Patents by Inventor Tomohisa Takita
Tomohisa Takita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6514946Abstract: 20,23-disubstituted mycaminosyltylonolide derivatives and use of the same in the field of the prophylaxis and treatment of pasteurellosis are disclosed. The di-substituents are peperidino optionally substituted with one or two methyl groups. The derivatives have selective antibacterial activity against Pasteurella.Type: GrantFiled: August 29, 2000Date of Patent: February 4, 2003Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Toshiaki Miyake, Tomohisa Takita, Masa Hamada, Tomio Takeuchi, Sumio Umezawa
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Patent number: 4960910Abstract: The present invention relates to an oxetane derivative represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are each an acyl group and R.sub.3 is a hydrogen atom or a lower alkyl group, which is useful as an intermediate for the preparation of a compound having a (bishydroxymethyl)oxetane structure in its saccharide moiety, for example, oxetanosine, and a process for the preparation of the same.Type: GrantFiled: June 13, 1989Date of Patent: October 2, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kuniki Kato, Tomohisa Takita, Shigeru Nishiyama, Shosuke Yamamura
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Patent number: 4716221Abstract: This invention relates to a novel 4'-demethyl-4-epipodophylltoxin derivative of the formula: ##STR1## (wherein R.sub.1 is a lower alkyl group; X.sub.1 and X.sub.2 are each a hydroxyl group or an amino group substituted by one or two lower alkyls, provided that either one of X.sub.1 and X.sub.2 is an amino group substituted by one or two lower alkyls and the other is a hydroxyl group) and salts thereof.Type: GrantFiled: March 21, 1986Date of Patent: December 29, 1987Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Wataru Tanaka, Tomohisa Takita, Yoshio Nishimura, Hiroshi Yoshikawa
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Patent number: 4547567Abstract: This invention relates to novel 4'-demethyl-4-epipodophyllotoxin derivatives represented by the general formula (I), and salts thereof: ##STR1## wherein R is a lower alkyl group, and X.sub.1 and X.sub.2 are independently a hydroxyl group or an amino group, the one being an amino group and the other being a hydroxyl group. These novel derivatives have a high carcinostatic activity and a relatively high water solubility and hence are expected to be useful as carcinostatics.Type: GrantFiled: July 18, 1984Date of Patent: October 15, 1985Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Wataru Tanaka, Tomohisa Takita, Yoshio Nishimura, Hiroshi Yoshikawa
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Patent number: 4530998Abstract: This invention relates to 2'-deoxy-oxanosine represented by the following formula: ##STR1## and process for the preparation thereof. This new compound exhibits a growth inhibiting action to gram-negative bacteria and has a carcinostatic action.Type: GrantFiled: March 5, 1984Date of Patent: July 23, 1985Assignee: Zaidan Hojin Biseibutsu Kagaku KenkyuKaiInventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka, Tomohisa Takita, Nobuyoshi Shimada, Kuniki Kato
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Patent number: 4495347Abstract: The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.Type: GrantFiled: November 5, 1982Date of Patent: January 22, 1985Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Nobuyoshi Shimada, Hiroshi Naganawa, Tomohisa Takita, Masa Hamada, Tomio Takeuchi
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Patent number: 4394446Abstract: The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral and carcinostatic activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.Type: GrantFiled: November 20, 1981Date of Patent: July 19, 1983Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Nobuyoshi Shimada, Hiroshi Naganawa, Tomohisa Takita, Masa Hamada, Tomio Takeuchi
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Patent number: 4326054Abstract: Novel antibiotics cleomycins represented by the formula ##STR1## wherein R is a terminal amino residue of the cleomycin. These compounds are useful as a chemotherapeutic agent for treating cancer and bacterial infections.Type: GrantFiled: July 9, 1980Date of Patent: April 20, 1982Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomohisa Takita, Akio Fujii, Yasuhiko Muraoka, Mamoru Kunishima
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Patent number: 4267102Abstract: N-methylbleomycins represented by the general formula ##STR1## which are useful as antitumor agents and bactericides; a method of preparing the same; and intermediate products in the preparation thereof.Type: GrantFiled: February 29, 1980Date of Patent: May 12, 1981Assignee: Nippon Kayaku Kabushiki KaishaInventors: Akio Fujii, Takeyo Fukuoka, Yasuhiko Muraoka, Tomohisa Takita, Hamao Umezawa
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Patent number: 4240975Abstract: Bestatin, which is [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, and related compounds which inhibit aminopeptidase B, leucino aminopeptidase and Bleomycin hydrolase, enhance the anti-tumor effect of Bleomycin and exhibit an antifertility effect were synthesized and tested.Type: GrantFiled: September 26, 1979Date of Patent: December 23, 1980Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Takaaki Aoyagi, Tomohisa Takita, Rinzo Nishizawa, Tetsushi Saino
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Patent number: 4238391Abstract: Novel 3-[(S)-1'-phenylethylamino]propylaminobleomycin obtained by reacting a reactive derivative of the carboxyl group of bleomycinic acid with N-[(S)-1'-phenylethyl]-1,3-diaminopropane, a non-toxic salt of said novel bleomycin, and a method for producing the novel bleomycin. Because of much reduction in the side effect causing pulmonary fibrosis, the novel bleomycin is more useful than a commercial bleomycin complex which gives rise to said undesirable side effect.Type: GrantFiled: July 18, 1979Date of Patent: December 9, 1980Assignee: Nippon Kayaku Kabushiki KaishaInventors: Tomohisa Takita, Akio Fujii, Takeyo Fukuoka, Yasuhiko Muraoka, Osamu Yoshioka, Hamao Umezawa
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Patent number: 4195018Abstract: Novel 3-[(S)-1'-phenylethylamino]propylaminobleomycin obtained by reacting a reactive derivative of the carboxyl group of bleomycinic acid with N-[(S)-1'-phenylethyl]-1,3-diaminopropane, a non-toxic salt of said novel bleomycin, and a method for producing the novel bleomycin. Because of much reduction in the side effect causing pulmonary fibrosis, the novel bleomycin is more useful than a commercial bleomycin complex which gives rise to said undesirable side effect.Type: GrantFiled: June 15, 1978Date of Patent: March 25, 1980Assignee: Nippon Kayaku Kabushiki KaishaInventors: Tomohisa Takita, Akio Fujii, Takeyo Fukuoka, Yasuhiko Muraoka, Osamu Yoshioka, Hamao Umezawa
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Patent number: 4189604Abstract: Bestatin, which is [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, and related compounds which inhibit aminopeptidase B, leucino aminopeptidase and Bleomycin hydrolase, enhance the anti-tumor effect of Bleomycin and exhibit an antifertility effect were synthesized and tested.Type: GrantFiled: June 24, 1977Date of Patent: February 19, 1980Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Takaaki Aoyagi, Tomohisa Takita, Rinzo Nishizawa, Tetsushi Saino
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Patent number: 3984390Abstract: By adding a specific amine in culturing under aerobic conditions actinomycetales capable of producing phleomycin group antibiotics, which have been inoculated into a nutrient medium to produce antitumor phleomycin group antibiotics, it is possible to obtain specific phleomycin group antibiotics having a side chain structure corresponding to said amine. The phleomycin group antibiotics thus produced are collected from the culture medium in a conventional way.Type: GrantFiled: March 2, 1973Date of Patent: October 5, 1976Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Akio Fujii, Tomohisa Takita, Nobuyoshi Shimada
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Patent number: 3960834Abstract: By thermal decomposition of 3-(S,S-dimethylmercapto)propylaminobleomycin, there is easily obtained 3-(methylmercapto)propylaminobleomycin which is a useful antibiotic substance having an extremely high antimicrobial activity and a carcinostartic activity with low toxicity.Type: GrantFiled: November 2, 1973Date of Patent: June 1, 1976Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomohisa Takita, Akio Fujii, Hiroko Ito
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Patent number: 3953594Abstract: This invention is concerned with the oxidative conversion of an unstable phleomycin group to a stable bleomycin group antibiotic having the partial structure: ##SPC1##By treatment with potassium ferricyanide or manganese dioxide.Type: GrantFiled: August 7, 1973Date of Patent: April 27, 1976Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomohisa Takita, Yasuhiko Muraoka, Akio Fujii
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Patent number: RE30451Abstract: A novel process for producing antibiotics bleomycins by innoculating and aerobically culturing in a nutrient source-containing medium a bleomycin-producing strain belonging to the actinomyces, wherein the culture is effected in the presence of an amino compound having at least one ##STR1## group and at least one basic group selected from amino, imino, guanidino, amidino and sulfonium groups and nitrogen-containing cyclic compounds, or in the presence of a compound convertible in the culture liquor to such amino compound as mentioned above, thereby selectively producing a known or novel bleomycin component corresponding to the said amino compound or to an amino compound derived from the above-mentioned compound, and then the known or novel bleomycin is recovered by known means from the culture medium.Type: GrantFiled: May 24, 1979Date of Patent: December 16, 1980Assignee: Zaidan Jojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Kenji Maeda, Tomohisa Takita, Yuya Nakayama, Akio Fujii, Nobuyoshi Shimada, Hideo Chimura