Abstract: The present invention provides a method for inexpensively and efficiently synthesizing polypeptide compounds comprising various amino acids. The method involves (i) inducing an amide formation reaction between the carboxyl group on the right side in the formula of the amino acid or peptide compound represented by formula (R1) and the amino group on the left side in the formula of the amino acid ester or peptide ester compound represented by formula (R2) in the presence of an aluminum compound represented by formula (A) to obtain a peptide compound represented by formula (P1) (the definitions of the reference signs in the formula are as presented in the description).

Abstract: A network system (hybrid network (10)) includes a fixed representative node (101, 102), includes a plurality of terminal-accommodating networks (mobile networks (20, 21)) that transfers communication data between terminals (mobile terminals (401, 402)), an adjacent mobile node enabled to communicate with the fixed representative node (101, 102), and mobile nodes (201 to 204) different from the adjacent mobile node, and includes an ad hoc network 31 whose network topology dynamically changes depending on a locational relationship between the mobile nodes. When receiving communication data from the terminal (mobile terminal (401)) to the terminal (mobile terminal (402)), the fixed representative node (101) transfers the communication data to the mobile node (201) that is the adjacent mobile node. In the ad hoc network 31, the communication data is transferred to the mobile node (204), transmitted to the fixed representative node (102), and further transmitted to the terminal (mobile terminal (402)).

Abstract: The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubral pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: A monitoring device (120) is provided at a building (100) in which an elevator (110) is provided and communicates with a center via an IP network (401). The monitoring device (120) includes a communication unit (143) and a selecting unit (133). The communication unit (143) can perform wireless communication in a plurality of communication modes. The selecting unit (133) selects a connection mode on the basis of a first evaluation value and a second evaluation value. The communication unit (143) transmits voice data and state data indicating a state of the elevator (110) to the center in the connection mode.

Abstract: The present invention provides a novel means capable of producing an amide compound by highly stereoselectively and/or highly efficiently causing an amide reaction in various substrates having a carboxyl group and an amino group. This reaction agent causes an amide reaction between a carboxyl group and an amino group, and contains a silane compound represented by general formula (C1) or the like.

Abstract: The present disclosure provides an immunochromatographic test piece which prevents a non-specific reaction by efficiently and continuously contacting and neutralizing a developing solution containing nitrous acid with a neutralizing reagent in an immunochromatography method of extracting and measuring a sugar chain antigen by nitrous acid extraction on the immunochromatographic test piece. The present disclosure also provides an immunochromatographic test piece for extracting and measuring a sugar chain antigen in a specimen, which comprises: a sample pad; a label region; a detection region on which the antibody against the sugar chain antigen is immobilized; a region impregnated with a neutralizing reagent upstream of the label region, and a region impregnated with a solid acid reagent or a region impregnated with nitrite, upstream of the region impregnated with the neutralizing reagent.

Abstract: The present invention provides, as a novel compound that can be utilized for efficient synthesis or the like of a polypeptide comprising various amino acids, a silane-containing condensed cyclic dipeptide compound represented by formula (A).

Abstract: It is an object of the present invention to provide a method or an immunochromatographic test piece, which controls a speed or a direction of development of a specimen on the immunochromatographic test piece, so that a treatment with an acid reagent, nitrite, and a neutralizing reagent is properly controlled. The present invention provides an immunochromatographic test piece for extracting and measuring a sugar chain antigen in a specimen, the immunochromatographic test piece having a neutralizing region impregnated with a neutralizing reagent upstream of a label region, and further having a solid acid reagent or nitrite region impregnated with a solid acid reagent, or with nitrite, upstream of the neutralizing region, wherein a resin-made sheet is sandwiched between the solid acid reagent or nitrite region the neutralizing region so as to suppress the movement of a reagent or the movement of a specimen solution between the regions.

Abstract: A self-retaining device (medicine administration device) includes a main body and a main-body-side attachment sheet. The main-body-side attachment sheet has a first section that fixes a back surface of the main body, a second section that is adjacent to the first section and allows the main body to rise, and a periphery section that projects outward of the first section and the second section and is configured to be attached to a body surface. In the lateral extension parts of the periphery section, a width of a boundary adjacent part overlapping an extension line of a boundary between the first section and the second section is wider than a width of a second section adjacent part positioned on a side closer to the second section than the extension line.

Abstract: An elevator preventive maintenance system capable of helping, when an abnormality of an elevator is predicted to occur, a concerned person needing no countermeasure information to grasp information quickly and easily, and helping a concerned person needing countermeasure information to react to the abnormality quickly and precisely. The system includes: a prediction section configured to predict an abnormality of an elevator to occur, based on abnormality prediction information; a storage section configured to pre-store concerned person information relating to the elevator; a communication section configured to transmit abnormality occurrence prediction information to concerned person in the case the abnormality is predicted to occur.

Abstract: [Problem] To provide a novel means capable of generating highly stereoselective and/or highly efficient amidation reactions in a variety of substrates having a carboxyl group and an amino group, and capable of producing amide compounds. [Solution] A reaction agent for amide reactions between carboxyl groups and amino groups and including a silane compound indicated by general formula (A) and/or general formula (B). (In general formulas (A) and (B), each substituent represents the definition described in the Claims.

Abstract: Provided is a novel method whereby an amide compound can be produced by highly stereoselectively and efficiently performing amidation between a plurality of amino acids and/or peptides. A compound of general formula (3) is synthesized by forming an amide bond between the carboxyl group on the right side of general formula (1) in a compound represented thereby and the amino group on the left side of general formula (2) in a compound represented thereby, in the presence of a Lewis acid catalyst and a silylating agent [in formulae (1), (2) and (3), each symbol has the same meaning as defined in claims].

Abstract: Provided is a novel method for producing amide compounds at high stereochemical selectivities. The method according to the present invention for producing amide compounds is provided with an amidation step for reacting, in the presence of a catalyst comprising a metal compound, an amino compound with an aminoester compound represented by general formula (1) to amidate the ester group in the aminoester compound.

Abstract: A retrieval system includes a first storage unit (211), a second storage unit (212), a selection unit (216), an extraction unit (217), and a calculation unit (218). The second storage unit (212) stores a plurality of signal tables. The selection unit (216) selects a first use table from the plurality of signal tables. The extraction unit (217) extracts a value of each signal registered in the first use table from the first signal group and the second signal group. The calculation unit (218) calculates a similarity level between the first signal group and the second signal group.

Abstract: Methods of agglutinating and separating erythrocytes, by which erythrocytes can be instantaneously agglutinated into a sufficient size in a blood sample and completely separated from the blood sample; and a hemagglutination reagent are provided. The method of agglutinating erythrocytes according to the present invention includes adding a solution containing a cholic acid-based surfactant and an acid to a blood sample. The method of separating erythrocytes according to the present invention includes separating the erythrocytes agglutinated by the above-described method of the present invention. The hemagglutination reagent according to the present invention contains a cholic acid-based surfactant and an acid.

Abstract: A self-retaining device (medicine administration device) includes a main body and a main-body-side attachment sheet. The main-body-side attachment sheet has a first section that fixes a back surface of the main body, a second section that is adjacent to the first section and allows the main body to rise, and a periphery section that projects outward of the first section and the second section and is configured to be attached to a body surface. In the lateral extension parts of the periphery section, a width of a boundary adjacent part overlapping an extension line of a boundary between the first section and the second section is wider than a width of a second section adjacent part positioned on a side closer to the second section than the extension line.

Abstract: It is intended to provide a method and an immunochromatographic device, which are capable of measurement with sufficient sensitivity by performing a nitrous acid extraction treatment over a sufficient period of time in an immunochromatography method of extracting and measuring a sugar chain antigen by nitrous acid extraction on an immunochromatographic test piece.

Abstract: A maintenance device (18) includes, for example, a clock (20), a clock (21), a selection unit (23), and a recording unit (25). The clock (20) outputs time information. The clock (21) outputs time information. The selection unit (23) selects at least one of the clock (20) or the clock (21) as a clock to be used. The recording unit (25) records elevator information by adding time information from the selected clock to the elevator information. The selection unit (23) selects the clock to be used according to the content of the elevator information to be recorded by the recording unit (25).

Abstract: Provided is a novel method whereby an amide compound can be produced by highly stereoselectively and efficiently performing amidation between a plurality of amino acids and/or peptides.