Abstract: The present invention provides a grease composition which makes it possible to prevent deterioration in sealing properties even when base oil having a kinetic viscosity of as low as, for example, 5-40 mm2/s is used and which makes it possible to realize both sealing properties and a decrease in torque. The present invention also provides a rolling device. A sealing member (12a) comprises a plurality of sealing lips (114), (115), (116) each of which is made of an elastic material. A grease composition is sealed in void parts (121), (122) that are each located between a sliding surface of a slinger (106), on which the plurality of sealing lips slide, and two adjacent sealing lips. This grease composition contains base oil and a polar polymer. The polar polymer has a weight-average molecular weight of 5,000-140,000.

Abstract: Provided is a rolling bearing using a retainer, particularly a highly reliable retainer in which dimensional stability required for a retainer of an outer ring guide type, ductility required for a crown-type retainer, improvement in adhesion of grease with a poly-?-olefin oil or the like as a base oil, and deformation prevention at a high speed can be achieved. The rolling bearing includes at least an inner ring 1, an outer ring 3, a synthetic resin retainer 9, and a rolling element 7, in which the synthetic resin retainer 9 is formed of a polyamide resin composition including polyamide 410 and a reinforcing fiber material with a content of 0% by weight to 40% by weight.

Abstract: The rolling device of the present invention is a rolling device that is equipped with an inner ring, an outer ring, and a plurality of rolling elements disposed between the inner ring and the outer ring so as to freely roll, and that is packed with a lubricant composition containing a gelling agent in which a difference between a worked consistency and an unworked consistency is 40-130, and this rolling device has low-torque characteristics, is excellent in terms of recovery property and heat resistance, is free from lubricant leakage, and has a long life.

Abstract: A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same. The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.

Abstract: A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same. The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.

Abstract: An object of the invention is to provide a grease composition capable of keeping a good lubrication condition for a long period of time even when water has mixed therein, thereby inhibiting white structure flaking and corrosion. Another object is to provide a vehicular hub unit bearing which hardly suffers from white structure flaking and corrosion even when used in an environment where water may penetrate into it and which therefore has a long life. The invention provides a rolling bearing with, sealed up therein, a grease composition containing a waterproof film-forming additive added thereto; a grease composition for hub unit bearings, containing a base oil that comprises at least one of mineral oil and synthetic oil as the main ingredient thereof, and a thickener and a flaking inhibitor; and a vehicular hub unit bearing with the grease composition sealed up therein.

Abstract: The waterproof grease composition of the present application comprises a base oil that comprises at least one of mineral oil and synthetic oil and having a kinematic viscosity of from 10 to 400 mm2/sec at 40° C., a thickener, and a waterproofness-imparting agent selected from surfactant, metal soap, fluorine-containing water repellent, silicone-type water repellent, pH-controlling agent, wax, polymer and graphite. Accordingly, it may prevent peeling such as white structure peeling even when water is mixed therein.

Abstract: A protein having amino acid sequence in SEQ ID NO: 1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID NO: 1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same. The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.

Abstract: A protein consisting of the amino acid sequence in SEQ ID No: 1 derived from human MP52 and a homodimer protein thereof useful for treating cartilage and/or bone diseases and a process for its preparation.

Abstract: A protein having amino acid sequence in SEQ ID No.: 1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.: 1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same.

Abstract: A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same.

Abstract: The present invention provides synthetic peptide derivatives represented by the formulaP.sup.1 -R.sup.1 -P.sup.2wherein P.sup.1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P.sup.2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R.sup.1 denotes a linker with a property that does not interfere with the activity of the each peptide P.sup.1 and P.sup.2 to bind N-terminal end of the peptides P.sup.1 and P.sup.2.The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier.The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.

Abstract: A variable output vane pump for use with an automotive automatic transmission. At least one pressure chamber is formed between the circular bore of a housing and the outer circumference of a ring by means of at least one seal pin which is fitted in the axial groove formed in the ring circumference and which is opened in the housing bore. The ring is urged by the action of a spring, which is fitted in the housing, in a direction opposite to the pressure to be built up by the pressure chamber. An elastic member is fitted in the bottom of the axial groove to urge the seal pin both toward the housing bore and at the same time toward one of the side walls of the axial groove. The urging direction of the elastic member and a tangential line, on which the seal pin is tangential to the housing bore, are angularly positioned at an acute angle with respect to each other.