Patents by Inventor Tomohiro Akeboshi

Tomohiro Akeboshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing acyloxypyranone compound, method for producing alkyne compound, and method for producing dihydrofuran compound
    Patent number: 8927237
    Abstract: An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R1 represents an acyl group). Then, an acetylene organic metal compound represented by formula (III) (wherein R2 represents a hydrogen atom or a tri-substituted silyl group, and M represents an alkali metal atom, aluminum, or a magnesium monohalide) and a coordinating additive are caused to act on the acyloxypyranone compound represented by formula (II), to thereby produce an alkyne compound represented by formula (IV). The alkyne compound represented by formula (IV) is hydrolyzed with acid, to thereby produce a dihydrofuran compound represented by formula (V).
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: January 6, 2015
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Yoshikazu Ootsuka, Tomohiro Akeboshi, Akiko Yamazaki, Yusuke Iriyama
  • Process for production of bicyclo[2.2.2]octylamine derivative
    Patent number: 8476470
    Abstract: The present invention herein provides a process for production of a bicyclo[2.2.2]octylamine derivative which may be used as an intermediate for preparation of medical and pharmaceutical products. The process is quite efficient and can produce the derivative in a large-scale while using mild reaction conditions. The process for producing a bicyclo[2.2.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: July 2, 2013
    Assignee: Kyorin Pharmaceutical Co., Ltd.
    Inventors: Tomohiro Akeboshi, Yusuke Iriyama, Hirotaka Kawanami
  • METHOD FOR PRODUCING ACYLOXYPYRANONE COMPOUND, METHOD FOR PRODUCING ALKYNE COMPOUND, AND METHOD FOR PRODUCING DIHYDROFURAN COMPOUND
    Publication number: 20130023018
    Abstract: An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R1 represents an acyl group). Then, an acetylene organic metal compound represented by formula (III) (wherein R2 represents a hydrogen atom or a tri-substituted silyl group, and M represents an alkali metal atom, aluminum, or a magnesium monohalide) and a coordinating additive are caused to act on the acyloxypyranone compound represented by formula (II), to thereby produce an alkyne compound represented by formula (IV). The alkyne compound represented by formula (IV) is hydrolyzed with acid, to thereby produce a dihydrofuran compound represented by formula (V).
    Type: Application
    Filed: April 7, 2011
    Publication date: January 24, 2013
    Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Yoshikazu Ootsuka, Tomohiro Akeboshi, Akiko Yamazaki, Yusuke Iriyama
  • PROCESS FOR PRODUCTION OF BICYCLO[2.2.2]OCTYLAMINE DERIVATIVE
    Publication number: 20110137070
    Abstract: The present invention herein provides a process for production of a bicyclo[2.2.2]octylamine derivative which may be used as an intermediate for preparation of medical and pharmaceutical products. The process is quite efficient and can produce the derivative in a large-scale while using mild reaction conditions. The process for producing a bicyclo[2.2.
    Type: Application
    Filed: August 7, 2009
    Publication date: June 9, 2011
    Inventors: Tomohiro Akeboshi, Yusuke Iriyama, Hirotaka Kawanami