Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.

Abstract: Provided herein are anti-EGFRvII antibodies and binding fragments thereof. The anti-EGFRvIII antibodies of the disclosure are useful for the treatment of cancers through, e.g., antibody-dependent cell cytotoxicity (ADCC). Also provided herein are methods of making and using the anti-EGFRvIII antibodies for the treatment of cancer, and polynucleotides that encode the same.

Abstract: Provided herein are PD-1 agonist antibodies which bind PD-1. The PD-1 agonist antibodies of the disclosure are useful for the treatment of autoimmune and inflammatory diseases through the promotion of PD-1 signaling. Also provided herein are methods of use for the PD-1 agonist antibodies.

Abstract: An object of the present invention is to provide an air conditioner for a rail vehicle that is excellent in cleanliness and comfort by cleaning the air conditioner at an appropriate timing without causing discomfort to passengers. An air conditioner for a rail vehicle including a vehicle control system includes: a refrigeration cycle device 3 that can execute a cleaning operation; and an air conditioning control device 4 that controls the refrigeration cycle device, and the air conditioning control device 4 can communicate with the vehicle control system 2 and causes the refrigeration cycle device 3 to execute a cleaning operation on the basis of status information obtained from the vehicle control system 2.

Abstract: Provided is an air conditioning system for a railway vehicle that is of a roof installation type. The air conditioning system includes a heat exchanger through which at least air inside the railway vehicle passes, and an ultraviolet-ray irradiation device. The heat exchanger and the ultraviolet-ray irradiation device are arranged between an upper cover curved in an upwardly protruding shape and a bottom plate. The heat exchanger has an air suction surface arranged so as to be irradiated with ultraviolet rays generated by the ultraviolet-ray irradiation device. A member that does not transmit the ultraviolet rays is arranged on a straight line interconnecting the ultraviolet-ray irradiation device and an interior space of the railway vehicle.

Abstract: A method of recovering lactide which includes throwing a polylactic acid and a depolymerization catalyst into an extruder (1) communicated with a vent chamber (3) maintained under a reduced pressure, melt-kneading the polylactic acid and the depolymerization catalyst together in the extruder (1), feeding the melt-kneaded product thereof into the vent chamber (3), depolymerizing the polylactic acid in the vent chamber (3), gasifying the formed lactide and recovering the gasified lactide from the vent chamber (3).

Abstract: A method of recovering lactide which includes introducing a molten resin composition that contains a polylactic acid, a depolymerization catalyst and a carrier resin into a vent chamber (3) that is maintained under a reduced pressure using a first screw conveyer passage (11) that extends in the vent chamber (3), gasifying the lactide contained in the molten resin composition, and recovering a gaseous lactide from the vent chamber, wherein a second screw conveyer passage (60) is provided under the first screw conveyer passage (11) in the vent chamber (3) to recover the carrier resin.

Abstract: A method of recovering lactide which includes throwing a polylactic acid and a depolymerization catalyst into an extruder (1) communicated with a vent chamber (3) maintained under a reduced pressure, melt-kneading the polylactic acid and the depolymerization catalyst together in the extruder (1), feeding the melt-kneaded product thereof into the vent chamber (3), depolymerizing the polylactic acid in the vent chamber (3), gasifying the formed lactide and recovering the gasified lactide from the vent chamber (3).

Abstract: A method of recovering lactide which includes introducing a molten resin composition that contains a polylactic acid, a depolymerization catalyst and a carrier resin into a vent chamber (3) that is maintained under a reduced pressure using a first screw conveyer passage (11) that extends in the vent chamber (3), gasifying the lactide contained in the molten resin composition, and recovering a gaseous lactide from the vent chamber, wherein a second screw conveyer passage (60) is provided under the first screw conveyer passage (11) in the vent chamber (3) to recover the carrier resin.

Abstract: A suture technique evaluation apparatus evaluates a suture technique performed on a simulated body simulating a part of the human body, and the suture technique evaluation apparatus includes a camera configured to image at least a suture region where suturing is performed on the simulated body, and a ligation force evaluation part adapted to evaluate the ligation force of the suturing on the basis of image data taken by the camera.

Abstract: A suture technique evaluation apparatus evaluates a suture technique performed on a simulated body simulating a part of the human body, and the suture technique evaluation apparatus includes a camera configured to image at least a suture region where suturing is performed on the simulated body, and a ligation force evaluation part adapted to evaluate the ligation force of the suturing on the basis of image data taken by the camera.