application
    Filed: December 22, 2014
    Publication date: June 23, 2016
    Inventors: Kenneth Ka Ho LEE, Tommy Lok Man LO, Hoi Hung CHEUNG, Wai Yee CHAN