Patents by Inventor Tomoharu Motoyama

Tomoharu Motoyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-O-sulfation enzyme mutant and 3-O-sulfation enzyme mutant, and method for using same
    Patent number: 11851688
    Abstract: The present invention provides a 2-OST mutant exhibiting a high activity.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: December 26, 2023
    Assignee: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Tomoko Shimizu, Uno Tagami, Yasuhiro Mihara, Masayuki Sugiki, Shogo Nakano, Tomoharu Motoyama, Sohei Ito
  • Method for producing heparosan compound having isomerized hexuronic acid residue
    Patent number: 11639513
    Abstract: The present invention provides a method for producing a heparosan compound having an isomerized hexuronic acid residue and a method for producing a heparan sulfate with improved C5-epimerization efficiency.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: May 2, 2023
    Assignee: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Yasuhiro Mihara, Shogo Nakano, Tomoharu Motoyama, Souhei Ito
  • 2-O-Sulfation Enzyme Mutant and 3-O-Sulfation Enzyme Mutant, and Method for Using Same
    Publication number: 20230105158
    Abstract: The present invention provides a 2-OST mutant exhibiting a high activity.
    Type: Application
    Filed: November 18, 2022
    Publication date: April 6, 2023
    Applicant: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Tomoko Shimizu, Uno Tagami, Yasuhiro Mihara, Masayuki Sugiki, Shogo Nakano, Tomoharu Motoyama, Sohei Ito
  • Ligase mutant
    Patent number: 11525132
    Abstract: Ligase mutants of the following (1), (2), or (3): (1) a ligase mutant comprising an amino acid sequence showing 95% or more identity to the amino acid sequence of SEQ ID NO: 1, and having a nucleic acid-linking activity; (2) a ligase mutant comprising an amino acid sequence showing 90% or more identity to the amino acid sequence of SEQ ID NO: 2, and having a nucleic acid-linking activity; or (3) a ligase mutant comprising an amino acid sequence showing 97% or more identity to the amino acid sequence of SEQ ID NO: 3, and having a nucleic acid-linking activity, have excellent properties.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: December 13, 2022
    Assignee: AJINOMOTO CO., INC.
    Inventors: Miwa Konishi, Shohei Kajimoto, Yusuke Hagiwara, Yasuhiro Mihara, Shogo Nakano, Tomoharu Motoyama, Sohei Ito
  • LIGASE MUTANT
    Publication number: 20210301280
    Abstract: Ligase mutants of the following (1), (2), or (3): (1) a ligase mutant comprising an amino acid sequence showing 95% or more identity to the amino acid sequence of SEQ ID NO: 1, and having a nucleic acid-linking activity; (2) a ligase mutant comprising an amino acid sequence showing 90% or more identity to the amino acid sequence of SEQ ID NO: 2, and having a nucleic acid-linking activity; or (3) a ligase mutant comprising an amino acid sequence showing 97% or more identity to the amino acid sequence of SEQ ID NO: 3, and having a nucleic acid-linking activity, have excellent properties.
    Type: Application
    Filed: March 23, 2021
    Publication date: September 30, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Miwa KONISHI, Shohei KAJIMOTO, Yusuke HAGIWARA, Yasuhiro MIHARA, Shogo NAKANO, Tomoharu MOTOYAMA, Sohei ITO
  • 2-O-Sulfation Enzyme Mutant and 3-O-Sulfation Enzyme Mutant, and Method for Using Same
    Publication number: 20200181588
    Abstract: The present invention provides a 2-OST mutant exhibiting a high activity.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 11, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Tomoko Shimizu, Uno Tagami, Yasuhiro Mihara, Masayuki Sugiki, Shogo Nakano, Tomoharu Motoyama, Sohei Ito
  • Method for Producing Heparosan Compound Having Isomerized Hexuronic Acid Residue
    Publication number: 20190338330
    Abstract: The present invention provides a method for producing a heparosan compound having an isomerized hexuronic acid residue and a method for producing a heparan sulfate with improved C5-epimerization efficiency.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 7, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Yasuhiro Mihara, Shogo Nakano, Tomoharu Motoyama, Souhei Ito