Patents by Inventor Tomoaki Hirayama
Tomoaki Hirayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230398096Abstract: A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions] a pharmaceutically acceptable carrier, and a dissolution aid. is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.Type: ApplicationFiled: December 14, 2022Publication date: December 14, 2023Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Kentaro FURUMOTO, Koji SHIRAKI, Tomoaki HIRAYAMA
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Publication number: 20210052550Abstract: A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions] a pharmaceutically acceptable carrier, and a dissolution aid.is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.Type: ApplicationFiled: April 7, 2020Publication date: February 25, 2021Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Kentaro FURUMOTO, Koji SHIRAKI, Tomoaki HIRAYAMA
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Patent number: 10646468Abstract: A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions] a pharmaceutically acceptable carrier, and a dissolution aid.is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.Type: GrantFiled: May 11, 2016Date of Patent: May 12, 2020Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kentaro Furumoto, Koji Shiraki, Tomoaki Hirayama
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Patent number: 10398653Abstract: The present invention provides a method for producing a pharmaceutical composition which is a tablet and which contains tofogliflozin as an active ingredient. The method comprises mixing an additive and tofogliflozin to prepare a powder mixture and obtaining a tablet from the powder mixture by direct compression. The additive comprises at least one filler.Type: GrantFiled: January 29, 2019Date of Patent: September 3, 2019Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Kenta Wada, Tomoaki Hirayama, Kenichi Sakai, Shiho Yoshimura
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Publication number: 20190151248Abstract: The present invention provides a method for producing a pharmaceutical composition which is a tablet and which contains tofogliflozin as an active ingredient. The method comprises mixing an additive and tofogliflozin to prepare a powder mixture and obtaining a tablet from the powder mixture by direct compression. The additive comprises at least one filler.Type: ApplicationFiled: January 29, 2019Publication date: May 23, 2019Inventors: Kenta WADA, Tomoaki HIRAYAMA, Kenichi SAKAI, Shiho YOSHIMURA
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Patent number: 10231930Abstract: The present invention provides a method for producing a pharmaceutical composition which is a tablet and which contains tofogliflozin as an active ingredient. The method comprises mixing an additive and tofogliflozin to prepare a powder mixture and obtaining a tablet from the powder mixture by direct compression. The additive comprises at least one filler.Type: GrantFiled: December 26, 2014Date of Patent: March 19, 2019Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Kenta Wada, Tomoaki Hirayama, Kenichi Sakai, Shiho Yoshimura
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Publication number: 20160317494Abstract: A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions] a pharmaceutically acceptable carrier, and a dissolution aid.is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.Type: ApplicationFiled: May 11, 2016Publication date: November 3, 2016Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: KENTARO FURUMOTO, KOJI SHIRAKI, TOMOAKI HIRAYAMA
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Patent number: 9365514Abstract: A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions] a pharmaceutically acceptable carrier, and a dissolution aid is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.Type: GrantFiled: August 19, 2011Date of Patent: June 14, 2016Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kentaro Furumoto, Koji Shiraki, Tomoaki Hirayama
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Patent number: 9090133Abstract: The objective of the present invention is to provide a pneumatic tire that can desirably prevent generation of static electricity between the road face and the tire, while maintaining a low rolling resistance, so that the safety in use is further improved. In pneumatic tire of the present invention, each of tread rubber, breaker rubber and sidewall rubber that are respectively formed on a tread section, a breaker section and a sidewall section has a volume resistivity of 1×108 ?·cm or more, with a conductive layer having a volume resistivity smaller than 1×108 ?·cm and a thickness in a range from 0.2 to 2.0 mm being formed between a carcass ply forming the carcass and the sidewall rubber, and at least either conductive layer or a rubber cement layer that is formed so as to be made in contact with conductive layer and has a volume resistivity lower than that of the tread rubber is exposed to the surface of the tire.Type: GrantFiled: March 2, 2007Date of Patent: July 28, 2015Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Mamoru Uchida, Takao Wada, Tomoaki Hirayama
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Patent number: 9012499Abstract: The present invention provides a pharmaceutical composition comprising: one or more excipients selected from sugars and sugar alcohols in which equilibrium water content is 1% by weight or less at 25° C. and at 70% relative humidity; and oseltamivir phosphate, wherein an amount of each of glucose and mannose contained in the sugars and sugar alcohols as impurities is 0.01% by weight or less.Type: GrantFiled: February 20, 2007Date of Patent: April 21, 2015Assignees: Chugai Seiyaku Kabushiki Kaisha, F. Hoffman-la Roche AGInventors: Ryuji Kubota, Tomoaki Ohta, Tomoaki Hirayama, Hiroyuki Maeda, Christian Volland, Hans-Guenter Kaestle
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Patent number: 8921468Abstract: A rubber composition for a tire includes a rubber component containing at least one of a natural rubber and an epoxidized natural rubber, silica and a natural based wax, wherein the silica is contained in an amount of 10 parts by mass or more based on 100 parts by mass of the rubber component and the natural based wax is contained in an amount of 1.2% by mass or more and 2% by mass or less based on the total mass of the rubber composition for a tire, and to a tread, a side wall, a clinch and a tire using the rubber composition.Type: GrantFiled: March 14, 2008Date of Patent: December 30, 2014Assignee: Sumitomo Rubber Industries, Ltd.Inventors: Tomoaki Hirayama, Takao Wada, Noboru Wakabayashi, Keiji Ikeda
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Publication number: 20130143877Abstract: A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions] a pharmaceutically acceptable carrier, and a dissolution aid. is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.Type: ApplicationFiled: August 19, 2011Publication date: June 6, 2013Inventors: Kentaro Furumoto, Koji Shiraki, Tomoaki Hirayama
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Patent number: 8304480Abstract: A rubber composition for coating a steel cord, in which processability, durability and adhesive condition can be improved with favorable balance, and a tire using the rubber composition are provided. The rubber composition for coating a steel cord comprises 40 to 70 parts by weight of silica having a nitrogen adsorbing-specific surface area of 100 to 200 m2/g, 1 to 15 parts by weight of a silane coupling agent, 12 to 20 parts by weight of zinc oxide, 3.5 to 5 parts by weight of sulfur, and an organic cobalt in an amount of 0.05 to 0.3 part by weight, converted into metal cobalt amount, on the basis of 100 parts by weight of a rubber component, and a tire is prepared using the rubber composition.Type: GrantFiled: December 11, 2006Date of Patent: November 6, 2012Assignee: Sumitomo Rubber Industries, Ltd.Inventors: Mamoru Uchida, Takao Wada, Tomoaki Hirayama
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Patent number: 8261797Abstract: The present invention provides a rubber composition for coating a textile cord, and a tire using the rubber composition, wherein rolling resistance is lowered, and processability and rubber strength are excellent, as compared with a rubber composition for coating a textile cord comprising raw materials derived from petroleum resources as a main component, and a tire using the rubber composition, while considering environments and providing for the future decrease in petroleum resources supply. The rubber composition for coating a textile cord comprises 25 to 80 parts by mass of silica and 1 to 15 parts by mass of a silane coupling agent on the basis of 100 parts by mass of a diene rubber, wherein a nitrogen adsorbing-specific surface area of said silica is 70 to 150 m2/g.Type: GrantFiled: December 22, 2006Date of Patent: September 11, 2012Assignee: Sumitomo Rubber Industries, Ltd.Inventors: Tetsuya Kunisawa, Mamoru Uchida, Tomoaki Hirayama, Takao Wada
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Patent number: 8173738Abstract: The present invention provides a rubber composition for a tire which makes it possible to consider an effect on environment, prepare for decrease in supply quantity of petroleum in future and improve weather resistance and rubber strength in good balance, and a tire prepared by using the rubber composition. The rubber composition of the present invention comprises not less than 20 parts by weight of a silica, not more than 5 parts by weight of a carbon black and 2 to 20 parts by weight of a turpentine soot and/or lamp black having an average particle diameter of not more than 1,000 nm, based on 100 parts by weight of a rubber component comprising a natural rubber and/or an epoxidized natural rubber, and a tire prepared by using the rubber composition.Type: GrantFiled: September 21, 2011Date of Patent: May 8, 2012Assignee: Sumitomo Rubber Industries Ltd.Inventors: Tomoaki Hirayama, Takao Wada
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Publication number: 20120010348Abstract: The present invention provides a rubber composition for a tire which makes it possible to consider an effect on environment, prepare for decrease in supply quantity of petroleum in future and improve weather resistance and rubber strength in good balance, and a tire prepared by using the rubber composition. The rubber composition of the present invention comprises not less than 20 parts by weight of a silica, not more than 5 parts by weight of a carbon black and 2 to 20 parts by weight of a turpentine soot and/or lamp black having an average particle diameter of not more than 1,000 nm, based on 100 parts by weight of a rubber component comprising a natural rubber and/or an epoxidized natural rubber, and a tire prepared by using the rubber composition.Type: ApplicationFiled: September 21, 2011Publication date: January 12, 2012Applicant: Sumitomo Rubber Industries, Ltd.Inventors: Tomoaki HIRAYAMA, Takao WADA
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Patent number: 8044133Abstract: The present invention provides a rubber composition for a tire which makes it possible to consider an effect on environment, prepare for decrease in supply quantity of petroleum in future and improve weather resistance and rubber strength in good balance, and a tire prepared by using the rubber composition. The rubber composition of the present invention comprises not less than 20 parts by weight of a silica, not more than 5 parts by weight of a carbon black and 2 to 20 parts by weight of a turpentine soot and/or lamp black having an average particle diameter of not more than 1,000 nm, based on 100 parts by weight of a rubber component comprising a natural rubber and/or an epoxidized natural rubber, and a tire prepared by using the rubber composition.Type: GrantFiled: June 14, 2007Date of Patent: October 25, 2011Assignee: Sumitomo Rubber Industries, Ltd.Inventors: Tomoaki Hirayama, Takao Wada
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Patent number: 8044131Abstract: There is provided a rubber composition for a tread having excellent hardness and improving the processability and grip performance of a tire, and a tire comprising thereof. A rubber composition for a tread comprising 30 to 80 parts by weight of silica having a BET specific surface area of less than 150 m2/g and 10 parts by weight or less of carbon black based on 100 parts by weight of a rubber component comprising an epoxidized natural rubber, and a tire comprising thereof.Type: GrantFiled: January 5, 2006Date of Patent: October 25, 2011Assignee: Sumitomo Rubber Industries, Ltd.Inventors: Tomoaki Hirayama, Takao Wada, Mamoru Uchida
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Patent number: 7863371Abstract: A rubber composition for an inner liner improving rolling resistance performance of a tire and further improving processability is provided. A rubber composition for an inner liner comprising at least 30 parts by weight of silica having a BET specific surface area of less than 150 m2/g and at most 5 parts by weight or less of carbon black based on 100 parts by weight of a rubber component comprising a natural rubber and a tire having an inner liner comprising the same.Type: GrantFiled: March 2, 2006Date of Patent: January 4, 2011Assignee: Sumitomo Rubber Industries, Ltd.Inventors: Tomoaki Hirayama, Takao Wada, Mamoru Uchida
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Publication number: 20100252162Abstract: The present invention relates to a rubber composition for a sidewall, in which an effect on environments can be taken into consideration, provision for the future decrease of petroleum supply can be satisfied, and further, tear strength and flex crack growth resistance can be improved with favorable balance without increasing hardness, and a process for preparing the rubber composition. The rubber composition for a sidewall is characterized by comprising 15 to 60 parts by weight of silica and 2 to 20 parts by weight of a double bond-containing plasticizer on the basis of 100 parts by weight of a rubber component comprising 30 to 80% by weight of a natural rubber and 20 to 70% by weight of an epoxidized natural rubber.Type: ApplicationFiled: December 7, 2006Publication date: October 7, 2010Inventors: Takao Wada, Mamoru Uchida, Tomoaki Hirayama