Patents by Inventor Tomohiro Aoki

Tomohiro Aoki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250058373
    Abstract: There is provided a binder for molding a casting mold, which contains water glass and aluminum silicate obtained by carrying out dissolution in the water glass, where the binder for molding a casting mold contains 2 to 15 parts by mass of the aluminum silicate with respect to 100 parts by mass of a solid content of the water glass.
    Type: Application
    Filed: July 26, 2024
    Publication date: February 20, 2025
    Applicant: SINTOKOGIO, LTD.
    Inventors: Kazuyuki NISHIKAWA, Yusuke Kato, Tomohiro Aoki, Toshihiko Zenpo, Tetsuji Matsui
  • Publication number: 20240402183
    Abstract: Spatial analysis methods based on nearest neighbor analysis are provided of specific regions of tissue to describe cancer states and develop biomarkers to predict outcomes. In various embodiments, the spatial analysis methods involve an interaction radius to computationally isolate local interactions and prevent the data from being influenced by cells that are very far away. Thereby, spatial analysis of cancer tissue can be quickly and consistently performed in an automated fashion to focus on tumor-immune cell biology, which occurs at a localized level.
    Type: Application
    Filed: May 31, 2024
    Publication date: December 5, 2024
    Applicants: CEDARS-SINAI MEDICAL CENTER, BC CANCER, part of the Provincial Health Services Authority
    Inventors: Alexander Xu, Akil Merchant, Anthony Colombo, Tomohiro Aoki, Aixiang Jiang, Christian Steidl
  • Patent number: 12157162
    Abstract: The additive composition of the present invention is one blended in a sand composition which is subjected to foaming to mold a sand mold, and includes (A) an alkylsulfonate metal salt having an alkyl group with 9 to 22 carbon atoms. The additive composition may further include at least one component selected from a group consisting of (B) an alkylsulfate metal salt, (C) a polyoxyalkylene alkyl ether sulfate metal salt, and (D) an alkylbenzene sulfonate metal salt.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: December 3, 2024
    Assignees: TAKEMOTO YUSHI KABUSHIKI KAISHA, SINTOKOGIO, LTD.
    Inventors: Yusuke Kato, Tomohiro Aoki, Shumma Sato
  • Publication number: 20240042513
    Abstract: A sand mold-forming additive capable of making a sand mold-forming composition having excellent forming property and a sand mold having excellent moisture resistance is provided. The sand mold-forming additive contains 0.01-2.00 parts by weight of an inorganic alkali metal compound (B) per 100 parts by weight of anionic surfactant (A). The inorganic alkali metal compound (B) is at least one selected from sodium chloride and sodium sulfate. The ionic surfactant (A) is preferably at least one selected from alkyl sulfonic acid metal salts (A1), alkyl sulfuric acid metal salts (A2), and polyoxyalkylene alkyl ether sulfuric acid ester metal salts (A3).
    Type: Application
    Filed: February 9, 2022
    Publication date: February 8, 2024
    Applicants: SINTOKOGIO, LTD., TAKEMOTO YUSHI KABUSHIKI KAISHA
    Inventors: Yusuke KATO, Toshihiko ZENPO, Tomohiro AOKI, Shumma SATO
  • Patent number: 11845694
    Abstract: The invention relates to a composition for forming a casting mold, the composition containing heat-resistant inorganic particles; a waterglass-based binder; a surfactant; a silicon-containing compound; activated carbon powder and grain; and water; and the silicon-containing compound contains at least one of metal silicon and ferrosilicon.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: December 19, 2023
    Assignee: SINTOKOGIO, LTD.
    Inventors: Kazuyuki Nishikawa, Masanori Tomioka, Yusuke Kato, Tetsuji Matsui, Tomohiro Aoki
  • Patent number: 11794380
    Abstract: The present invention includes: an injection container unit; a lid member; and an ejection air supply section configured to press a foamed mixed material in the injection container unit with compressed air and thereby eject the foamed mixed material through an ejection port, the lid member being provided with a sealing body configured to deform when a fluid is injected and thereby make close contact with the inner circumferential surface of the injection container unit during the pressing.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: October 24, 2023
    Assignee: SINTOKOGIO, LTD.
    Inventors: Takayuki Komiyama, Tomohiro Aoki
  • Patent number: 11554411
    Abstract: A casting mold making apparatus and a method employing a tank with a pour hole formed at a bottom wall of the tank and an opening section open toward the opposite side to a bottom wall side. A first process of the method includes stirring component materials inside the tank with a stirring impeller so as to make a foam mixture while an opening section side of the tank is closed and the pour hole is closed. The second process is performed after the first process and includes opening the pour hole, pressing the tank against a mold such that a fill hole formed so as to pass into the mold is disposed adjacent to the pour hole, and supplying compressed air into the tank while stirring the foam mixture inside the tank with the stirring impeller so as to fill the foam mixture into a cavity of the mold.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: January 17, 2023
    Assignee: Sintokogio, Ltd.
    Inventors: Yusuke Kato, Tomohiro Aoki
  • Publication number: 20220371080
    Abstract: The additive composition of the present invention is one blended in a sand composition which is subjected to foaming to mold a sand mold, and includes (A) an alkylsulfonate metal salt having an alkyl group with 9 to 22 carbon atoms. The additive composition may further include at least one component selected from a group consisting of (B) an alkylsulfate metal salt, (C) a polyoxyalkylene alkyl ether sulfate metal salt, and (D) an alkylbenzene sulfonate metal salt.
    Type: Application
    Filed: June 8, 2020
    Publication date: November 24, 2022
    Applicants: TAKEMOTO YUSHI KABUSHIKI KAISHA, SINTOKOGIO, LTD.
    Inventors: Yusuke KATO, Tomohiro AOKI, Shumma SATO
  • Patent number: 11504886
    Abstract: The present invention includes: a connector unit configured to disconnectably connect an injection container unit and a lid member; and a vertically driving mechanism configured to cause the injection container unit and the lid member to move up and down together when the injection container unit and the lid member are connected together and to cause the lid member to move up and down when the injection container unit and the lid member are not connected together.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: November 22, 2022
    Assignee: SINTOKOGIO, LTD.
    Inventors: Takanobu Tozaki, Takayuki Komiyama, Tomohiro Aoki
  • Publication number: 20220226512
    Abstract: Composite particles, each of which is obtained by forming, on the surface of a gadolinium oxide-containing particle, a cover film that contains a polymer obtained by polymerizing a monomer component containing a monomer having an ethylenically unsaturated bond; a macrophage imaging agent which contains the composite particles; and a method for producing composite particles, wherein a monomer component containing a monomer having an ethylenically unsaturated bond and gadolinium oxide-containing particles are mixed with each other, and after emulsifying the thus-obtained monomer component-containing mixture in water in the presence of a surfactant and a polymerization initiator in water, the monomer component is polymerized, thereby forming cover films on the surfaces of the gadolinium oxide-containing particles.
    Type: Application
    Filed: May 27, 2020
    Publication date: July 21, 2022
    Applicants: KYOTO UNIVERSITY, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, JSR CORPORATION
    Inventors: Teruyuki KONDO, Yu KIMURA, Aoi SON, Tetsuya MATSUDA, Hirohiko IMAI, Hirokazu KOSEKI, Tomohiro AOKI, Katsuyuki TAKASE, Masaaki MIYAJI, Koji TAMORI, Takeaki MASUDA, Hirokazu KAI
  • Publication number: 20220194855
    Abstract: The invention relates to a composition for forming a casting mold, the composition containing heat-resistant inorganic particles; a waterglass-based binder; a surfactant; a silicon-containing compound; activated carbon powder and grain; and water; and the silicon-containing compound contains at least one of metal silicon and ferrosilicon.
    Type: Application
    Filed: March 4, 2020
    Publication date: June 23, 2022
    Applicant: SINTOKOGIO, LTD.
    Inventors: Kazuyuki NISHIKAWA, Masanori TOMIOKA, Yusuke KATO, Tetsuji MATSUI, Tomohiro AOKI
  • Publication number: 20210291409
    Abstract: The present invention includes: an injection container unit; a lid member; and an ejection air supply section configured to press a foamed mixed material in the injection container unit with compressed air and thereby eject the foamed mixed material through an ejection port, the lid member being provided with a sealing body configured to deform when a fluid is injected and thereby make close contact with the inner circumferential surface of the injection container unit during the pressing.
    Type: Application
    Filed: February 10, 2021
    Publication date: September 23, 2021
    Applicant: SINTOKOGIO, LTD.
    Inventors: Takayuki KOMIYAMA, Tomohiro AOKI
  • Publication number: 20210291258
    Abstract: A cycle is repeatedly carried out, the cycle including: a material feeding step of feeding a material whose amount is larger than an amount that is needed to form a single mold; a mixing step; an ejection step; and a measurement step of measuring, once before or after the ejection step, an amount of foamed mixed sand contained in a mixing tank. The material at least partially is not fed in the material feeding step in the cycle in which the amount of the foamed mixed sand is not less than a first threshold.
    Type: Application
    Filed: January 7, 2021
    Publication date: September 23, 2021
    Applicant: SINTOKOGIO, LTD.
    Inventors: Tomohiro AOKI, Takayuki KOMIYAMA
  • Publication number: 20210291410
    Abstract: The present invention includes: a connector unit configured to disconnectably connect an injection container unit and a lid member; and a vertically driving mechanism configured to cause the injection container unit and the lid member to move up and down together when the injection container unit and the lid member are connected together and to cause the lid member to move up and down when the injection container unit and the lid member are not connected together.
    Type: Application
    Filed: February 10, 2021
    Publication date: September 23, 2021
    Applicant: SINTOKOGIO, LTD.
    Inventors: Takanobu TOZAKI, Takayuki KOMIYAMA, Tomohiro AOKI
  • Publication number: 20210276076
    Abstract: A casting mold making apparatus and a method employing a tank with a pour hole formed at a bottom wall of the tank and an opening section open toward the opposite side to a bottom wall side. A first process of the method includes stirring component materials inside the tank with a stirring impeller so as to make a foam mixture while an opening section side of the tank is closed and the pour hole is closed. The second process is performed after the first process and includes opening the pour hole, pressing the tank against a mold such that a fill hole formed so as to pass into the mold is disposed adjacent to the pour hole, and supplying compressed air into the tank while stirring the foam mixture inside the tank with the stirring impeller so as to fill the foam mixture into a cavity of the mold.
    Type: Application
    Filed: March 5, 2018
    Publication date: September 9, 2021
    Inventors: Yusuke Kato, Tomohiro Aoki
  • Patent number: 11110510
    Abstract: An expandable aggregate mixture for a mold, which contains an aggregate, a water-soluble binder, a water-soluble foaming agent, water, and spherical metal oxide particles.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: September 7, 2021
    Assignee: Sintokogio, Ltd.
    Inventor: Tomohiro Aoki
  • Publication number: 20210170476
    Abstract: An expandable aggregate mixture for a mold, which contains an aggregate, a water-soluble binder, a water-soluble foaming agent, water, and spherical metal oxide particles.
    Type: Application
    Filed: October 16, 2018
    Publication date: June 10, 2021
    Inventor: Tomohiro Aoki
  • Publication number: 20210113529
    Abstract: Provided is a pharmaceutical for preventing or treating an ophthalmic disease associated with intraocular neovascularization and/or increased intraocular vascular permeability. The inventors of the present invention have made investigations on a pharmaceutical for preventing or treating an ophthalmic disease associated with intraocular neovascularization and/or increased intraocular vascular permeability, and have confirmed that a selective S1P receptor agonist having agonist activity at an S1P1 receptor has an intraocular neovascularization-reducing action and an intraocular vascular permeability-reducing action, thus completing the present invention.
    Type: Application
    Filed: February 1, 2019
    Publication date: April 22, 2021
    Applicants: KYOTO UNIVERSITY, Astellas Pharma Inc.
    Inventors: Hideaki HARA, Shuh NARUMIYA, Tomohiro AOKI, Ichiro ARAMORI, Rie YAMAMOTO
  • Publication number: 20210001392
    Abstract: An aggregate mixture for a mold, the aggregate mixture including an aggregate, a water-soluble binder, a water-soluble foaming agent, an aqueous mold release agent, and water.
    Type: Application
    Filed: March 20, 2019
    Publication date: January 7, 2021
    Inventors: Tomohiro Aoki, Yusuke Kato, Hiroyuki Matsubara
  • Patent number: 10668524
    Abstract: To provide a binder composition for molding, by which a mold made of aggregate has an excellent resistance to moisture. The binder composition for molding contains a water-soluble binder and at least one kind of lithium salt that is selected from a group of lithium silicate, lithium oxide, lithium hydroxide, lithium carbonate, lithium bromide, lithium chloride, lithium nitrate, and lithium nitrite.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: June 2, 2020
    Assignee: Sintokogio, Ltd.
    Inventors: Tomohiro Aoki, Yusuke Kato