Patents by Inventor Tomoaki Inoue

Tomoaki Inoue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11692173
    Abstract: The present invention provides, in order to prepare matured hepatocytes analogous in various points to primary hepatocytes, a method for preparing hepatocytes or cells that can be differentiated into hepatocytes from pluripotent stem cells, comprising the steps of: (1) culturing the pluripotent stem cells in a medium containing an activator of an activin receptor-like kinase-4,7; (2) culturing the cells obtained in the step (1) in a medium containing a bone morphogenetic factor and a fibroblast growth factor; (3) culturing the cells obtained in the step (2) in a medium containing an activator of a hepatocyte growth factor receptor and an activator of an oncostatin M receptor; and (4) culturing the cells obtained in the step (3) to obtain hepatocytes or cells that can be differentiated into hepatocytes, wherein in at least one of the steps (2), (3) and (4), cells are cultured on a high-density collagen gel membrane.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: July 4, 2023
    Assignees: TOKYO INSTITUTE OF TECHNOLOGY, KANTO KAGAKU KABUSHIKI KAISHA, CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Shoen Kume, Nobuaki Shiraki, Hiroyuki Yamaguchi, Tomoaki Inoue, Toshito Nakagawa, Jumpei Kiyokawa
  • Publication number: 20220167814
    Abstract: An autonomous cleaner includes: a main body including a housing, a drive wheel (wheel) attached to the housing, and a drive unit that drives the drive wheel; a map storage unit that stores map information for the main body to travel; a determination unit that determines a harmful concentrated region that is likely to generate a harmful substance including at least one of a virus and a bacterium; and a map information corrector that reflects and corrects, in the map information stored in the map storage unit, the harmful concentrated region determined by the determination unit.
    Type: Application
    Filed: August 16, 2021
    Publication date: June 2, 2022
    Inventors: Tomoaki INOUE, Koji ASAI, Yuko TSUSAKA
  • Publication number: 20220167808
    Abstract: An autonomous cleaner includes: a main body including a housing, a drive wheel (wheel) attached to the housing, and a drive unit that drives the drive wheel; a map storage unit that stores map information for the main body to travel; a determination unit that determines whether the main body approaches or comes into contact with a person infected with at least one of a virus and a bacterium; and a map information corrector that reflects, in the map information stored in the map storage unit, contact information on approach or contact of the main body with the infected person determined by the determination unit.
    Type: Application
    Filed: August 18, 2021
    Publication date: June 2, 2022
    Inventors: Tomoaki INOUE, Koji ASAI, Yuko TSUSAKA
  • Publication number: 20210325132
    Abstract: A shockwave supply device includes: a shockwave generating unit configured to generate a shockwave; a shockwave emitting unit configured to emit the shockwave; a conduit that is bendable and is provided at a part of a flow path of the shockwave from the shockwave generating unit to the shockwave emitting unit; a plurality of outer shell tubes provided outward in a radial direction of the conduit and provided along an axial direction of the conduit; and a coupling portion with which adjacent ones of the outer shell tubes are coupled to be rotatable with respect to each other about a vertical axis.
    Type: Application
    Filed: March 26, 2021
    Publication date: October 21, 2021
    Inventors: Keisuke MATSUYAMA, Kuninori TOGAI, Shin ASANO, Tomoaki INOUE, Tomohito NAKAMORI
  • Publication number: 20210207085
    Abstract: The present invention provides, in order to prepare matured hepatocytes analogous in various points to primary hepatocytes, a method for preparing hepatocytes or cells that can be differentiated into hepatocytes from pluripotent stem cells, comprising the steps of: (1) culturing the pluripotent stem cells in a medium containing an activator of an activin receptor-like kinase-4,7; (2) culturing the cells obtained in the step (1) in a medium containing a bone morphogenetic factor and a fibroblast growth factor; (3) culturing the cells obtained in the step (2) in a medium containing an activator of a hepatocyte growth factor receptor and an activator of an oncostatin M receptor; and (4) culturing the cells obtained in the step (3) to obtain hepatocytes or cells that can be differentiated into hepatocytes, wherein in at least one of the steps (2), (3) and (4), cells are cultured on a high-density collagen gel membrane.
    Type: Application
    Filed: October 9, 2018
    Publication date: July 8, 2021
    Applicants: TOKYO INSTITUTE OF TECHNOLOGY, KANTO KAGAKU KABUSHIKI KAISHA, CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Shoen KUME, Nobuaki SHIRAKI, Hiroyuki YAMAGUCHI, Tomoaki INOUE, Toshito NAKAGAWA, Jumpei KIYOKAWA
  • Patent number: 10718781
    Abstract: In one aspect, the present invention provides, for example, an improved method for identifying an epitope on a protein, comprising the following steps: (A) contacting a major histocompatibility complex (MHC molecule)-expressing cell differentiated from a stem cell or a progenitor cell derived therefrom with a target protein; (B) isolating a complex of a peptide contained in the target protein and the MHC molecule from the MHC molecule-expressing cell; and (C) eluting the peptide from the complex and identifying the peptide.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: July 21, 2020
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoaki Inoue, Shunsuke Ito, Nobuo Sekiguchi
  • Patent number: 10520386
    Abstract: This vibration measurement device is configured to measure the balancing vibration of the cartridge, a kind of rotating machines, who has a rotor and a cartridge body to support the rotor rotatably for variable operating speed, and is provided with a rigidly fixed support structure, acceleration sensors which detect the vibration of the cartridge, and a flat spring which elastically supports the cartridge with respect to the support structure and has a variable spring constant of elastic support.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: December 31, 2019
    Assignee: MITSUBISHI HEAVY INDUSTRIES ENGINE & TURBOCHARGER, LTD.
    Inventors: Tomoaki Inoue, Katsuya Yamashita, Rimpei Kawashita, Hiroshi Nakagawa, Nariaki Seike, Noriyuki Hayashi, Hideo Mori
  • Publication number: 20170219607
    Abstract: In one aspect, the present invention provides, for example, an improved method for identifying an epitope on a protein, comprising the following steps: (A) contacting a major histocompatibility complex (MHC molecule)-expressing cell differentiated from a stem cell or a progenitor cell derived therefrom with a target protein; (B) isolating a complex of a peptide contained in the target protein and the MHC molecule from the MHC molecule-expressing cell; and (C) eluting the peptide from the complex and identifying the peptide.
    Type: Application
    Filed: July 13, 2015
    Publication date: August 3, 2017
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoaki INOUE, Shunsuke ITO, Nobuo SEKIGUCHI
  • Publication number: 20170176881
    Abstract: A liquid developer for electrophotography or electrostatic recording is obtained by dispersing, in an insulating solvent, colored resin particles obtained according to the coacervation method from at least a pigment, pigment dispersion agent and binder resin, wherein the insulating solvent has been mixed in such a way that aliphatic hydrocarbon solvent having 11 to 12 carbon atoms accounts for 8.0 to 20.0 percent by mass, and aliphatic hydrocarbon solvent having 17 to 30 carbon atoms accounts for 2.0 to 45.0 percent by mass, and a total of these aliphatic hydrocarbon solvents having 11 to 30 carbon atoms accounts for 99 percent by mass or more, relative to the total mass of insulating solvent, and also in such a way that the viscosity of the insulating solvent at 25° C. becomes 2.0 to 10.0 mPa·s.
    Type: Application
    Filed: February 4, 2015
    Publication date: June 22, 2017
    Inventors: Katsutoshi OKAMOTO, Hirohito MAEDA, Tomoaki INOUE, Yuya WATANABE
  • Publication number: 20170168410
    Abstract: An object of the present invention is to provide a liquid developer for electrophotography or electrostatic recording, demonstrating good particle uniformity, preservation stability, fixing property, and electrophoretic migration property. To achieve the aforementioned object, the present invention provides a liquid developer that contains colored resin particles granulated by utilizing the coacervation method, from at least an acid carbon black as pigment, binder resin containing acid group-containing resin, basic group-containing pigment dispersion agent, pigment dispersion aid which is an acid pigment derivative and accounts for 0.1 to 10.0 parts by mass per 100 parts by mass of the pigment, and granulating aid, wherein the colored resin particles are dispersed in an insulating solvent by means of a particle dispersion agent.
    Type: Application
    Filed: February 4, 2015
    Publication date: June 15, 2017
    Inventors: Katsutoshi OKAMOTO, Hirohito MAEDA, Tomoaki INOUE, Jun KAWABATA
  • Publication number: 20170138811
    Abstract: This vibration measurement device is configured to measure the balancing vibration of the cartridge, a kind of rotating machines, who has a rotor and a cartridge body to support the rotor rotatably for variable operating speed, and is provided with a rigidly fixed support structure, acceleration sensors which detect the vibration of the cartridge, and a flat spring which elastically supports the cartridge with respect to the support structure and has a variable spring constant of elastic support.
    Type: Application
    Filed: June 27, 2014
    Publication date: May 18, 2017
    Applicant: MITSUBISHI HEAVY INDUSTRIES ENGINE & TURBOCHARGER, LTD.
    Inventors: Tomoaki INOUE, Katsuya YAMASHITA, Rimpei KAWASHITA, Hiroshi NAKAGAWA, Nariaki SEIKE, Noriyuki HAYASHI, Hideo MORI
  • Publication number: 20170010555
    Abstract: A liquid developer for electrophotography or electrostatic recording includes colored resin particles, which are constituted by at least a pigment, a binder resin containing acid group-containing resin, a basic group-containing pigment dispersion agent, and a granulating aid, with the colored resin particles formed in an insulating solvent by utilizing the coacervation method. A carbodiimide compound having at least one carbodiimide group is used as the granulating aid, with the ratio of the number of active hydrogens in the acid group-containing resin to the number of carbodiimide groups in the carbodiimide compound adjusted to 1:0.01 or more but less than 1:1.00, and the colored resin particles are dispersed in the insulating solvent by a particle dispersion agent. The liquid developer has good uniformity, preservation stability, fixing property, and electrophoretic migration property of particles.
    Type: Application
    Filed: February 4, 2015
    Publication date: January 12, 2017
    Inventors: Koji IWASE, Katsutoshi OKAMOTO, Hideo SHIBATA, Hirohito MAEDA, Tomoaki INOUE
  • Patent number: 9169866
    Abstract: A tilting pad bearing is provided that can reduce an amount of oil leaking from the side edges of a sliding surface of a pad, thereby reducing an amount of oil to be fed onto the sliding surface of the pad. The tilting pad bearing includes journal pads arranged in a circumferential direction of a rotating shaft, and a bearing housing for carrying the journal pads in a tiltable manner via associated pivots. Lubricating oil is fed to a sliding surface of the journal pad via an oil-feeding hole formed in the journal pad. The sliding surface of the journal pad has a portion formed so that the portion has an axial width that gradually increases, as the axial width approaches the circumferential downstream side of the rotating shaft, from an oil-feed start position.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: October 27, 2015
    Assignee: Mitsubishi Hitachi Power Systems, Ltd.
    Inventors: Motoki Sato, Kenta Suzuki, Makoto Hemmi, Tomoaki Inoue, Kenichi Murata
  • Publication number: 20150003762
    Abstract: A tilting pad bearing is provided that can reduce an amount of oil leaking from the side edges of a sliding surface of a pad, thereby reducing an amount of oil to be fed onto the sliding surface of the pad. The tilting pad bearing includes journal pads 2 arranged in a circumferential direction of a rotating shaft 1; and a bearing housing 4 for carrying the journal pads 2 in a tiltable manner via associated pivots 3. Lubricating oil is fed to a sliding surface 14 of the journal pad 2 via an oil-feeding hole 5 formed in the journal pad 2. The sliding surface 14 of the journal pad 2 has a portion formed so that the portion has an axial width that gradually increases, as the axial width approaches the circumferential downstream side of the rotating shaft, from an oil-feed start position.
    Type: Application
    Filed: June 25, 2014
    Publication date: January 1, 2015
    Inventors: Motoki SATO, Kenta SUZUKI, Makoto HEMMI, Tomoaki INOUE, Kenichi MURATA
  • Patent number: 8790012
    Abstract: In a journal bearing device having an upper bearing liner, a lower bearing liner, an upper base metal and a lower base metal, the lower bearing liner is divided into a sliding portion having a sliding surface and a clearance portion provided with a space between the lower bearing liner and a rotor, and is provided with an oil path formed on a back side of the sliding portion and extending from a border portion between the sliding portion and the clearance portion toward an upstream side in the rotational direction of the rotor, and an oil supply hole extending from an upstream end portion of the oil path to the sliding surface, and the lower base metal has an oil supply path and extending from an outer circumferential side of the lower base metal to the oil path at the border portion.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: July 29, 2014
    Assignee: Hitachi, Ltd.
    Inventors: Kenta Suzuki, Makoto Hemmi, Tomoaki Inoue, Kenichi Murata
  • Publication number: 20140197260
    Abstract: In a vertical mill, a mill table is supported in a housing by a support shaft center, which is along a vertical direction, in such a manner as to be driven and rotated, and above the mill table, a mill roller is rotatably supported by a first support shaft, and the mill roller is capable of rotating the mill table in such a manner that an external peripheral surface of the mill roller comes into contact with an upper surface of the mill table, and a support arm configured to support the first support shaft is swingably supported on the housing by a second support shaft, in such a manner that the mill roller can come close to or move away from the mill table, and a reaction force load giving device is provided that has a dumper filled with a magnetorheological fluid and magnetizes the magnetorheological fluid.
    Type: Application
    Filed: September 6, 2012
    Publication date: July 17, 2014
    Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Kensuke Futahashi, Hiroyuki Kanazawa, Shin Asano, Tomoaki Inoue
  • Publication number: 20140169712
    Abstract: In a journal-bearing device for bearing a rotary shaft of a rotary machine, including an upper-bearing liner, a lower-bearing liner connected to a lower part of the upper-bearing liner, and an oil removing groove provided in a sliding surface of the lower-bearing liner and extending to both bearing side surfaces from a center portion in a bearing-width direction, the oil removing groove is provided on a downstream side in a rotary shaft-rotation-direction relative to an oil-film-pressure producing portion of the sliding surface of the lower-bearing liner, an end portion of the oil removing groove in the bearing-width direction is arranged on the rotation direction downstream side relative to a center portion of the groove in the bearing-width direction, and the journal-bearing device has a sliding surface on a downstream side of the oil removing groove of the lower-bearing liner in the rotary-shaft rotation direction.
    Type: Application
    Filed: November 14, 2013
    Publication date: June 19, 2014
    Applicant: Hitachi, Ltd.
    Inventors: Kenta SUZUKI, Makoto HEMMI, Tomoaki INOUE, Kenichi MURATA
  • Patent number: 8729887
    Abstract: A rotation angle sensor comprises: a resolver stator including an excitation coil for receiving an excitation signal and a detection coil (a sine wave coil and a cosine wave coil) for outputting a detection signal; and a resolver rotor rotatably placed to face the stator. The resolver stator is formed on a stator flat plate. The resolver rotor is made of a flat-shaped rotor flat plate. The stator flat plate and the rotor flat plate are placed in parallel to face each other. The rotor flat plate is formed with a cutout.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: May 20, 2014
    Assignee: Aisan Kogyo Kabushiki Kaisha
    Inventors: Shinya Suzuki, Takehide Nakamura, Tomoaki Inoue, Ryojiro Kanemitsu
  • Patent number: 8459932
    Abstract: A bearing device of a gas turbine power generation equipment provides damping vibration of a shaft and lubricates and cools the bearing main body. The bearing devices have sleeves provided on the outer circumference sides of the bearing main bodies and bearing housings holding the respective sleeves via O-rings while each forming an annular clearance passage between each of the outer circumferences of the sleeves and a corresponding one of the bearing housings. The bearing housing has a feed-water hole communicating with the clearance passage and adapted to feed water thereto. The sleeve has a lead water hole communicating with the clearance passage and is adapted to lead water to the bearing main body, and a discharge hole which communicates with the clearance passage and is adapted to discharge water therefrom.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: June 11, 2013
    Assignee: Hitachi, Ltd.
    Inventors: Susumu Nakano, Tomoaki Inoue, Tadaharu Kishibe, Hiroyuki Shiraiwa
  • Patent number: 8450893
    Abstract: A casing of a motor with resolver includes a stator, a motor shaft rotatably supported by a bearing, a motor rotor integrally rotatable with the motor shaft, and a resolver for detecting a rotation angle of the motor rotor. The resolver includes a disc-shaped resolver stator held on the motor casing and having a surface on which a thin-film-shaped coil is formed, and a disc-shaped resolver rotor provided on an end face of the motor rotor and having a surface on which a thin-film-shaped coil is formed. Part of the motor casing holding the outer periphery of the resolver stator is formed as a shield portion cylindrically protruding along the outer periphery of the resolver rotor to the rotor. The motor casing and the shield portion are each made of a non-magnetic conductive material.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: May 28, 2013
    Assignee: Aisan Kogyo Kabushiki Kaisha
    Inventors: Hiroaki Miyazaki, Takehide Nakamura, Tomoaki Inoue, Takahiro Nakamura