Abstract: A method of reducing noise in an output signal of a differential refractive index detection part (RI detection part) of a dual-flow type with an analysis device having the RI detection part includes sending a sample liquid to a sample cell with a sample pump, sending a reference liquid to a reference cell with a reference pump, and detecting a change in direction of travel of light sequentially transmitted through the two cells with a light detector. Before starting RI measurement, a phase difference between the sample pump and the reference pump is adjusted so that a noise that occurs in an output signal of the light detector by propagation of pulsation from the sample pump within the sample cell and a noise that occurs in the output signal of the light detector by propagation of pulsation from the reference pump within the reference cell cancel each other.

Abstract: A method of reducing noise in an output signal of a differential refractive index detection part (RI detection part) of a dual-flow type with an analysis device having the RI detection part includes sending a sample liquid to a sample cell with a sample pump, sending a reference liquid to a reference cell with a reference pump, and detecting a change in direction of travel of light sequentially transmitted through the two cells with a light detector. Before starting RI measurement, a phase difference between the sample pump and the reference pump is adjusted so that a noise that occurs in an output signal of the light detector by propagation of pulsation from the sample pump within the sample cell and a noise that occurs in the output signal of the light detector by propagation of pulsation from the reference pump within the reference cell cancel each other.