Abstract: A multilayer resin substrate includes a base material including stacked resin layers including an opening resin layer, a conductor pattern, and an interlayer connection conductor. A concave portion is provided in the base material. The opening resin layer is closer to a first main surface than other resin layers. The concave portion includes a first opening portion provided by a cutting process from one surface of the opening resin layer, and another resin layer. The interlayer connection conductor is provided by filling a conductor in a second opening portion provided by a cutting process from an opposite surface of the opening resin layer. The end portion of the one surface of the first opening portion is not in contact with the conductor pattern.

Abstract: Compounds or salts thereof represented by formula (I): wherein X indicates a leaving group, Y indicates an affinity peptide having a binding region in a CH2 domain in an immunoglobulin unit comprising two heavy chains and two light chains, M indicates a trivalent group linking the carbon atom in C?O adjacent to M and the carbon atom in C?W via a main chain portion consisting of 3 to 5 carbon atoms, O indicates an oxygen atom, S indicates a sulfur atom, W indicates an oxygen atom or a sulfur atom, N3 indicates an azide group, La indicates a bond or a divalent group, and Lb indicates a bond or a divalent group; and antibodies or salts thereof which can be prepared using such a compound or salt thereof, are useful for controlling the bonding ratio of an antibody and a modifying group within a desired range.

Abstract: A battery state estimation device includes: a first state of charge (SOC) calculator that calculates a first SOC using a first method that uses the battery model parameter of a battery; a second SOC calculator that calculates a second SOC using a second method different from the first method; an alternating-current (AC) impedance measurement unit that measures the AC impedance of the battery when the error between the first SOC and the second SOC is greater than a predetermined threshold; and a battery model parameter calculator that calculates a battery model parameter using the measured AC impedance. The first SOC calculator recalculates the first SOC using the battery model parameter calculated.

Abstract: A storage system comprises nodes and drives, and includes at least one mounting area to install the drives. A node manages a parity group constituted of the plurality of drives; generates, in a case where a target drive that is installed in a first mounting area and that belongs to a first parity group is to be moved from the first mounting area to a second mounting area, difference information regarding a storage area where data was written into the target drive during a period in which the target drive is moved from the first mounting area to the second mounting area; and restore data written into the storage area by using data stored in other drives than the target drive that belongs to the first parity group based on the difference information, and write the data into the target drive that has been moved to the second mounting area.

Abstract: Compounds and salts thereof represented by the following formula (I): wherein X indicates a leaving group, Y indicates an affinity peptide having a binding region to a CH2 domain in an immunoglobulin unit containing two heavy chains and two light chains, O indicates an oxygen atom, S indicates a sulfur atom, W indicates an oxygen atom or a sulfur atom, La indicates a first linker, Lb indicates a second linker, and the total number of atoms constituting a main chain in the first linker and atoms constituting a main chain in the second linker are 5 to 7, facilitate regioselective modification of an antibody with a functional substance and control of the bonding ratio of the antibody to the functional substance within a desired range.

Abstract: A desired antibody or antibody composition may be obtained by modifying a thiol group chemically introduced to an antibody to obtain an antibody composition comprising (A) an antibody intermediate or a salt thereof having a bioorthogonal functional group which may be protected, which is represented by the following formula (A): AbS-L-R]n??(A) wherein Ab is a certain antibody, S is a sulfur atom, L is a divalent group, R is a bioorthogonal functional group which may be protected, and n is an integer from 1 to 8, and (B) a thiol group-introduced antibody or a salt thereof, which is represented by the following formula (B): AbSH]n??(B) wherein Ab and n are the same as formulae (A), and SH is a thiol group; and the like.

Abstract: A work machine comprises a main body, a cab riser, and a shaft. The cab riser includes a cab and a frame, the cab being uprightly positioned on the work machine in a first position, and being tilted forward in a second position, and the frame comprising a first plate to contact a second plate provided on the main body in the first position. The cab riser is rotatable about the shaft in clockwise and counterclockwise directions to and from the first position and the second position. The first plate and the second plate can be clamped together by a clamping assembly in the first position, the clamping assembly including one or more clamps to clamp the first plate and the second plate, and the clamping assembly is mounted on the main body.

Abstract: Compounds having an affinity substance to an antibody, a cleavable portion, and a reactive group, represented by the following Formula (I): A-L-B-R??(I) wherein A is the affinity substance an antibody, L is a cleavable linker which is a divalent group comprising the cleavable portion, B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group, and R is the reactive group to the antibody, in which the affinity substance to an antibody is a certain peptide, or a salt thereof are useful for the modification of an antibody, particularly the regioselective modification of an antibody.

Abstract: Compounds having an affinity substance to an antibody and a bioorthogonal functional group, represented by the following Formula (I): A-L-E-B??(I) wherein A is an affinity substance to an antibody, L is a divalent group comprising a leaving group, E is a divalent group comprising an electrophilic group (i) coupled with the leaving group and (ii) having ability to react with a nucleophilic group in the antibody, B is a bioorthogonal functional group, and the leaving group has ability to be cleaved and eliminated from E by a reaction between the nucleophilic group and the electrophilic group, or a salt thereof, and the like are useful for labelling antibodies.

Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R??(I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the present specification, or a salt thereof are useful for the prophylaxis or treatment of diabetes and obesity, and diseases related thereto.

Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

Abstract: Beads containing a polymer containing uronic acid units having mercapto groups, in which the mercapto groups partly or entirely form disulfide bonds, are useful for encapsulating cells and microorganisms.

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the present specification, or a salt thereof are useful for the prophylaxis or treatment of diabetes and obesity, and diseases related thereto.

Abstract: Wind power generating equipment includes: a generator that is driven by a blade which rotates by receiving the wind; a power converter that converts an electric output of the generator such that the output is interconnected with an electric power system; a power converter controller that controls the power converter; and a wind turbine control board that transmits, to the power converter controller, an active power command value that is used as a command value of the electric output which is transmitted from the power converter. The power converter controller controls the output of the power converter in response to an active power command value, depending on a reduction amount of a system voltage when instantaneous reduction occurs in the system voltage interconnected with the wind power generating equipment. This permits stable operation of the wind power generating system when instantaneous voltage reduction occurs such as during a system abnormality.

Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

Abstract: This aims to provide an analyzing tool including a substrate, a first electrode formed on the substrate and having an action pole, a second electrode formed on the substrate and having an opposed pole, and a first regulating element for regulating such a contact area in the action pole as to contact a specimen. The analyzing tool further comprises second regulating elements for regulating the effective area for electron transfers in at least one of the action pole and the opposed pole.

Abstract: Based on an output signal outputted from an input device, a plurality of selection objects having at least a part thereof displayed on a display area of a display device are moved relative to the display area. Among the moved plurality of selection objects, when an end-located selection object reaches a predetermined position of the display area, at least one of the plurality of selection objects displayed on the display area are transformed and displayed.

Abstract: A bundling tool includes first and second bundling members in plate like shapes. The first and second bundling members respectively include central parts that cover wires, first locking parts that are bendable and extend from first sides of the central parts, and second locking parts that are bendable and extend from second sides of the central parts. When the first and second bundling members clamp the wires therebetween and are to be crimped, the first and second locking parts of the first bundling member are each folded down to abut on an outer surface of the second bundling member at an end part of the locking part, and the first and second locking parts of the second bundling member are each folded down to abut on an outer surface of the first bundling member at an end part of the locking part, thereby crimping the wires.

Abstract: Provided are application execution means for executing one or more application programs, and metadata accumulation and storage means for accumulating and storing, into a metadata storage section, metadata corresponding to the one or more application programs when the application programs have been executed or become executable. The application execution means executes the one or more application programs which use the metadata stored in the metadata storage section.