Patents by Inventor Tomokazu Yoshinaga

Tomokazu Yoshinaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10202404
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: February 12, 2019
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Tomokazu Yoshinaga, Kouhei Nodu
  • Publication number: 20180265525
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Application
    Filed: May 24, 2018
    Publication date: September 20, 2018
    Applicant: Shionogi & Co., Ltd.
    Inventors: Tomokazu YOSHINAGA, Kouhei NODU
  • Patent number: 10011613
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: July 3, 2018
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Tomokazu Yoshinaga, Kouhei Nodu
  • Publication number: 20170226128
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Application
    Filed: August 21, 2015
    Publication date: August 10, 2017
    Applicant: Shionogi & Co., Ltd.
    Inventors: Tomokazu YOSHINAGA, Kouhei NODU
  • Patent number: 7576198
    Abstract: A compound of the formula (I): wherein X is hydroxy or the like; Y is —C(?R2)—R3—R4 wherein R2 and R3 is oxygen atom or the like, R4 is hydrogen, optionally substituted alkyl, optionally substituted heteroaryl or the like; Z is hydrogen or the like; Z1 and Z3 each is independently a bond, alkylene or the like; Z2 is a bond, alkylene, —O— or the like; R1 is optionally substituted aryl, optionally substituted heteroaryl or the like; p is 0 to 2 and ring (A) is optionally substituted aromatic heterocycle, a tautomer of itself, a prodrug thereof, a pharmaceutically acceptable salt thereof or a solvate thereof has an integrase-inhibiting activity.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: August 18, 2009
    Assignee: Shionogi & Co., Ltd.
    Inventors: Takashi Kawasuji, Tomokazu Yoshinaga
  • Patent number: 7098201
    Abstract: A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wherein RB and RC each is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1 is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1 is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: August 29, 2006
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga, Akihiko Sato
  • Patent number: 6716605
    Abstract: A compound of the formula: wherein R1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like, R2 is hydrogen, lower alkyl, or optionally substituted aralkyl, or the like, R3, R4, R5, and R6 each is independently hydrogen, halogen, trihalogenated lower alkyl, or the like, X is hydroxy or optionally substituted amino, Y is COOR (R is hydrogen or an ester residue), optionally substituted aryl, or optionally substituted heteroaryl, has integrase inhibition activity, and is useful as an anti-HIV drug.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: April 6, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga
  • Publication number: 20040002485
    Abstract: A compound of the formula (I): 1
    Type: Application
    Filed: June 18, 2003
    Publication date: January 1, 2004
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga, Akihiko Sato
  • Patent number: 6645956
    Abstract: A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wherein RB and RC each is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1 is optionally substituted heteoaryl; provided that a compound wherein Y and/or A1 is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: November 11, 2003
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga, Akihiko Sato
  • Publication number: 20030181499
    Abstract: A compound of the formula: 1
    Type: Application
    Filed: September 30, 2002
    Publication date: September 25, 2003
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga
  • Patent number: 6620841
    Abstract: A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wherein RB and RC each is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1 is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1 is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: September 16, 2003
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga, Akihiko Sato
  • Patent number: 6506787
    Abstract: A compound of the formula: wherein R1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like, R2 is hydrogen, lower alkyl, or optionally substituted aralkyl, or the like, R3, R4, R5, and R6 each is independently hydrogen, halogen, trihalogenated lower alkyl, or the like, X is hydroxy or optionally substituted amino, Y is COOR (R is hydrogen or an ester residue), optionally substituted aryl, or optionally substituted heteroaryl, has integrase inhibition activity, and is useful as an anti-HIV drug.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: January 14, 2003
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga
  • Publication number: 20020019434
    Abstract: A compound of the formula: 1
    Type: Application
    Filed: August 15, 2001
    Publication date: February 14, 2002
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga
  • Patent number: 6333323
    Abstract: A compound of the formula: wherein R1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like, R2 is hydrogen, lower alkyl, or optionally substituted aralklyl, or the like, R3, R4, R5, and R6 each is independently hydrogen, halogen, trihalogenated lower alkyl, or the like, X is hydroxy or optionally substituted amino, Y is COOR R is hydrogen or an ester residue), optionally substituted aryl, or optionally substituted heteroaryl, has integrase inhibition activity, and is useful as an anti-HIV drug.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: December 25, 2001
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshio Fujishita, Tomokazu Yoshinaga