Patents by Inventor Tomohide Asai
Tomohide Asai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250130242Abstract: The present invention provides an immunological detection method for trimeric type I collagen N-terminal propeptide in a biological sample, which uses a first antibody that binds to a specific portion of a pro-?1 chain in the trimeric type I collagen N-terminal propeptide and a second antibody that binds to a specific portion of a pro-?2 chain in the trimeric type I collagen N-terminal propeptide. The immunological detection method is easy to handle and can specifically (selectively) measure the trimer in biological samples containing the trimer and monomer of the ?-chain of PINP.Type: ApplicationFiled: March 22, 2023Publication date: April 24, 2025Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shiomi HORIUCHI MORISHITA, Rikako OGASAWARA, Ryo SAHARA, Tomohide ASAI, Osamu MIYAZAKI
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Patent number: 12270823Abstract: There is provided an automated analysis device capable of transferring instruments to be used for an analysis process to a predetermined processing position efficiently and rapidly. In an automated analysis device of the invention, a transfer unit forming a transfer mechanism to transfer instruments to be used for analyte processing into an analyte processing space includes a holding portion to hold the instruments. The holding portion includes a first fitting attachment portion to be attachable to a first instrument in a fitted state, and a second fitting attachment portion to be attachable to a second instrument in a fitted state.Type: GrantFiled: December 23, 2021Date of Patent: April 8, 2025Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Kyoichi Iwahashi, Yasuo Minami, Tomohide Asai, Seiichiro Ishioka
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Patent number: 12265083Abstract: A problem to be solved is to improve the specificity of an anti-AIM antibody for free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for measuring an amount of free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an anti-AIM antibody in the presence of an anti-IgM antibody.Type: GrantFiled: January 30, 2020Date of Patent: April 1, 2025Assignees: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION “SAISEIKAI” IMPERIAL GIFT FOUNDATION INC.Inventors: Toru Miyazaki, Takeshi Okanoue, Tomohide Asai, Yuka Kanetsuki, Jiro Hirota
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Publication number: 20250035618Abstract: It is an object of the present invention to provide a method for suppressing non-specific reactions using a highly versatile method without affecting specific reactions. The present invention provides a detection method for detecting a target antigen in a sample using a specific antibody that specifically binds to the antigen, the method comprising: a) a step of bringing the sample into contact with a modified antibody; and b) a step of bringing the sample into contact with the specific antibody simultaneously with or after the step a), which is a highly versatile method that can suppress non-specific reactions.Type: ApplicationFiled: December 27, 2022Publication date: January 30, 2025Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Daisuke YAMADA, Ikumi SUZUKI, Kengo FUJIMURA, Tomohide ASAI, Osamu MIYAZAKI
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Publication number: 20240369543Abstract: A measurement reagent for a cross-linked N-telopeptide of type I collagen containing uric acid or its salt. This reagent is easier to handle and enables NTx measurement with higher accuracy.Type: ApplicationFiled: October 18, 2022Publication date: November 7, 2024Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Tomo SHIMIZU, Tomohide ASAI
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Publication number: 20240255505Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2 in a biological sample, including using two types of monoclonal antibodies or antibody fragments thereof that bind to a peptide fragment having 30 or less consecutive amino acids in a nucleocapsid protein of SARS-CoV-2, wherein the two types of monoclonal antibodies or antibody fragments thereof recognize different epitopesType: ApplicationFiled: June 16, 2022Publication date: August 1, 2024Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Jiro HIROTA, Satoru UNO, Yasushi OCHIAI, Shizuka ITO, Keisuke WATANABE, Shinya OKUYAMA, Tomohide ASAI
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Publication number: 20240241120Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2, including a step of contacting a biological sample with a monoclonal antibody or an antibody fragment thereof that binds to a nucleocapsid protein of SARS-COV-2, wherein the monoclonal antibody or the antibody fragment thereof binds to the SARS-CoV-2 treated with a serine protease.Type: ApplicationFiled: June 16, 2022Publication date: July 18, 2024Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Jiro HIROTA, Satoru UNO, Yasushi OCHIAI, Shohei YAJI, Christopher Kenta HEWSON, Keigo KOHNO, Tomohide ASAI
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Publication number: 20240125784Abstract: The problem addressed by the present invention is to provide an immunological assay method using a monoclonal antibody and a kit including the monoclonal antibody, which can be used for assaying ICTP without requiring special facilities. This problem can be solved by a method for immunological assay of type I collagen C-terminal telopeptide in a biological sample, including contacting type I collagen C-terminal telopeptide with a monoclonal antibody that recognizes an amino acid sequence represented by GFDFSFLP (SEQ ID NO: 1) as an epitope.Type: ApplicationFiled: March 23, 2022Publication date: April 18, 2024Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shiomi HORIUCHI MORISHITA, Rikako OGASAWARA, Tomohide ASAI, Osamu MIYAZAKI
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Publication number: 20230025583Abstract: A problem to be solved by the invention is to improve the sensitivity of measurement of an analyte in a sample by a sandwich immunoassay. The sensitivity can be improved significantly in a sandwich immunoassay using a first antibody and a second antibody when one or both of the first antibody and the second antibody are a mixture of a monoclonal antibody recognizing a linear epitope and a monoclonal antibody recognizing a conformational epitope.Type: ApplicationFiled: November 27, 2020Publication date: January 26, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Tomohide ASAI, Yoshihiro TANAKA, Ikumi SUZUKI, Satoko SEO, Tomoyuki USUI, Tomo SHIMIZU, Osamu MIYAZAKI
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Publication number: 20220146529Abstract: A problem to be solved is to detect only free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for free AIM in a biological sample using an anti-AIM monoclonal antibody having a property of reacting with free AIM and not reacting with complex AIM, wherein the anti-AIM monoclonal antibody is an antibody binding to an epitope in the SRCR2 domain of human AIM.Type: ApplicationFiled: January 30, 2020Publication date: May 12, 2022Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.Inventors: Toru MIYAZAKI, Tomoko YAMAZAKI, Takeshi OKANOUE, Tomohide ASAI, Yuka KANETSUKI, Jiro HIROTA
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Publication number: 20220120762Abstract: A problem to be solved is to further improve the specificity for free AIM of an antibody specifically reacting with free AIM and to diagnose NASH without imposing a burden on patients and medical staffs. The problem can be solved by an immunoassay method for free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an antibody specifically reacting with free AIM in a presence of an anti-IgM antibody.Type: ApplicationFiled: January 30, 2020Publication date: April 21, 2022Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.Inventors: Toru MIYAZAKI, Takeshi OKANOUE, Tomohide ASAI, Yuka KANETSUKI, Jiro HIROTA
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Publication number: 20220113332Abstract: There is provided an automated analysis device capable of transferring instruments to be used for an analysis process to a predetermined processing position efficiently and rapidly. In an automated analysis device of the invention, a transfer unit forming a transfer mechanism to transfer instruments to be used for analyte processing into an analyte processing space includes a holding portion to hold the instruments. The holding portion includes a first fitting attachment portion to be attachable to a first instrument in a fitted state, and a second fitting attachment portion to be attachable to a second instrument in a fitted state.Type: ApplicationFiled: December 23, 2021Publication date: April 14, 2022Inventors: Kyoichi IWAHASHI, Yasuo MINAMI, Tomohide ASAI, Seiichiro ISHIOKA
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Publication number: 20220113327Abstract: There is provided an automated analysis device capable of transferring a rack to a predetermined instrument extraction position efficiently and rapidly, the rack being loaded with instruments to be used for an analysis process. An automated analysis device of the invention includes a conveyance unit to raise and lower a plurality of racks in a vertically stacked state to convey the racks into an analyte processing space, the racks being loaded with instruments to be used for analyte processing. The conveyance unit includes a movement mechanism to move an uppermost rack from a rack standby position to an extraction position with guidance of a protrusion and a recess while maintaining a state of slidable protrusion and recess engagement between the uppermost rack and a rack below the uppermost rack.Type: ApplicationFiled: December 23, 2021Publication date: April 14, 2022Inventors: Seiichiro ISHIOKA, Yasuo MINAMI, Tomohide ASAI, Kyoichi IWAHASHI
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Publication number: 20220113329Abstract: There is provided an automated analysis device capable of transferring a reagent for reagent dispensing efficiently and rapidly. An automated analysis device of the invention includes a reagent transfer unit to transfer a reagent suction nozzle between a reaction unit and a reagent supply unit. In a region of an analyte processing space where a tip supply unit, the reagent supply unit, a tip disposal unit, and the reaction unit are lined up along a straight line, the reagent transfer unit forms a uniaxial transfer line where the reagent suction nozzle is moved only in a uniaxial direction along the straight line for a reagent transfer.Type: ApplicationFiled: December 23, 2021Publication date: April 14, 2022Inventors: Seiichiro ISHIOKA, Yasuo MINAMI, Tomohide ASAI, Kyoichi IWAHASHI
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Publication number: 20220107318Abstract: A problem to be solved is to improve the specificity of an anti-AIM antibody for free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for measuring an amount of free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an anti-AIM antibody in the presence of an anti-IgM antibody.Type: ApplicationFiled: January 30, 2020Publication date: April 7, 2022Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKA" IMPERIAL GIFT FOUNDATION INC.Inventors: Toru MIYAZAKI, Takeshi OKANOUE, Tomohide ASAI, Yuka KANETSUKI, Jiro HIROTA
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Publication number: 20210389326Abstract: A method and a diagnostic agent kit for detecting viral liver cancer having excellent sensitivity and specificity are provided. The problem can be solved by a method for detecting viral liver cancer, comprising measuring an amount of free AIM in a biological sample from a subject and comparing the measured amount of free AIM with a reference value.Type: ApplicationFiled: November 8, 2019Publication date: December 16, 2021Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.Inventors: Toru MIYAZAKI, Tomoko YAMAZAKI, Takeshi OKANOUE, Tomohide ASAI, Yuka KANETSUKI, Jiro HIROTA
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Patent number: 6893831Abstract: The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing thrombin and/or an antibody reacting with human fibrin-like related substances to the reagents. The immunoassay of the invention comprises the steps of adding thrombin and/or an antibody reacting with human fibrin-like related substances to the reagents, and measuring PIVKA-II in serum or plasma.Type: GrantFiled: June 1, 2000Date of Patent: May 17, 2005Assignee: Sanko Junyaku Co., Ltd.Inventors: Motohito Kanashima, Tomohide Asai, Hiroki Takahashi, Yoshiyuki Asai