Patents by Inventor Tomohiro Ide
Tomohiro Ide has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11873761Abstract: A liquid fuel injector includes a cylindrical primary fuel injecting body having a central axis; an annular shroud concentrically placed radially outside; and an annular secondary fuel injecting body placed concentrically with the primary fuel injecting body and the shroud between the primary fuel injecting body and the shroud. A plurality of inner swirlers placed at equal intervals in a circumferential direction are provided in an annular inner air passage formed between the primary fuel injecting body and the secondary fuel injecting body, and a plurality of outer swirlers placed at equal intervals in the circumferential direction are provided in an annular outer air passage formed between the secondary fuel injecting body and the shroud. The primary fuel injecting body is formed as a pressure spray-type injector, and the secondary fuel injecting body and the inner and outer air passages cooperatively constitute an airblast-type injector.Type: GrantFiled: December 29, 2021Date of Patent: January 16, 2024Assignee: IHI CORPORATIONInventors: Takehiko Watase, Kouta Kanai, Nagayoshi Hiromitsu, Junya Kowa, Shinichiro Ishizaki, Katsuyoshi Takahashi, Tomohiro Ide, Shonosuke Kita, Mitsunori Itoh, Yuki Iwaki, Narumi Ando, Hitoshi Hattori, Kazuo Yonekura
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Publication number: 20220120222Abstract: A liquid fuel injector includes a cylindrical primary fuel injecting body having a central axis; an annular shroud concentrically placed radially outside; and an annular secondary fuel injecting body placed concentrically with the primary fuel injecting body and the shroud between the primary fuel injecting body and the shroud. A plurality of inner swirlers placed at equal intervals in a circumferential direction are provided in an annular inner air passage formed between the primary fuel injecting body and the secondary fuel injecting body, and a plurality of outer swirlers placed at equal intervals in the circumferential direction are provided in an annular outer air passage formed between the secondary fuel injecting body and the shroud. The primary fuel injecting body is formed as a pressure spray-type injector, and the secondary fuel injecting body and the inner and outer air passages cooperatively constitute an airblast-type injector.Type: ApplicationFiled: December 29, 2021Publication date: April 21, 2022Applicant: IHI CORPORATIONInventors: Takehiko WATASE, Kouta KANAI, Nagayoshi HIROMITSU, Junya KOWA, Shinichiro ISHIZAKI, Katsuyoshi TAKAHASHI, Tomohiro IDE, Shonosuke KITA, Mitsunori ITOH, Yuki IWAKI, Narumi ANDO, Hitoshi HATTORI, Kazuo YONEKURA
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Patent number: 9863955Abstract: A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active ingredient, a compound inhibiting an interaction between prohibitin and AMPK, and a prohibitin-AMPK complex are also provided.Type: GrantFiled: May 16, 2013Date of Patent: January 9, 2018Assignee: KYORIN PHARMACEUTICAL CO., LTD.Inventors: Tomohiro Ide, Naoki Kobayashi, Yunike Akasaka, Takashi Komine, Koji Murakami
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Publication number: 20150126387Abstract: A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active ingredient, a compound inhibiting an interaction between prohibitin and AMPK, and a prohibitin-AMPK complex are also provided.Type: ApplicationFiled: May 16, 2013Publication date: May 7, 2015Applicant: Kyorin Pharmaceutical Co., Ltd.Inventors: Tomohiro Ide, Naoki Kobayashi, Yunike Akasaka, Takashi Komine, Koji Murakami
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Publication number: 20130143913Abstract: An object of the present invention is to provide an agent for prevention or treatment of a fatty liver disease, preferably NAFLD, more preferably NASH. The present invention provides an agent for prevention or treatment of a fatty liver disease containing ibudilast as an active agent.Type: ApplicationFiled: August 11, 2011Publication date: June 6, 2013Applicant: KYORIN PHARMACEUTICAL CO., LTD.Inventors: Toshiyuki Matsui, Tomohiro Ide, Masaki Tsunoda, Tomomi Ogata, Minoru Ito
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Patent number: 8173649Abstract: A compound represented by the following formula (1): (wherein the carbon atom denoted by * is in the R-configuration; R1 and R2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylsulfanyl group, a C1-C6 alkylsulfinyl group or a C1-C6 alkylsulfonyl group; and A is a substituted or unsubstituted heteroaryl group), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 21, 2007Date of Patent: May 8, 2012Assignees: Kyorin Pharmaceutical Co., Ltd., Teijin Pharma LimitedInventors: Yasumichi Fukuda, Yoshikazu Asahina, Ayako Nakamura, Kenji Fujita, Tomohiro Ide, Fumiyoshi Kobayashi, Shinji Kobayashi, Kanji Komatsu, Masanori Yamamoto
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Patent number: 8034819Abstract: A compound, or a pharmaceutically acceptable salt thereof, represented by the formula (1), (wherein, the carbon atom marked with an * is in the R-configuration, R1 represents a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1-C6 alkyl group, or a C1-C6 alkoxy group, R2 represents a C3-C6 cycloalkylsulfanyl group, a C3-C6 cycloalkylsulfinyl group, or a C3-C6 cycloalkylsulfonyl group, and A represents a substituted or unsubstituted heteroaryl group).Type: GrantFiled: March 6, 2008Date of Patent: October 11, 2011Assignees: Kyorin Pharmaceutical Co., Ltd., Teijin Pharma LimitedInventors: Yasumichi Fukuda, Yoshikazu Asahina, Masanori Takadoi, Kohei Ohata, Tomohiro Ide, Fumiyoshi Kobayashi, Shinji Kobayashi, Kanji Komatsu, Masanori Yamamoto
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Publication number: 20100099671Abstract: A compound, or a pharmaceutically acceptable salt thereof, represented by the formula (1), (wherein, the carbon atom marked with an * is in the R-configuration, R1 represents a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1-C6 alkyl group, or a C1-C6 alkoxy group, R2 represents a C3-C6 cycloalkylsulfanyl group, a C3-C6 cycloalkylsulfinyl group, or a C3-C6 cycloalkylsulfonyl group, and A represents a substituted or unsubstituted heteroaryl group).Type: ApplicationFiled: March 6, 2008Publication date: April 22, 2010Inventors: Yasumichi Fukuda, Yoshikazu Asahina, Masanori Takadoi, Kohei Ohata, Tomohiro Ide, Fumiyoshi Kobayashi, Shinji Kobayashi, Kanji Komatsu, Masanori Yamamoto
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Publication number: 20100016304Abstract: A compound represented by the following formula (1): (wherein the carbon atom denoted by * is in the R-configuration; R1 and R2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylsulfanyl group, a C1-C6 alkylsulfinyl group or a C1-C6 alkylsulfonyl group; and A is a substituted or unsubstituted heteroaryl group), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 21, 2007Publication date: January 21, 2010Inventors: Yasumichi Fukuda, Yoshikazu Asahina, Ayako Nakamura, Kenji Fujita, Tomohiro Ide, Fumiyoshi Kobayashi, Shinji Kobayashi, Kanji Komatsu, Masanori Yamamoto
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Patent number: 7560569Abstract: Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).Type: GrantFiled: February 17, 2005Date of Patent: July 14, 2009Assignee: Kyorin Pharmaceutical Co., LtdInventors: Yasumichi Fukuda, Yoshikazu Asahina, Satoru Katayama, Taku Shibue, Koji Murakami, Tomohiro Ide
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Patent number: 7514571Abstract: A novel bicyclo derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof, acts as an effective DPP-IV inhibitor: One example is (2S,4S)-1-[[N-(4-methylbicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile).Type: GrantFiled: February 22, 2005Date of Patent: April 7, 2009Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Yasumichi Fukuda, Yoshikazu Asahina, Kazuya Yokota, Koji Murakami, Tomohiro Ide
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Publication number: 20070265320Abstract: Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).Type: ApplicationFiled: February 17, 2005Publication date: November 15, 2007Applicant: KYORIN PHARMACEUTICAL CO., LTDInventors: Yasumichi Fukuda, Yoshikazu Asahina, Satoru Katayama, Taku Shibue, Koji Murakami, Tomohiro Ide
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Publication number: 20070167501Abstract: A novel bicyclo derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof, acts as an effective DPP-IV inhibitor: One example is (2S,4S)-1-[[N-(4-methylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile).Type: ApplicationFiled: February 22, 2005Publication date: July 19, 2007Inventors: Yasumichi Fukuda, Yoshikazu Asahina, Kazuya Yokota, Koji Murakami, Tomohiro Ide
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Patent number: 6762171Abstract: The invention creates a very high-novelty medicinal drug for the carbohydrate and lipid metabolism-related diseases by finding out an inhibitory substance or antagonist against PPAR &agr; and PPAR &ggr;, and relates to an application of fatty acid CoA thioester that was found out as an active inhibitory substance against peroxisome proliferator-activated receptor &agr; and &ggr; (hereinafter referred to as PPARs) to the assay of medicinal drug, and a use of fatty acid CoA thioester for medicinal drug.Type: GrantFiled: May 30, 2002Date of Patent: July 13, 2004Assignee: Kyorin Pharmaceutical Co, Ltd.Inventors: Koji Murakami, Tomohiro Ide, Toshiro Mochizuki, Takashi Kadowaki
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Patent number: 6506797Abstract: The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor &agr; (PPAR&agr;), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride). It relates to a substituted phenylpropanoic acid derivatives represented by a general formula (1), their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.Type: GrantFiled: December 10, 2001Date of Patent: January 14, 2003Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Masahiro Nomura, Yukie Takahashi, Takahiro Tanase, Hiroyuki Miyachi, Masaki Tsunoda, Tomohiro Ide, Koji Murakami