Abstract: The present invention provides an immunological detection method for trimeric type I collagen N-terminal propeptide in a biological sample, which uses a first antibody that binds to a specific portion of a pro-?1 chain in the trimeric type I collagen N-terminal propeptide and a second antibody that binds to a specific portion of a pro-?2 chain in the trimeric type I collagen N-terminal propeptide. The immunological detection method is easy to handle and can specifically (selectively) measure the trimer in biological samples containing the trimer and monomer of the ?-chain of PINP.

Abstract: There is provided an automated analysis device capable of transferring instruments to be used for an analysis process to a predetermined processing position efficiently and rapidly. In an automated analysis device of the invention, a transfer unit forming a transfer mechanism to transfer instruments to be used for analyte processing into an analyte processing space includes a holding portion to hold the instruments. The holding portion includes a first fitting attachment portion to be attachable to a first instrument in a fitted state, and a second fitting attachment portion to be attachable to a second instrument in a fitted state.

Abstract: A problem to be solved is to improve the specificity of an anti-AIM antibody for free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for measuring an amount of free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an anti-AIM antibody in the presence of an anti-IgM antibody.

Abstract: It is an object of the present invention to provide a method for suppressing non-specific reactions using a highly versatile method without affecting specific reactions. The present invention provides a detection method for detecting a target antigen in a sample using a specific antibody that specifically binds to the antigen, the method comprising: a) a step of bringing the sample into contact with a modified antibody; and b) a step of bringing the sample into contact with the specific antibody simultaneously with or after the step a), which is a highly versatile method that can suppress non-specific reactions.

Abstract: A measurement reagent for a cross-linked N-telopeptide of type I collagen containing uric acid or its salt. This reagent is easier to handle and enables NTx measurement with higher accuracy.

Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2 in a biological sample, including using two types of monoclonal antibodies or antibody fragments thereof that bind to a peptide fragment having 30 or less consecutive amino acids in a nucleocapsid protein of SARS-CoV-2, wherein the two types of monoclonal antibodies or antibody fragments thereof recognize different epitopes

Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2, including a step of contacting a biological sample with a monoclonal antibody or an antibody fragment thereof that binds to a nucleocapsid protein of SARS-COV-2, wherein the monoclonal antibody or the antibody fragment thereof binds to the SARS-CoV-2 treated with a serine protease.

Abstract: The problem addressed by the present invention is to provide an immunological assay method using a monoclonal antibody and a kit including the monoclonal antibody, which can be used for assaying ICTP without requiring special facilities. This problem can be solved by a method for immunological assay of type I collagen C-terminal telopeptide in a biological sample, including contacting type I collagen C-terminal telopeptide with a monoclonal antibody that recognizes an amino acid sequence represented by GFDFSFLP (SEQ ID NO: 1) as an epitope.

Abstract: A problem to be solved by the invention is to improve the sensitivity of measurement of an analyte in a sample by a sandwich immunoassay. The sensitivity can be improved significantly in a sandwich immunoassay using a first antibody and a second antibody when one or both of the first antibody and the second antibody are a mixture of a monoclonal antibody recognizing a linear epitope and a monoclonal antibody recognizing a conformational epitope.

Abstract: A problem to be solved is to detect only free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for free AIM in a biological sample using an anti-AIM monoclonal antibody having a property of reacting with free AIM and not reacting with complex AIM, wherein the anti-AIM monoclonal antibody is an antibody binding to an epitope in the SRCR2 domain of human AIM.

Abstract: A problem to be solved is to further improve the specificity for free AIM of an antibody specifically reacting with free AIM and to diagnose NASH without imposing a burden on patients and medical staffs. The problem can be solved by an immunoassay method for free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an antibody specifically reacting with free AIM in a presence of an anti-IgM antibody.

Abstract: There is provided an automated analysis device capable of transferring a reagent for reagent dispensing efficiently and rapidly. An automated analysis device of the invention includes a reagent transfer unit to transfer a reagent suction nozzle between a reaction unit and a reagent supply unit. In a region of an analyte processing space where a tip supply unit, the reagent supply unit, a tip disposal unit, and the reaction unit are lined up along a straight line, the reagent transfer unit forms a uniaxial transfer line where the reagent suction nozzle is moved only in a uniaxial direction along the straight line for a reagent transfer.

Abstract: There is provided an automated analysis device capable of transferring instruments to be used for an analysis process to a predetermined processing position efficiently and rapidly. In an automated analysis device of the invention, a transfer unit forming a transfer mechanism to transfer instruments to be used for analyte processing into an analyte processing space includes a holding portion to hold the instruments. The holding portion includes a first fitting attachment portion to be attachable to a first instrument in a fitted state, and a second fitting attachment portion to be attachable to a second instrument in a fitted state.

Abstract: There is provided an automated analysis device capable of transferring a rack to a predetermined instrument extraction position efficiently and rapidly, the rack being loaded with instruments to be used for an analysis process. An automated analysis device of the invention includes a conveyance unit to raise and lower a plurality of racks in a vertically stacked state to convey the racks into an analyte processing space, the racks being loaded with instruments to be used for analyte processing. The conveyance unit includes a movement mechanism to move an uppermost rack from a rack standby position to an extraction position with guidance of a protrusion and a recess while maintaining a state of slidable protrusion and recess engagement between the uppermost rack and a rack below the uppermost rack.

Abstract: A problem to be solved is to improve the specificity of an anti-AIM antibody for free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for measuring an amount of free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an anti-AIM antibody in the presence of an anti-IgM antibody.

Abstract: A method and a diagnostic agent kit for detecting viral liver cancer having excellent sensitivity and specificity are provided. The problem can be solved by a method for detecting viral liver cancer, comprising measuring an amount of free AIM in a biological sample from a subject and comparing the measured amount of free AIM with a reference value.

Abstract: The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing thrombin and/or an antibody reacting with human fibrin-like related substances to the reagents. The immunoassay of the invention comprises the steps of adding thrombin and/or an antibody reacting with human fibrin-like related substances to the reagents, and measuring PIVKA-II in serum or plasma.