Patents by Inventor Tomohiko Yoshitake
Tomohiko Yoshitake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230174573Abstract: An object of the present invention is to suppress the variation of the elution position of a compound having a charged portion by a preservation liquid, in the purification of the compound, without carrying out the substitution step of the preservation liquid attached to the adsorbent used for the purification and the keeping step. A method for purifying a compound having a charged portion, the method comprising the steps of: preparing a composition containing a compound having a charged portion; preparing a buffer solution comprising a buffering agent and an alcohol, the buffer containing a calcium phosphate compound at least partially, having a buffer capacity in a range of pH 6.0 to pH 8.Type: ApplicationFiled: May 1, 2020Publication date: June 8, 2023Applicant: HOYA TECHNOSURGICAL CORPORATIONInventor: Tomohiko YOSHITAKE
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Publication number: 20230149902Abstract: [Problems] To provide a method for treating hydroxyapatite filler so that it can be used multiple times in the separation of a charged material included in a sample liquid using adsorbent composed of the hydroxyapatite filler, a production method including the treatment method, and hydroxyapatite filler. [Means to solve problems] The treatment method of the present invention comprises a first step of bringing a first liquid containing a predetermined material into contact with hydroxyapatite filler, and a second step of bringing a second liquid containing an alcohol into contact with the hydroxyapatite filler.Type: ApplicationFiled: April 7, 2020Publication date: May 18, 2023Applicant: HOYA TECHNOSURGICAL CORPORATIONInventors: Machiko KATO, Tomohiko YOSHITAKE
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Patent number: 10407306Abstract: A method of producing fluoroapatite powder by using a calcium compound, a phosphate compound, and a fluorine compound as a raw material is provided. The method comprises: preparing a slurry containing fluoroapatite produced from the raw material by using a wet process; applying an ultrasonic wave to the slurry; and drying the slurry to obtain the fluoroapatite powder mainly constituted of the fluoroapatite. The method provides fluoroapatite powder having improved particle strength. Further, an adsorption apparatus including the fluoroapatite powder is also provided.Type: GrantFiled: September 29, 2009Date of Patent: September 10, 2019Assignee: HOYA CORPORATIONInventors: Tsuyoshi Ishikawa, Yoshiyuki Ogawara, Tomohiko Yoshitake, Yukiko Murakami
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Patent number: 8609055Abstract: A method of producing fluoroapatite by using a calcium-based compound containing calcium, hydrogen fluoride and phosphoric acid is provided. The method can be produced fluoroapatite having improved acid resistance by reducing an amount of an impurity derived from a raw material to a low or very low level, and ability capable of separating a large amount of a protein due to a large specific surface area thereof. Further, fluoroapatite having high acid resistance and a large specific surface area is also provided. Furthermore, an adsorption apparatus using such fluoroapatite is also provided.Type: GrantFiled: August 27, 2008Date of Patent: December 17, 2013Assignee: Hoya CorporationInventors: Tsuyoshi Ishikawa, Yoshiyuki Ogawara, Tomohiko Yoshitake, Yukiki Murakami
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Patent number: 7837872Abstract: An adsorption apparatus comprising a column filled with an adsorbent, wherein the surface of the adsorbent and its vicinity mainly comprise an apatite which is represented by the formula (Ca1-aMa)10(PO4)6((OH)1-bXb)2, where the M represents at least one kind of rare earth metal elements, the X represents at least one kind of halogen elements, 0<a?1, and 0?b?1. Preferably, the M comprises a lanthanide-based metal element mainly comprising Sm, and the ratio of Sm is no less than 70% to the total amount of the M. The adsorbent apparatus may be manufactured by passing a solution containing ions of at least one kind of rare earth metal elements through the adsorbent filling space of the column filled with the apatite represented by the formula Ca10(PO4)6((OH)1-bXb)2, where the X represents at least one kind of halogen elements and 0?b?1.Type: GrantFiled: March 7, 2006Date of Patent: November 23, 2010Assignees: Hoya CorporationInventors: Shintaro Kobayashi, Tomohiko Yoshitake, Naomi Masuzawa, Tsuneo Okuyama
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Publication number: 20100255306Abstract: A method of producing fluoroapatite powder by using a calcium compound, a phosphate compound, and a fluorine compound as a raw material is provided. The method comprises: preparing a slurry containing fluoroapatite produced from the raw material by using a wet process; applying an ultrasonic wave to the slurry; and drying the slurry to obtain the fluoroapatite powder mainly constituted of the fluoroapatite. The method provides fluoroapatite powder having improved particle strength. Further, an adsorption apparatus including the fluoroapatite powder is also provided.Type: ApplicationFiled: September 29, 2009Publication date: October 7, 2010Applicant: HOYA CORPORATIONInventors: Tsuyoshi ISHIKAWA, Yoshiyuki OGAWARA, Tomohiko YOSHITAKE, Yukiko MURAKAMI
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Patent number: 7767179Abstract: A method for producing an adsorbent which is stable toward a liquid such as an eluant and which shows excellent reproducibility in selectively adsorbing and separating an object compound, the method includes the steps of: preparing a base material having a surface, in which at least part of the surface of the base material is formed of a material containing as its major component apatite which is represented by the composition formula Ca10(PO4)6((OH)1-aXa)2; preparing a solution containing ions of at least one metal element; substituting at least part of Ca of the apatite by the at least one metal element by bringing the base material into contact with the solution to obtain a substituted base material; and subjecting the substituted base material to heat treatment at 50 to 400° C. for 0.5 to 10 hours, wherein the base material and the substituted base material are not exposed to a temperature exceeding 500° C. for 4 hours or longer from the substitution step to the completion of production of the adsorbent.Type: GrantFiled: November 14, 2006Date of Patent: August 3, 2010Assignee: Hoya CorporationInventors: Tomohiko Yoshitake, Shintaro Kobayashi
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Patent number: 7740820Abstract: A method of producing a fluoroapatite is provided. The method comprises preparing a slurry containing a hydroxyapatite which has at least one hydroxyl group, preparing a hydrogen fluoride-containing solution containing a hydrogen fluoride, mixing the hydrogen fluoride-containing solution with the slurry to obtain a mixture to thereby adjust a pH of the mixture in the range of 2.5 to 5, and reacting the hydroxyapatite with the hydrogen fluoride in the mixture in a state that the pH of the mixture is adjusted within the above range to thereby obtain the fluoroapatite by substituting the at least one hydroxyl group of the hydroxyapatite with fluorine atom of the hydrogen fluoride. The method can produce the fluoroapatite having improved acid resistance by reducing an impurity, such as ammonia, derived from a raw material to a low or very low level. Further, a fluoroapatite having high acid resistance is also provided. Furthermore, an adsorption apparatus using such a fluoroapatite is provided.Type: GrantFiled: August 1, 2008Date of Patent: June 22, 2010Assignee: Hoya CorporationInventors: Tsuyoshi Ishikawa, Yoshiyuki Ogawara, Tomohiko Yoshitake, Yukiko Murakami
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Publication number: 20100130353Abstract: A method of producing a fluoroapatite is provided. The method comprises preparing a slurry containing a hydroxyapatite which has at least one hydroxyl group, preparing a hydrogen fluoride-containing solution containing a hydrogen fluoride, mixing the hydrogen fluoride-containing solution with the slurry to obtain a mixture to thereby adjust a pH of the mixture in the range of 2.5 to 5, and reacting the hydroxyapatite with the hydrogen fluoride in the mixture in a state that the pH of the mixture is adjusted within the above range to thereby obtain the fluoroapatite by substituting the at least one hydroxyl group of the hydroxyapatite with fluorine atom of the hydrogen fluoride. The method can produce the fluoroapatite having improved acid resistance by reducing an impurity, such as ammonia, derived from a raw material to a low or very low level. Further, a fluoroapatite having high acid resistance is also provided. Furthermore, an adsorption apparatus using such a fluoroapatite is provided.Type: ApplicationFiled: January 29, 2010Publication date: May 27, 2010Applicant: HOYA CorporationInventors: Tsuyoshi ISHIKAWA, Yoshiyuki Ogawara, Tomohiko Yoshitake, Yukiko Murakami
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Publication number: 20090215997Abstract: A method of separating a fluorescent protein from a sample containing a plurality of proteins containing the fluorescent protein is provided.Type: ApplicationFiled: February 19, 2009Publication date: August 27, 2009Applicants: HOYA CORPORATIONInventors: Ken SUGO, Tomohiko YOSHITAKE, Tsuneo OKUYAMA
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Publication number: 20090148376Abstract: A method of producing a fluoroapatite is provided. The method comprises preparing a slurry containing a hydroxyapatite which has at least one hydroxyl group, preparing a hydrogen fluoride-containing solution containing a hydrogen fluoride, mixing the hydrogen fluoride-containing solution with the slurry to obtain a mixture to thereby adjust a pH of the mixture in the range of 2.5 to 5, and reacting the hydroxyapatite with the hydrogen fluoride in the mixture in a state that the pH of the mixture is adjusted within the above range to thereby obtain the fluoroapatite by substituting the at least one hydroxyl group of the hydroxyapatite with fluorine atom of the hydrogen fluoride. The method can produce the fluoroapatite having improved acid resistance by reducing an impurity, such as ammonia, derived from a raw material to a low or very low level. Further, a fluoroapatite having high acid resistance is also provided. Furthermore, an adsorption apparatus using such a fluoroapatite is provided.Type: ApplicationFiled: August 1, 2008Publication date: June 11, 2009Applicant: HOYA CORPORATIONInventors: Tsuyoshi ISHIKAWA, Yoshiyuki OGAWARA, Tomohiko YOSHITAKE, Yukiko MURAKAMI
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Publication number: 20090087369Abstract: Fluoroapatite dried particles are obtained by reacting hydroxyapatite primary particles having hydroxyl groups and hydrogen fluoride molecules having fluorine atoms so that at least one of hydroxyl groups of hydroxyapatite primary particles are substituted by the fluorine atoms of the hydrogen fluoride molecules. The fluoroapatite dried particles can exhibit superior acid resistance. Further, an adsorption apparatus using such fluoroapatite dried particles is provided.Type: ApplicationFiled: September 29, 2008Publication date: April 2, 2009Applicant: HOYA CORPORATIONInventors: Tsuyoshi ISHIKAWA, Yoshiyuki OGAWARA, Tomohiko YOSHITAKE, Yukiko MURAKAMI
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Publication number: 20090060814Abstract: A method of producing fluoroapatite by using a calcium-based compound containing calcium, hydrogen fluoride and phosphoric acid is provided. The method can be produced fluoroapatite having improved acid resistance by reducing an amount of an impurity derived from a raw material to a low or very low level, and ability capable of separating a large amount of a protein due to a large specific surface area thereof. Further, fluoroapatite having high acid resistance and a large specific surface area is also provided. Furthermore, an adsorption apparatus using such fluoroapatite is also provided.Type: ApplicationFiled: August 27, 2008Publication date: March 5, 2009Applicant: HOYA CORPORATIONInventors: Tsuyoshi ISHIKAWA, Yoshiyuki OGAWARA, Tomohiko YOSHITAKE, Yukiko MURAKAMI
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Publication number: 20090039026Abstract: A method of separating at least one phycobilino-based pigment from a sample containing a plurality of phycobilin-based pigments is provided. The method is capable of separating a specific phycobilin-based pigment with high purity by a simple operation.Type: ApplicationFiled: July 25, 2008Publication date: February 12, 2009Applicants: HOYA CORPORATION, Tsuneo OKUYAMAInventors: Shintaro Kobayashi, Tomohiko Yoshitake, Tsuneo Okuyama
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Publication number: 20070107600Abstract: A method for producing an adsorbent which is stable toward a liquid such as an eluant and which shows excellent reproducibility in selectively adsorbing and separating an object compound, the method includes the steps of: preparing a base material having a surface, in which at least part of the surface of the base material is formed of a material containing as its major component apatite which is represented by the composition formula Ca10(PO4)6((OH)1?aXa)2; preparing a solution containing ions of at least one metal element; substituting at least part of Ca of the apatite by the at least one metal element by bringing the base material into contact with the solution to obtain a substituted base material; and subjecting the substituted base material to heat treatment at 50 to 400° C. for 0.5 to 10 hours, wherein the base material and the substituted base material are not exposed to a temperature exceeding 500° C. for 4 hours or longer from the substitution step to the completion of production of the adsorbent.Type: ApplicationFiled: November 14, 2006Publication date: May 17, 2007Applicant: PENTAX CorporationInventors: Tomohiko Yoshitake, Shintaro Kobayashi
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Publication number: 20060207940Abstract: An adsorption apparatus has a column having an adsorbent filling space filled with an adsorbent. The adsorbent has a surface and its vicinity mainly comprises an apatite which is represented by the formula (Ca1-aMa)10(PO4)6((OH)1-bXb)2, where the M represents at least one kind of rare earth metal elements, the X represents at least one kind of halogen elements, 0<a?1, and 0?b?1. Preferably, the M comprises a lanthanoid-based metal element mainly comprises Sm, and the ratio of Sm is no less than 70% to the total amount of the M. This ensures that an object compound having a portion capable of bonding to the M with a high affinity is specifically bonded to the adsorbent. As a result, the adsorbent can exhibit high selectivity with respect to such a compound.Type: ApplicationFiled: March 7, 2006Publication date: September 21, 2006Applicants: PENTAX CorporationInventors: Shintaro Kobayashi, Tomohiko Yoshitake, Naomi Masuzawa, Tsuneo Okuyama