Abstract: A device, a method, a program, and a recording medium with the program recorded thereon to calculate a difference in free energy between different molecules at a high speed with a high accuracy. The device, the method, the program, and the recording medium with the program recorded thereon calculate ?G based on the following numerical formula (1): ? ? ? G = ? ? ? ? P ? ( ? ) ? d ? ? ? + RT ? ? P ? ( ? ) ? log ? ( P ? ( ? ) P 0 ? ( ? ) ) ? d ? ? ? + ? ? ? ? v ? ( ? ) ? P ? ( ? ) ? d ? ? ? .

Abstract: A compound has a guanidine skeleton that inhibits the protease activity of MALT1 and exerts a therapeutic or prophylactic effect on autoimmune disease such as psoriasis or allergic disease such as atopic dermatitis. The guanidine derivative is typified by the following formula or a pharmacologically acceptable salt thereof.

Abstract: A compound has inhibitory activity on Discoidin Domain Receptor 1. The compound includes a urea derivative represented by the formula below or a pharmaceutically acceptable salt thereof.

Abstract: A compound has a guanidine skeleton that inhibits the protease activity of MALT1 and exerts a therapeutic or prophylactic effect on autoimmune disease such as psoriasis or allergic disease such as atopic dermatitis. The guanidine derivative is typified by the following formula or a pharmacologically acceptable salt thereof.

Abstract: A compound has inhibitory activity on Discoidin Domain Receptor 1. A urea derivative is represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein, R1 is trifluoromethyl, trifluoromethoxy, or pentafluorosulfanyl; each R2 is independently a hydrogen atom or methyl which is optionally substituted by one hydroxyl or one saturated heterocyclyl having four to six ring-forming atoms; R3 is a hydrogen atom, halogen atom, C1-C3 alkyl, saturated heterocyclyl having four to six ring-forming atoms and optionally having an oxo group, or R5O—; and R4 is phenyl, pyridyl, pyridazinyl, or pyrimidinyl, which phenyl, pyridyl, pyridazinyl, or pyrimidinyl is optionally substituted by one R6.

Abstract: A compound has inhibitory activity on Discoidin Domain Receptor 1. The compound includes a urea derivative represented by the formula below or a pharmaceutically acceptable salt thereof.

Abstract: A compound has inhibitory activity on Discoidin Domain Receptor 1. A urea derivative is represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein, R1 is trifluoromethyl, trifluoromethoxy, or pentafluorosulfanyl; each R2 is independently a hydrogen atom or methyl which is optionally substituted by one hydroxyl or one saturated heterocyclyl having four to six ring-forming atoms; R3 is a hydrogen atom, halogen atom, C1-C3 alkyl, saturated heterocyclyl having four to six ring-forming atoms and optionally having an oxo group, or R5O—; and R4 is phenyl, pyridyl, pyridazinyl, or pyrimidinyl, which phenyl, pyridyl, pyridazinyl, or pyrimidinyl is optionally substituted by one R6.

Abstract: A device, a method, a program, and a recording medium with the program recorded thereon to calculate a difference in free energy between different molecules at a high speed with a high accuracy. The device, the method, the program, and the recording medium with the program recorded thereon calculate ?G based on the following numerical formula (1): ? ? ? G = ? ? ? ? P ? ( ? ) ? d ? ? ? + RT ? ? P ? ( ? ) ? log ? ( P ? ( ? ) P 0 ? ( ? ) ) ? d ? ? ? + ? ? ? ? v ? ( ? ) ? P ? ( ? ) ? d ? ? ? .

Abstract: An object of the present invention is to provide a polyester film whose wet heat resistance is not reduced even when incorporated into a solar cell backsheet or solar cell. The polyester film according to the present invention has a peak count SPc_L (400 nm) of 100 to 700 and a peak count SPc_H (4,000 nm) of not more than 10 on at least one surface, the polyester film having an amount of terminal carboxyl groups of 0 to 20 eq/ton.

Abstract: [Problem] An object of the present invention is to provide a polyester film whose wet heat resistance is not reduced even when incorporated into a solar cell backsheet or solar cell. [Means for Solution] The polyester film according to the present invention has a peak count SPc (400 nm) of not less than 100 and a peak count SPc (4,000 nm) of not more than 10 on at least one surface, the polyester film having an amount of terminal carboxyl groups of 0 to 25 eq/ton.

Abstract: A polyester film has a laminate structure including a polyester layer (layer P1) containing a crystalline polyester and inorganic particles and a polyester layer (layer P2) containing a crystalline polyester, inorganic particles, and an antihydrolysis segment, wherein the content (Wa2) of the inorganic particles in the layer P2 is at least 10 mass % of the layer P2, the difference between the content (Wa2) (mass %) of the inorganic particles in the layer P2 and the content (Wa1) (mass %) of the inorganic particles in the layer P1, Wa2?Wa1, is 5 to 25 mass %, and the content (Wb2) of the antihydrolysis segment in the layer P2 is 0.02 to 1.5 mass % of the layer P2.

Abstract: A polyester film has a laminate structure including a polyester layer (layer P1) containing a crystalline polyester and inorganic particles and a polyester layer (layer P2) containing a crystalline polyester, inorganic particles, and an antihydrolysis segment, wherein the content (Wa2) of the inorganic particles in the layer P2 is at least 10 mass % of the layer P2, the difference between the content (Wa2) (mass %) of the inorganic particles in the layer P2 and the content (Wa1) (mass %) of the inorganic particles in the layer P1, Wa2?Wa1, is 5 to 25 mass %, and the content (Wb2) of the antihydrolysis segment in the layer P2 is 0.02 to 1.5 mass % of the layer P2.