Patents by Inventor Tomokazu Ogura

Tomokazu Ogura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing diarylpyridine derivatives
    Patent number: 11999724
    Abstract: The present invention relates to a novel method for producing diarylpyridine derivatives, and the object of the present invention is to provide a novel, industrially useful method. The present inventors developed a novel method for synthesizing pyridine rings without using palladium, a strong base, or a high-temperature reaction. In particular, they successfully developed a method that can be used to synthesize iminium salts as intermediates, synthesize cyano compounds from these iminium salts, and cyclize the cyano compounds into pyridines under very mild reaction conditions.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: June 4, 2024
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Yuichi Aki, Fumihiko Toriyama, Natsuki Sakurai, Ai Kameda, Tomokazu Ogura
  • NOVEL METHOD FOR PRODUCING ANTIBODY-IMMUNOSTIMULATOR CONJUGATE
    Publication number: 20240150390
    Abstract: The purpose of the present invention is to provide a novel stereoselective method for preparing a cyclic dinucleotide derivative and a production intermediate therefor, which can be used for an antibody-immunostimulant conjugate. Also provided is a method for producing a cyclic dinucleotide-linker and an antibody-immunostimulant conjugate while using the above production method. Further provided is a method for preparing a cyclic dinucleotide derivative, the method including the step of subjecting a compound (I) and a compound (IV) to stereoselective condensation using an optically active phosphitylating agent (Rc-II) or (Sc-II).
    Type: Application
    Filed: January 31, 2022
    Publication date: May 9, 2024
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Tomokazu OGURA, Takeshi NAKAYA, Hidekazu INOUE, Narumi ABE, Yuzo ABE, Tatsuya NAKAMURA, Yuko YAMAMOTO, Kohei SAKANISHI, Tatsuhiro SAKAMOTO, Satoshi NAKANE
  • METHOD OF PRODUCING 3-METHYL-4-HALO-INDOLE DERIVATIVE
    Publication number: 20230382856
    Abstract: The present inventors found a novel method for reducing formyl groups with the use of a Lewis acid and a hydride reducing agent in a production method for a 3-methyl-4-haloindole derivative. The present inventors also found that demethylation and/or dehalogenation of the derivative are suppressed by this method, making post-treatment easier or the derivative obtained at a high yield.
    Type: Application
    Filed: October 29, 2021
    Publication date: November 30, 2023
    Inventors: Natsuki SAKURAI, Tatsuhiro SAKAMOTO, Tomokazu OGURA
  • Method for Producing Diarylpyridine Derivatives
    Publication number: 20210188823
    Abstract: The present invention relates to a novel method for producing diarylpyridine derivatives, and the object of the present invention is to provide a novel, industrially useful method. The present inventors developed a novel method for synthesizing pyridine rings without using palladium, a strong base, or a high-temperature reaction. In particular, they successfully developed a method that can be used to synthesize iminium salts as intermediates, synthesize cyano compounds from these iminium salts, and cyclize the cyano compounds into pyridines under very mild reaction conditions.
    Type: Application
    Filed: July 3, 2019
    Publication date: June 24, 2021
    Inventors: Yuichi Aki, Fumihiko Toriyama, Natsuki Sakurai, Ai Kameda, Tomokazu Ogura