Patents by Inventor Tomohiko Makiyama

Tomohiko Makiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ceramide derivative and Golgi apparatus-labeling fluorescent probe using same
    Patent number: 9207232
    Abstract: A measure for selective fluorescent labeling of the Golgi apparatus, which has low cytotoxicity and excellent intracellular stability, is provided. According to the present invention, provided are a ceramide derivative represented by the following Chemical formula 1: in the formula, R1 is an alkyl group having 1 to 12 carbon atoms, R2 is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 1 to 20, and a Golgi apparatus-labeling fluorescent probe using the same.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: December 8, 2015
    Assignee: National University Corporation Chiba University
    Inventors: Atsushi Nishida, Hiroyuki Nakamura, Tomohiko Makiyama, Toshihiko Murayama
  • CERAMIDE DERIVATIVE AND GOLGI APPARATUS-LABELING FLUORESCENT PROBE USING SAME
    Publication number: 20140329266
    Abstract: A measure for selective fluorescent labeling of the Golgi apparatus, which has low cytotoxicity and excellent intracellular stability, is provided. According to the present invention, provided are a ceramide derivative represented by the following Chemical formula 1: in the formula, R1 is an alkyl group having 1 to 12 carbon atoms, R2 is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 1 to 20, and a Golgi apparatus-labeling fluorescent probe using the same.
    Type: Application
    Filed: August 13, 2012
    Publication date: November 6, 2014
    Applicant: National University Corporation Chiba University
    Inventors: Atsushi Nishida, Hiroyuki Nakamura, Tomohiko Makiyama, Toshihiko Murayama