Abstract: The present invention relates to a therapeutic agent represented by the General formula (I), or a pharmacologically acceptable salt thereof, or a solvate of the compound or the salt thereof: The therapeutic agent comprises a substance having the activity of inhibiting kinase activity of fibroblast growth factor receptor 2 (“FGFR2”). The therapeutic agent can be used for treating undifferentiated gastric cancer, and can also be used to treat organisms comprising a cell overexpressing FGFR2 or a cell expressing mutant FGFR2, or both. The present invention further relates to a pharmaceutical composition comprising an FGFR2 inhibitory and methods of treatment therewith. The present invention also relates to a method for predicting the effect of an FGFR2 inhibitory substance on a patient.

Abstract: A steel plate for line pipes containing, in terms of % by weight, C: 0.02 to 0.06%, Si: 0.5% or less, Mn: 0.8 to 1.6%, P: 0.008% or less, S: 0.0008% or less, Al: 0.08% or less, Nb: 0.005 to 0.035%, Ti: 0.005 to 0.025%, and Ca: 0.0005 to 0.0035%, and optionally contains one or more of Cu: 0.5% or less, Ni: 1% or less, Cr: 0.5% or less, Mo: 0.5% or less and V: 0.1% or less, and has a CP value of 0.95 or less represented by CP=4.46C(%)+2.37Mn(%)/6+{1.18Cr(%)+1.95Mo(%)+1.74V(%)}/5+{1.74Cu(%)+1.7Ni(%)}/15+22.36P(%), and a Ceq value of 0.30 or more represented by Ceq=C(%)+Mn(%)/6+{Cr(%)+Mo(%)+V(%)}/5 +{Cu(%)+Ni(%)}/15.

Abstract: A battery terminal includes a housing, a bus bar, a first connector, a second connector and a current detector. The housing is made by resin. The bus bar is integrally provided with the housing. The first connector is provided on the bus bar and is adapted to be connected with a battery. The current detector is provided on the bus bar. The second connector is provided on the bus bar. The second connector is adapted to be connected with a harness, and is disposed at a position offset from a straight line passing the first connector and the current detector.

Abstract: This invention provides methods and apparatuses which can manufacture Si-containing cold rolled steel sheets exhibiting excellent chemical conversion properties even if a chemical conversion treatment solution is used at a lower temperature while minimally suppressing the generation of sludge as well as reducing running costs. The method includes steps of cold rolling a steel containing 0.5 to 3.0 mass % Si, continuously annealing the cold rolled steel sheet, pickling the surface of the continuously annealed cold rolled steel sheet, and repickling the surface of the pickled steel sheet with a non-oxidative acid. The repickling is performed such that a repickling solution is sampled continuously or periodically, an acid concentration in the sampled solution is measured, and the acid concentration in the repickling solution is regularly controlled within a prescribed concentration range.

Abstract: A rotation angle sensor includes a rotation shaft, a yoke which is made from a magnetic permeable material and includes a first disk portion, a second disk portion and a connection portion magnetically connecting the first disk portion and the second disk portion, the first disk portion and the second disk portion being provided on the rotation shaft in an axial direction of the rotation shaft separately, a first permanent magnet and a second permanent magnet, each having a disk shape which has a uniform plate thickness in a circumferential direction thereof, and which are provided on a first face of the first disk portion and a second face of the second disk portion respectively, the first face being opposed to the second face, a magnetic field detection section which is provided between the first permanent magnet and the second permanent magnet, and generates an output signal in response to an intensity of a magnetic field formed by the first permanent magnet and the second permanent magnet during a rotatio

Abstract: The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.

Abstract: An angle detector includes a rotating member, a housing, a detector and an urging member. The rotating member is rotatable with a shaft inserted therethrough. The housing rotatably supports the rotating member. The detector detects a rotating angle of the rotating member with respect to the housing. The urging member urges the rotating member in a rotating direction of the rotating member. An engagement portion is provided on the housing. An engaged portion is provided on the rotating member. The engaged portion is adapted to be brought into engagement with the engagement portion by urged by the urging member.

Abstract: An antitumor agent for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound or pharmaceutically acceptable salt thereof represented by Formula (II) exhibits an excellent antitumor effect compared to cases where these are individually used, and exhibits antitumor effects against various cancer types: wherein R1 is azetidinyl and the like, R2 to R5 is a hydrogen atom or a halogen atom, R6 is C3-8 cycloalkyl and the like, R7 is a hydrogen atom and the like, and R8 is a halogen atom and the like.

Abstract: A rotation angle sensor includes a rotation shaft, a yoke which is made from a magnetic permeable material and includes a first disk portion, a second disk portion and a connection portion magnetically connecting the first disk portion and the second disk portion, the first disk portion and the second disk portion being provided on the rotation shaft in an axial direction of the rotation shaft separately, a permanent magnet which is provided between the first disk portion and the second disk portion, and has an annular shape, and a magnetic field detection section which generates an output signal in response to an intensity of a magnetic field formed by the permanent magnet during a rotation of the rotation shaft.

Abstract: The invention provides acid addition salts of the compounds represented by formula (1) or (2), or crystals thereof, and processes for preparing the same. The salts or crystals have HGFR inhibitory activity and excellent physical properties (solubility, safety, etc.) and are therefore useful as anti-tumor agents, angiogenesis inhibitors and inhibitors for metastasis for a various types of tumor.

Abstract: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

Abstract: A compound represented by the following formula, or a salt thereof or a hydrate of the foregoing, has excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity, and cancer metastasis inhibitory activity. R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents —CH?, nitrogen or the like.

Abstract: A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents —CH?, nitrogen.

Abstract: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

Abstract: Compounds represented by the following general formula: wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—), Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.), salts thereof or hydrates of the foregoing.

Abstract: The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein. In certain embodiments, the compositions are for systemic (e.g., oral) administration. In certain embodiments, methods for the treatment of various disorders including inflammatory or autoimmune disorders comprise systemically (e.g., orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I).

Abstract: An angle detector includes a rotating member, a housing, a detector and an urging member. The rotating member is rotatable with a shaft inserted therethrough. The housing rotatably supports the rotating member. The detector detects a rotating angle of the rotating member with respect to the housing. The urging member urges the rotating member in a rotating direction of the rotating member. An engagement portion is provided on the housing. An engaged portion is provided on the rotating member. The engaged portion is adapted to be brought into engagement with the engagement portion by urged by the urging member.

Abstract: A steel plate for line pipes containing, in terms of % by weight, C: 0.02 to 0.06%, Si: 0.5% or less, Mn: 0.8 to 1.6%, P: 0.008% or less, S: 0.0008% or less, Al: 0.08% or less, Nb: 0.005 to 0.035%, Ti: 0.005 to 0.025%, and Ca: 0.0005 to 0.0035%, and optionally contains one or more of Cu: 0.5% or less, Ni: 1% or less, Cr: 0.5% or less, Mo: 0.5% or less and V: 0.1% or less, and has a CP value of 0.95 or less represented by CP=4.46C(%)+2.37Mn(%)/6+{1.18Cr(%)+1.95Mo(%)+1.74V(%)}/5+{1.74Cu(%)+1.7Ni(%)}/15+22.36P(%), and a Ceq value of 0.30 or more represented by Ceq=C(%)+Mn(%)/6+{Cr(%)+Mo(%)+V(%)}/5+{Cu(%)+Ni(%)}/15.

Abstract: A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents —CH?, nitrogen or the like.

Abstract: A battery terminal includes a housing, a bus bar, a first connector, a second connector and a current detector. The housing is made by resin. The bus bar is integrally provided with the housing. The first connector is provided on the bus bar and is adapted to be connected with a battery. The current detector is provided on the bus bar. The second connector is provided on the bus bar. The second connector is adapted to be connected with a harness, and is disposed at a position offset from a straight line passing the first connector and the current detector.