Abstract: Antibiotics Y-16482 .alpha. and/or Y-16482 .beta., obtained by cultivating a strain belonging to the genus Pseudomonas and capable of producing Y-16482, process of producing either or both of them, and a pharmaceutical composition containing these compounds. Antibiotics Y-16482 .alpha. and/or Y-16482 .beta. show an antibacterial activity to gram-positive and gram-negative bacteria and indicate an antitumor activity to experimental tumors.

Abstract: A polycondensation product of a germanium trihydroxide compound of the formula: ##STR1## wherein W is hydrogen, alkyl, halogen, alkoxycarbonyl, carboxy, aryl, cycloalkyl which may be substituted, cycloalkenyl, heteroaryl or a group of the formula: (R.sup.1)(R.sup.2)N-- wherein R.sup.1 and R.sup.2 are each lower alkyl or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a group of the formula: ##STR2## wherein R.sup.3 is hydrogen, lower alkyl, phenyl which may be substituted, aralkyl, acyl, acylamino or heteroaryl, and X is --N.dbd., --CH.dbd. or ##STR3## A is a bond, alkylene, alkenylene, --CO--Y--, --CONH--Y--, --O--Y--, --S--Y-- or ##STR4## (Y is alkylene); and R is alkyl. Such compounds are useful as agents for treating immune diseases.

Abstract: A heterocyclic compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxycarbonyl, formyl, nitroso, acyl, phenacyl, aralkyl, .alpha.-(benzyloxycarbonyl)benzyl or .alpha.-carboxybenzyl; each of R.sup.2 and R.sup.3 is hydrogen, C.sub.1-4 alkyl or aryl; and all of R.sup.4, R.sup.5 and R.sup.6 are hydrogens, or both R.sup.1 and R.sup.6, and R.sup.4 and R.sup.5 together form single bonds; in which definitions the term "acyl", "phenacyl", "aralkyl" or "aryl" means that it may be substituted by at least one substituent at any position(s) on the aromatic nucleus, each substituent being independently selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxyl, phenyl, nitro, trifluoromethyl, methylthio, methanesulfonyl and methylenedioxy. Such compounds are useful as drugs for treating immune diseases.