Patents by Inventor Tomohiro Aoki

Tomohiro Aoki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210113529
    Abstract: Provided is a pharmaceutical for preventing or treating an ophthalmic disease associated with intraocular neovascularization and/or increased intraocular vascular permeability. The inventors of the present invention have made investigations on a pharmaceutical for preventing or treating an ophthalmic disease associated with intraocular neovascularization and/or increased intraocular vascular permeability, and have confirmed that a selective S1P receptor agonist having agonist activity at an S1P1 receptor has an intraocular neovascularization-reducing action and an intraocular vascular permeability-reducing action, thus completing the present invention.
    Type: Application
    Filed: February 1, 2019
    Publication date: April 22, 2021
    Applicants: KYOTO UNIVERSITY, Astellas Pharma Inc.
    Inventors: Hideaki HARA, Shuh NARUMIYA, Tomohiro AOKI, Ichiro ARAMORI, Rie YAMAMOTO
  • Publication number: 20210001392
    Abstract: An aggregate mixture for a mold, the aggregate mixture including an aggregate, a water-soluble binder, a water-soluble foaming agent, an aqueous mold release agent, and water.
    Type: Application
    Filed: March 20, 2019
    Publication date: January 7, 2021
    Inventors: Tomohiro Aoki, Yusuke Kato, Hiroyuki Matsubara
  • Patent number: 10668524
    Abstract: To provide a binder composition for molding, by which a mold made of aggregate has an excellent resistance to moisture. The binder composition for molding contains a water-soluble binder and at least one kind of lithium salt that is selected from a group of lithium silicate, lithium oxide, lithium hydroxide, lithium carbonate, lithium bromide, lithium chloride, lithium nitrate, and lithium nitrite.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: June 2, 2020
    Assignee: Sintokogio, Ltd.
    Inventors: Tomohiro Aoki, Yusuke Kato
  • Publication number: 20190105703
    Abstract: To provide a binder composition for molding, by which a mold made of aggregate has an excellent resistance to moisture. The binder composition for molding contains a water-soluble binder and at least one kind of lithium salt that is selected from a group of lithium silicate, lithium oxide, lithium hydroxide, lithium carbonate, lithium bromide, lithium chloride, lithium nitrate, and lithium nitrite.
    Type: Application
    Filed: February 14, 2017
    Publication date: April 11, 2019
    Applicant: SINTOKOGIO, LTD.
    Inventors: Tomohiro AOKI, Yusuke KATO
  • Patent number: 10035181
    Abstract: To provide an apparatus for reclaiming foundry sand and a method for reclaiming foundry sand that can effectively remove binders and so on that attach to returned foundry sand that has been used. Foundry sand that has been used is supplied from a chute for feeding sand 14A to a rotor 16. The rotor 16 is rotated by a driver 20 so that frictional force is generated on the sand in the rotor 16. Then, the sand in the rotor 16 is dropped into the container for washing with water 30 that is located below the rotor 16. In the container for washing with water 30, an agitator 34 is rotated by the driver 20 so that the sand in the container for washing with water 30 is agitated and washed with water.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: July 31, 2018
    Assignee: SINTOKOGIO, LTD.
    Inventors: Yusuke Kato, Toshihiko Zenpo, Tomohiro Aoki, Takehiko Matsumoto, Takumi Maegawa, Hirotsune Watanabe, Tomokazu Suda, Masaomi Mitsutake, Hisao Nakane
  • Patent number: 9789533
    Abstract: Sand for a casting mold including sand, a binder, and an inorganic compound particle having poor water solubility and generating a gas, which is at least one of water vapor or carbon dioxide gas, by heat from a molten metal.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: October 17, 2017
    Assignees: SINTOKOGIO, LTD., TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Tomohiro Aoki, Yusuke Kato, Takehiko Matsumoto, Kenichiro Mori, Toshihiko Zenpo, Tomokazu Suda, Masaomi Mitsutake, Takumi Maegawa, So Nakayama, Masashi Morikawa, Hirotsune Watanabe
  • Patent number: 9629834
    Abstract: Provided is a pharmaceutical composition which enables the inhibition of formation and/or enlargement of cerebral aneurysm or the regression of cerebral aneurysm. The pharmaceutical composition for the inhibition of formation and/or enlargement of cerebral aneurysm or for the regression of cerebral aneurysm of the present invention, which includes a S1P1 receptor agonist as an active ingredient, enables the inhibition of formation and/or enlargement of cerebral aneurysm or the regression of cerebral aneurysm, and enables the prevention and/or treatment of a disease associated with cerebral aneurysm.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: April 25, 2017
    Assignees: KYOTO UNIVERSITY, ASTELLAS PHARMA INC.
    Inventors: Tomohiro Aoki, Ichiro Aramori, Jun Hirose, Rie Yamamoto
  • Publication number: 20160121388
    Abstract: Sand for a casting mold including sand, a binder, and an inorganic compound particle having poor water solubility and generating a gas, which is at least one of water vapor or carbon dioxide gas, by heat from a molten metal.
    Type: Application
    Filed: November 8, 2013
    Publication date: May 5, 2016
    Inventors: Tomohiro AOKI, Yusuke KATO, Takehiko MATSUMOTO, Kenichiro MORI, Toshihiko ZENPO, Tomokazu SUDA, Masaomi MITSUTAKE, Takumi MAEGAWA, So NAKAYAMA, Masashi MORIKAWA, Hirotsune WATANABE
  • Publication number: 20160113917
    Abstract: Provided is a pharmaceutical composition which enables the inhibition of formation and/or enlargement of cerebral aneurysm or the regression of cerebral aneurysm. The pharmaceutical composition for the inhibition of formation and/or enlargement of cerebral aneurysm or for the regression of cerebral aneurysm of the present invention, which includes a S1P1 receptor agonist as an active ingredient, enables the inhibition of formation and/or enlargement of cerebral aneurysm or the regression of cerebral aneurysm, and enables the prevention and/or treatment of a disease associated with cerebral aneurysm.
    Type: Application
    Filed: April 22, 2014
    Publication date: April 28, 2016
    Applicants: KYOTO UNIVERSITY, ASTELLAS PHARMA INC.
    Inventors: Tomohiro AOKI, Ichiro ARAMORI, Jun HIROSE, Rie YAMAMOTO
  • Publication number: 20150096594
    Abstract: To provide an apparatus for reclaiming foundry sand and a method for reclaiming foundry sand that can effectively remove binders and so on that attach to returned foundry sand that has been used. Foundry sand that has been used is supplied from a chute for feeding sand 14A to a rotor 16. The rotor 16 is rotated by a driver 20 so that frictional force is generated on the sand in the rotor 16. Then, the sand in the rotor 16 is dropped into the container for washing with water 30 that is located below the rotor 16. In the container for washing with water 30, an agitator 34 is rotated by the driver 20 so that the sand in the container for washing with water 30 is agitated and washed with water.
    Type: Application
    Filed: April 12, 2013
    Publication date: April 9, 2015
    Inventors: Yusuke Kato, Toshihiko Zenpo, Tomohiro Aoki, Takehiko Matsumoto, Takumi Maegawa, Hirotsune Watanabe, Tomokazu Suda, Masaomi Mitsutake, Hisao Nakane
  • Patent number: 8578710
    Abstract: A cup seal (21) of the invention includes an intermediate lip portion (21d), positioned between an inner lip portion (21b) and an outer lip portion (21c), provided in a base portion (21a). The intermediate lip portion (21d) is configured in such a way that first intermediate lip portions (21d1), communication passages (21d3), second intermediate lip portions (21d2), whose axial direction length is less than that of the first intermediate lip portions (21d1), and the communication passages (21d3), which have no lip portion, are cyclically disposed, in this order, in the peripheral direction. An easy elastic deformation portion of the base portion (21a) which elastically deforms easily is formed by the second intermediate lip portions (21d2) and communication passages (21d3) and, by the easy elastic deformation portion elastically deforming easily when supplying liquid, a flow passage with a larger passage area is formed.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: November 12, 2013
    Assignee: Bosch Corporation
    Inventors: Tomohiro Aoki, Masaki Shiwa
  • Patent number: 8407996
    Abstract: A projection (21b4) provided at a tip portion of an inner lip portion (21b) of a first cup seal (21) comes in contact with a second side wall (20c) of a recessed portion (20) and a large axial force is exerted in the axial direction on a first tapered inner peripheral surface (21b1) of the first cup seal (21) from a rear side tapered surface (4b2) of a primary piston (4). This makes it possible to reliably hold the first cup seal (21) in the axial direction by utilizing the axial force. Therefore, the first cup seal (21) can be suppressed from moving in the axial direction. In particular, the projection (21b4) of the first cup seal (21) comes in contact with a tapered surface (20c?) of the second side wall (20c) to obtain a further increased axial force, and the first cup seal (21) can be held more reliably.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: April 2, 2013
    Assignee: Bosch Corporation
    Inventors: Tomohiro Aoki, Masaki Shiwa, Kazuhisa Taira
  • Publication number: 20110209472
    Abstract: A cup seal (21) of the invention includes an intermediate lip portion (21d), positioned between an inner lip portion (21b) and an outer lip portion (21c), provided in a base portion (21a). The intermediate lip portion (21d) is configured in such a way that first intermediate lip portions (21d1), communication passages (21d3), second intermediate lip portions (21d2), whose axial direction length is less than that of the first intermediate lip portions (21d1), and the communication passages (21d3), which have no lip portion, are cyclically disposed, in this order, in the peripheral direction. An easy elastic deformation portion of the base portion (21a) which elastically deforms easily is formed by the second intermediate lip portions (21d2) and communication passages (21d3) and, by the easy elastic deformation portion elastically deforming easily when supplying liquid, a flow passage with a larger passage area is formed.
    Type: Application
    Filed: January 17, 2008
    Publication date: September 1, 2011
    Inventors: Tomohiro Aoki, Masaki Shiwa
  • Publication number: 20110092484
    Abstract: [Problems] To provide a medicament which is effective for treatment and prophylaxis of cerebral aneurysms [Means for Solving the Problems] The invention provides a medicament for treatment and prophylaxis of cerebral aneurysms, wherein the medicament contains a cysteine protease inhibitor as an active ingredient. The cysteine protease inhibitor preferably is an epoxysuccinamide derivative or its salt.
    Type: Application
    Filed: June 6, 2008
    Publication date: April 21, 2011
    Applicant: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Nobuo Hashimoto, Hiroharu Kataoka, Tomohiro Aoki
  • Publication number: 20100295220
    Abstract: Provided is a multi-leaf spring-type vibration damping device capable of suppressing the resonance caused by rotations near the major critical speed of a rotating shaft system and suppressing self-excited vibrations due to rotations at or higher than the major critical speed of the rotating shaft system. In the multi-leaf spring-type vibration damping device, a bearing (9) of a rotating shaft system (6) that includes at least a rotating shaft (4) fit in the bearing and a rotor (5) mounted on the rotating shaft is clamped between a plurality of fixedly mounted and properly spaced-apart multi-leaf springs (11) at the portions near their distal ends, or the plurality of multi-leaf springs contact at those portions near the distal ends with the bearing, thereby to suppress the whirling vibrations of the bearing.
    Type: Application
    Filed: January 10, 2007
    Publication date: November 25, 2010
    Inventors: Masaya Hotta, Hirohide Ishiguro, Hideki Morimitsu, Masahiko Nagasaka, Tomohiro Aoki
  • Publication number: 20100212313
    Abstract: A projection (21b4) provided at a tip portion of an inner lip portion (21b) of a first cup seal (21) comes in contact with a second side wall (20c) of a recessed portion (20) and a large axial force is exerted in the axial direction on a first tapered inner peripheral surface (21b1) of the first cup seal (21) from a rear side tapered surface (4b2) of a primary piston (4). This makes it possible to reliably hold the first cup seal (21) in the axial direction by utilizing the axial force. Therefore, the first cup seal (21) can be suppressed from moving in the axial direction. In particular, the projection (21b4) of the first cup seal (21) comes in contact with a tapered surface (20c?) of the second side wall (20c) to obtain a further increased axial force, and the first cup seal (21) can be held more reliably.
    Type: Application
    Filed: October 16, 2007
    Publication date: August 26, 2010
    Inventors: Tomohiro Aoki, Masaki Shiwa, Kazuhisa Taira
  • Publication number: 20100066028
    Abstract: In a cup seal, the hydraulic pressure in a first hydraulic chamber (6) causes a first seal portion (21e) of an outer lip portion (21c) to closely contact to a bottom wall (20a) of a recessed portion (20) and causes a second seal portion (21f) of a base portion (21a) to closely contact to a rear surface (20b) of the recessed portion (20). A double seal due to the first and second seal portions (21e) and (21f) reliably prevents the leakage of a brake fluid from the first hydraulic chamber (6). If the pressure becomes negative in the first hydraulic chamber (6), the tip portion of the outer lip portion (21c) deflects inward and the outer peripheral end of the base portion (21a) deflects forward. Therefore, the brake fluid in the reservoir flows into the first hydraulic chamber (6) through the gaps among the second and first seal portions (21f), (21e) and the wall surface of the recessed portion (20) to maintain fluid-feeding performance.
    Type: Application
    Filed: October 30, 2007
    Publication date: March 18, 2010
    Inventors: Tomohiro Aoki, Masaki Shiwa
  • Patent number: 6499841
    Abstract: A cleaning apparatus and method for removing a recording ink from a surface of a recording material conveying belt of a recording apparatus. The method includes the steps of contacting a blade member to a surface of the recording material conveying belt and contacting an ink absorber member to a surface of the recording material conveying belt, thus removing from the belt surface an improper discharge of recording ink.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: December 31, 2002
    Assignee: Canon Kabushiki Kaisha
    Inventors: Takashi Uchida, Tomohiro Aoki, Tohru Kobayashi, Masatoshi Ikkatai, Yasushi Murayama, Tatsuo Mitomi, Masaharu Nemura, Yasuyuki Takanaka
  • Patent number: 6406118
    Abstract: An ink jet recording apparatus for recording an image by discharging ink from an ink jet recording head to a recording medium at a recording position, the apparatus being capable of recording the image on different recording media having different absorptivities. The apparatus conveys the recording medium along a conveyance route from the recording position, and heats the recording medium at a predetermined position in the conveyance route of the recording medium. In a first operational mode, an operative condition corresponds to a recording medium with a first absorptivity. In a second operational mode, a non-operative condition corresponds to a recording medium with a second absorptivity higher than the first absorptivity. In the invention, the ink jet recording apparatus enters the first operational mode after an electrical power is applied thereto.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: June 18, 2002
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tomohiro Aoki, Yasushi Murayama, Takashi Uchida, Tatsuo Mitomi, Masaharu Nemura
  • Patent number: 6398358
    Abstract: An ink jet textile printing method forms an image on cloths in an image forming operation by repeating a step of applying ink on the cloths from an ink discharge port of a recording head, the recording head relatively main-scanning to form the image in a main scan direction, and a step of relatively conveying the cloths in a sub-scan direction. The method includes the steps of forming the image on the cloths by applying ink on the cloths from the recording head based on image data. The method further includes the step of temporarily stopping the image forming operation in accordance with an indication to effect a temporary halt of the image forming operation. When the temporary halt is indicated while the recording head performs a main scan in the image forming operation, the image forming operation by the main scan is completed, and then the temporary halt of the image forming operation is effected by moving the recording head to a standby position.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: June 4, 2002
    Assignee: Canon Kabushiki Kaisha
    Inventors: Hiroyuki Miyake, Tomohiro Aoki, Kazuyoshi Takahashi, Akio Suzuki, Mitsuru Kurata, Tokihide Ebata, Yoshihiro Takada, Kunihiko Matsuzawa, Hideyuki Tanaami, Yutaka Udagawa, Masatoshi Ikkatai, Keiju Kuboki, Yasushi Miura, Masahiro Nishio, Yasuyuki Takanaka, Eiichi Takagi, Yoshio Komaki, Nobuhiko Ogata