Patents by Inventor Tomofumi NAKADA

Tomofumi NAKADA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving thermal stability of antibody and method for producing modified antibody
    Patent number: 11884741
    Abstract: Disclosed is a method for producing a modified antibody, comprising: in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue; and recovering the modified antibody.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: January 30, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Tomofumi Nakada, Nobuyuki Ide
  • METHOD FOR IMPROVING AFFINITY OF ANTIBODY FOR ANTIGEN AND USE THEREOF
    Publication number: 20220204649
    Abstract: Disclosed is a method for improving affinity of an antibody for an antigen, the method comprising: in the antibody, changing at least 3 amino acid residues of framework region 3 (FR3) as defined by Kabat method to arginine residues or lysine residues, thereby improving affinity of an antibody for an antigen as compared with that of an antibody before said at least 3 amino acid residues are changed to arginine residues or lysine residues, wherein said at least 3 amino acid residues comprise at least 3 selected from the group consisting of amino acid residues at positions 68, 70, 72, 74, 75, 77, 79, 81, 82A, 82B, 83, 84, 85 and 87 of a heavy chain as defined by the Kabat method.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 30, 2022
    Applicant: SYSMEX CORPORATION
    Inventors: Tomofumi NAKADA, Yuriko Egashira, Atsushi Fukunaga
  • METHOD FOR IMPROVING THERMAL STABILITY OF ANTIBODY AND METHOD FOR PRODUCING MODIFIED ANTIBODY
    Publication number: 20210347910
    Abstract: Disclosed is a method for producing a modified antibody, comprising: in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue; and recovering the modified antibody.
    Type: Application
    Filed: February 22, 2021
    Publication date: November 11, 2021
    Applicant: SYSMEX CORPORATION
    Inventors: Tomofumi NAKADA, Nobuyuki IDE
  • Method for producing antibody
    Patent number: 10995133
    Abstract: Disclosed is an antibody in which the 80th amino acid residue in a variable region based on the Kabat method and the 171th amino acid residue in a constant region based on the Kabat method are substituted with cysteine in an antibody in which the 80th amino acid residue in the variable region and the 171th amino acid residue in the constant region are not cysteine.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: May 4, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Nobuyuki Ide, Tomofumi Nakada
  • METHOD FOR PRODUCING ANTIBODY
    Publication number: 20190040119
    Abstract: Disclosed is an antibody in which the 80th amino acid residue in a variable region based on the Kabat method and the 171th amino acid residue in a constant region based on the Kabat method are substituted with cysteine in an antibody in which the 80th amino acid residue in the variable region and the 171th amino acid residue in the constant region are not cysteine.
    Type: Application
    Filed: August 2, 2018
    Publication date: February 7, 2019
    Applicant: SYSMEX CORPORATION
    Inventors: Nobuyuki IDE, Tomofumi NAKADA