Abstract: Provided are an iminopyridine derivative having a selective ?1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an ?1D adrenergic receptor antagonistic action. An ?1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an ?1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.

Abstract: The present invention provides a novel pyrazole derivative and an androgen receptor antagonist containing the derivative. The present invention provides a compound represented by the formula (I?) wherein R1 is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom, or a group via a sulfur atom; R2 is a phenyl group having cyano (the phenyl group may further have substituent(s) other than cyano); R3 is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom, or a group via a sulfur atom; R4 is a cyclic group optionally having substituent(s); and X is methylene optionally having substituent(s), or CO, or a salt thereof.

Abstract: Provided are an iminopyridine derivative having a selective ?1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an ?1D adrenergic receptor antagonistic action. An ?1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an ?1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.

Abstract: The present invention aims to provide a novel pyrazole derivative and a pharmaceutical agent containing the same.

Abstract: The present invention provides a novel pyrazole derivative and an androgen receptor antagonist containing the derivative. The present invention provides a compound represented by the formula (I?) wherein R1 is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom, or a group via a sulfur atom; R2 is a phenyl group having cyano (the phenyl group may further have substituent(s) other than cyano); R3 is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom, or a group via a sulfur atom; R4 is a cyclic group optionally having substituent(s); and X is methylene optionally having substituent(s), or CO, or a salt thereof.

Abstract: An electric screen device for preventing creatures from intruding into a water channel, which comprises a pair of opposed electrode assemblies disposed on opposite sides of a water intake channel, and a dc pulse applying device 13 for applying dc pulses between the electrode assemblies. In such electric screen device, the product of the peak value of the intensity of an electric field produced between the electrode assemblies by the dc pulse applying device and the body length of creatures to be prevented from intrusion into the water channel is not less than 0.1 V, the dc pulse applying time is within the range of 2-200 msec, and the duty factor of the dc pulse is not more than 0.5.

Abstract: The present invention discloses a method of continuously processing a ribbonlike material. The method is characterized by comprising a preliminary polishing step in which surface defects of a material pulled out from an uncoiler are removed and the surface of the material is semi-finished by abrasion in combination with electrolytic polishing, a final polishing step in which the surface of the material is mirror-finished by abrasion in combination with electrolytic polishing, a washing and drying step in which the material is washed and dried with extraneous matter on the surface of the material washingly removed, a surface inspection step in which the thus finished surface of the material is inspected as to surface roughness and defects, a surface protection step in which a protective film is applied to the finished surface of the material, and a press step in which the material is cut into a predetermined size.

Abstract: The present application discloses an equipment for continuously processing a band-shape material comprising transverse sliding shafts disposed on a base table, a basal board which freely slides transversely along said transverse sliding shafts, transverse-feeding means by which said basal board is quickly and/or slowly moved transversely, vertical sliding shafts disposed on said basal board, a tool of abrasion in combination with elctrolytic polishing which freely slides vertically along said vertical sliding shafts, vertical-feeding means by which said tool is moved vertically against said basal board and a polishing head which is disposed on said tool and composed of electrodes for electrolysis and abrasive matters for abrasion and by which continuously sent band-shape material is polished.