Patents by Inventor Tomofumi Kageyama

Tomofumi Kageyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing corneal endothelial cell
    Patent number: 9347041
    Abstract: The present invention relates to a method for preparing corneal endothelial progenitor cells by adherent culturing a cell population isolated from corneal endothelial cell tissue at a low density by using a serum-free medium. The present invention also relates to a method for preparing corneal endothelial cells by differentiation-inducing the corneal endothelial progenitor cells obtained by the aforementioned method. According to the present invention, corneal endothelial progenitor cells can be selectively grown from a corneal tissue-derived cell population, and corneal endothelial cells obtained by inducing the corneal endothelial progenitor cells can be applied to treatment of corneal endothelial diseases. As a result, problems of corneal transplantation such as shortage of donors and occurrence of rejection can be solved.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: May 24, 2016
    Assignee: OSAKA UNIVERSITY
    Inventors: Ryuhei Hayashi, Susumu Hara, Tomofumi Kageyama, Kohji Nishida
  • METHOD FOR PREPARING CORNEAL ENDOTHELIAL CELL
    Publication number: 20140170751
    Abstract: The present invention relates to a method for preparing corneal endothelial progenitor cells by adherent culturing a cell population isolated from corneal endothelial cell tissue at a low density by using a serum-free medium. The present invention also relates to a method for preparing corneal endothelial cells by differentiation-inducing the corneal endothelial progenitor cells obtained by the aforementioned method. According to the present invention, corneal endothelial progenitor cells can be selectively grown from a corneal tissue-derived cell population, and corneal endothelial cells obtained by inducing the corneal endothelial progenitor cells can be applied to treatment of corneal endothelial diseases. As a result, problems of corneal transplantation such as shortage of donors and occurrence of rejection can be solved.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 19, 2014
    Applicant: OSAKA UNIVERSITY
    Inventors: Ryuhei Hayashi, Susumu Hara, Tomofumi Kageyama, Kohji Nishida
  • METHOD FOR INDUCING DIFFERENTIATION INTO EPITHELIAL PROGENITOR CELL/STEM CELL POPULATION AND CORNEAL EPITHELIAL CELL POPULATION FROM INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20120142103
    Abstract: The present invention relates to: a method for inducing differentiation into an epithelial progenitor cell/stem cell population or a corneal epithelial cell population by culturing, under particular conditions, induced pluripotent stem cells induced from mammalian somatic cells or undifferentiated stem cells; an epithelial progenitor cell/stem cell population or a corneal epithelial cell population obtained by the method; and a cell preparation for the treatment of epithelial disease and a cell sheet, which are prepared using these cell populations.
    Type: Application
    Filed: May 18, 2010
    Publication date: June 7, 2012
    Inventors: Kohji Nishida, Ryuhei Hayashi, Miharu Sakurai, Tomofumi Kageyama, Shinya Yamanaka, Keisuke Okita