Patents by Inventor Tomoki OHKUBO

Tomoki OHKUBO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240076596
    Abstract: A cell culture container includes: an insert member having a membrane on which a cell is seeded, the insert member defining a first inner space that functions as an anaerobic chamber; a container having an attachment/detachment portion to and from which the insert member is attachable and detachable, the container defining a second inner space that functions as an aerobic chamber; a sealing member that closes an opening of the aerobic chamber between the attachment/detachment portion and the insert member with the insert member being attached to the attachment/detachment portion; and a transfer mechanism that transfers force to the sealing member. The sealing member closes the opening in response to an input of the force from the transfer mechanism.
    Type: Application
    Filed: October 14, 2021
    Publication date: March 7, 2024
    Inventors: Tsunehiro INOUE, Toyoyuki HASHIMOTO, Yasuko YONEDA, Kenji TAKUBO, Yoichi FUJIYAMA, Tomoki OHKUBO, Eiichi OZEKI, Ryogo TAKAI, Hiroomi GOTO, Sadamu TOMITA
  • Publication number: 20230313103
    Abstract: A cell culture container includes: a container body; a cell culture insert having a tubular portion and an oxygen-permeable membrane; and a lid member. The container body is provided with an opening that communicates with an interior of the container body. The tubular portion includes an upper end and a lower end, and is inserted in the opening such that the lower end is located inside the container body. The lower end side of the tubular portion is closed by the membrane. The upper end side of the tubular portion is closed by the lid member. The lid member includes a lower surface that faces toward an interior of the tubular portion. The lid member is provided with an electrode insertion port and a culture medium outlet port that each communicate with the interior of the tubular portion at the lower surface.
    Type: Application
    Filed: July 7, 2021
    Publication date: October 5, 2023
    Inventors: Tsunehiro INOUE, Toyoyuki HASHIMOTO, Yasuko YONEDA, Kenji TAKUBO, Yoichi FUJIYAMA, Tomoki OHKUBO, Eiichi OZEKI, Ryogo TAKAI, Hiroomi GOTO, Sadamu TOMITA
  • Publication number: 20230287326
    Abstract: A cell culture system includes: a cell culture container disposed in an anaerobic chamber; and an external apparatus. The external apparatus has a main body unit disposed in the anaerobic chamber and an operation unit disposed outside the anaerobic chamber. The main body unit is configured to perform a predetermined process onto the cell culture container. The operation unit is configured to transmit or receive a signal associated with the predetermined process to or from the main body unit by wireless communication.
    Type: Application
    Filed: May 31, 2021
    Publication date: September 14, 2023
    Inventors: Yasuko YONEDA, Tomoki OHKUBO, Toyoyuki HASHIMOTO
  • Publication number: 20230220323
    Abstract: A cell culture system includes: a first pump; and a first cell culture container and a second cell culture container. The first cell culture container has a first culture medium circulation flow path. The second cell culture container has a second culture medium circulation flow path independent of the first culture medium circulation flow path. The first culture medium circulation flow path and the second culture medium circulation flow path are fluidly connected to the first pump.
    Type: Application
    Filed: June 23, 2021
    Publication date: July 13, 2023
    Inventors: Toyoyuki HASHIMOTO, Kenji TAKUBO, Tsunehiro INOUE, Yasuko YONEDA, Tomoki OHKUBO
  • Patent number: 11193102
    Abstract: A cell culture apparatus includes an introduction-side flow path arranged to allow a culture solution introduced to flow therethrough and be introduced therethrough into each of a plurality of concave wells of a flexible strip circumferentially wound, and a first introduction-side seal provided on an outer circumferential side of the introduction-side flow path, the first introduction-side seal being configured to block flow of the culture solution from the introduction-side flow path to an outer circumferential side of the flexible strip.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: December 7, 2021
    Assignee: Shimadzu Corporation
    Inventor: Tomoki Ohkubo
  • Patent number: 11186810
    Abstract: A cell culture container includes a storage container, a cell culture area, a culture solution supply unit, and a discharge unit. The cell culture area is a region for culturing cells, and is provided in the storage container. The culture solution supply unit supplies the culture solution into the cell culture area at a flow rate equal to or less than a predetermined flow rate. The discharge unit discharges the liquid in the cell culture area to the outside of the storage container. A rectification unit is a structure in which a plurality of outflow ports are uniformly arranged in a direction perpendicular to the flow direction of the culture solution from the culture solution supply unit to the discharge unit.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: November 30, 2021
    Assignees: SHIMADZU CORPORATION, YOKOHAMA CITY UNIVERSITY, OSAKA UNIVERSITY, CORNING INCORPORATED
    Inventors: Tomoki Ohkubo, Masaki Kanai, Hirohisa Abe, Hideki Taniguchi, Masahiro Kinooka, Goro Kobayashi, Takanori Takebe
  • Patent number: 11174457
    Abstract: A cell culture apparatus includes a culturing unit having a surface provided with a plurality of concave wells for culturing cells therein, and a flow unit including a gas flow path which allows gas to flow therethrough. The culturing unit includes a gas permeator that is arranged to separate the plurality of wells from the flow unit, the gas permeator having oxygen permeability and liquid impermeability.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: November 16, 2021
    Assignee: Shimadzu Corporation
    Inventor: Tomoki Ohkubo
  • Publication number: 20210230529
    Abstract: A cell culture device (100) includes a band-shaped flexible member (10), the band-shaped member being configured to be circumferentially windable. The band-shaped member (10) has an inner circumferential surface (1a) and an outer circumferential surface (1b), at least one of which is provided with a plurality of wells (2) each having a concave shape, and at least some (2) of the plurality of wells (2) are connected to each other by a culture solution conduit (3).
    Type: Application
    Filed: May 29, 2019
    Publication date: July 29, 2021
    Applicant: SHIMADZU CORPORATION
    Inventor: Tomoki OHKUBO
  • Publication number: 20190376019
    Abstract: A cell culture apparatus includes an introduction-side flow path arranged to allow a culture solution introduced to flow therethrough and be introduced therethrough into each of a plurality of concave wells of a flexible strip circumferentially wound, and a first introduction-side seal provided on an outer circumferential side of the introduction-side flow path, the first introduction-side seal being configured to block flow of the culture solution from the introduction-side flow path to an outer circumferential side of the flexible strip.
    Type: Application
    Filed: June 6, 2019
    Publication date: December 12, 2019
    Inventor: Tomoki OHKUBO
  • Publication number: 20190376015
    Abstract: A cell culture apparatus includes a culturing unit having a surface provided with a plurality of concave wells for culturing cells therein, and a flow unit including a gas flow path which allows gas to flow therethrough. The culturing unit includes a gas permeator that is arranged to separate the plurality of wells from the flow unit, the gas permeator having oxygen permeability and liquid impermeability.
    Type: Application
    Filed: June 7, 2019
    Publication date: December 12, 2019
    Inventor: Tomoki OHKUBO
  • Publication number: 20190078044
    Abstract: A cell culture container includes a storage container, a cell culture area, a culture solution supply unit, and a discharge unit. The cell culture area is a region for culturing cells, and is provided in the storage container. The culture solution supply unit supplies the culture solution into the cell culture area at a flow rate equal to or less than a predetermined flow rate. The discharge unit discharges the liquid in the cell culture area to the outside of the storage container. A rectification unit is a structure in which a plurality of outflow ports are uniformly arranged in a direction perpendicular to the flow direction of the culture solution from the culture solution supply unit to the discharge unit.
    Type: Application
    Filed: March 16, 2016
    Publication date: March 14, 2019
    Applicants: Shimadzu Corporation, Yokohama City University, Osaka University, Kuraray Co., Ltd.
    Inventors: Tomoki OHKUBO, Masaki KANAI, Hirohisa ABE, Hideki TANIGUCHI, Masahiro KINOOKA, Goro KOBAYASHI, Takanori TAKEBE