Patents by Inventor Tomoki Tatefuji
Tomoki Tatefuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11089805Abstract: The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof.Type: GrantFiled: October 12, 2017Date of Patent: August 17, 2021Assignees: Yamada Bee Company, Inc., National University Corporation Kumamoto UniversityInventors: Shogo Misumi, Tomoki Ikuta, Tomoki Tatefuji, Hiroko Tani, Hiroshi Inooka
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Patent number: 10894067Abstract: Disclosed is a genome stability enhancer comprising, as an active ingredient, at least one member selected from the group consisting of enzyme-treated royal jelly, gnetum or its extract, and gnetin C.Type: GrantFiled: March 6, 2018Date of Patent: January 19, 2021Assignees: Yamada Bee Company, Inc., National Cancer Center, Tohoku UniversityInventors: Tomoki Ikuta, Shinobu Fukushima, Tomoki Tatefuji, Kenichi Yoshioka, Hitoshi Shirakawa
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Publication number: 20200093776Abstract: The present invention provides a mucosal immunostimulator comprising, as an active ingredient, at least one selected from the group consisting of saturated fatty acids represented by the following formula (1) and salts thereof: R—COOH??(1) wherein, in the formula (1), R represents an alkyl group having 7 to 11 carbon atoms substituted with one hydroxy group.Type: ApplicationFiled: September 27, 2019Publication date: March 26, 2020Inventors: Shogo MISUMI, Tomoki IKUTA, Tomoki TATEFUJI
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Patent number: 10570366Abstract: Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of Lactobacillus strain GG (ATCC53103), and a lower mitogenic activity and a lower IL-2 production inducing activity than those of Listeria strain EGD; and a food composition, a pharmaceutical composition, a cosmetic composition, an immunostimulant for preventing the infection by pathogens or viruses that invade through the respiratory or esophageal mucosa, and an intestinal immunostimulant for preventing or alleviating food poisoning, each of which contains the lactic acid bacterium or treated cells of the lactic acid bacterium.Type: GrantFiled: December 7, 2017Date of Patent: February 25, 2020Assignee: Yamada Bee Company Inc.Inventors: Daisuke Matsuura, Takashi Asama, Hironori Motoki, Tomoki Tatefuji, Ken Hashimoto
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Publication number: 20200023017Abstract: Disclosed is a genome stability enhancer comprising, as an active ingredient, at least one member selected from the group consisting of enzymatically degraded royal jelly, gnetum or its extract, and gnetin C.Type: ApplicationFiled: March 6, 2018Publication date: January 23, 2020Inventors: Tomoki Ikuta, Shinobu Fukushima, Tomoki Tatefuji, Kenichi Yoshioka, Hitoshi Shirakawa
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Publication number: 20190230967Abstract: The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof.Type: ApplicationFiled: October 12, 2017Publication date: August 1, 2019Applicant: National Unversity Corporation Kumamoto UniversityInventors: Shogo MISUMI, Tomoki IKUTA, Tomoki TATEFUJI, Hiroko TANI, Hiroshi INOOKA
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Publication number: 20180112176Abstract: Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of Lactobacillus strain GG (ATCC53103), and a lower mitogenic activity and a lower IL-2 production inducing activity than those of Listeria strain EGD; and a food composition, a pharmaceutical composition, a cosmetic composition, an immunostimulant for preventing the infection by pathogens or viruses that invade through the respiratory or esophageal mucosa, and an intestinal immunostimulant for preventing or alleviating food poisoning, each of which contains the lactic acid bacterium or treated cells of the lactic acid bacterium.Type: ApplicationFiled: December 7, 2017Publication date: April 26, 2018Inventors: Daisuke MATSUURA, Takashi ASAMA, Hironori MOTOKI, Tomoki TATEFUJI, Ken HASHIMOTO
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Publication number: 20180104205Abstract: The present invention provides a mucosal immunostimulator comprising, as an active ingredient, at least one selected from the group consisting of saturated fatty acids represented by the following formula (1) and salts thereof: R—COOH??(1) wherein, in the formula (1), R represents an alkyl group having 7 to 11 carbon atoms substituted with one hydroxy group.Type: ApplicationFiled: April 4, 2016Publication date: April 19, 2018Inventors: Shogo MISUMI, Tomoki IKUTA, Tomoki TATEFUJI
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Patent number: 9856451Abstract: Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of Lactobacillus strain GG (ATCC53103), and a lower mitogenic activity and a lower IL-2 production inducing activity than those of Listeria strain EGD; and a food composition, a pharmaceutical composition, a cosmetic composition, an immunostimulant for preventing the infection by pathogens or viruses that invade through the respiratory or esophageal mucosa, and an intestinal immunostimulant for preventing or alleviating food poisoning, each of which contains the lactic acid bacterium or treated cells of the lactic acid bacterium.Type: GrantFiled: December 25, 2012Date of Patent: January 2, 2018Assignee: Yamada Bee Company Inc.Inventors: Daisuke Matsuura, Takashi Asama, Hironori Motoki, Tomoki Tatefuji, Ken Hashimoto
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Publication number: 20140363880Abstract: Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of Lactobacillus strain GG (ATCC53103), and a lower mitogenic activity and a lower IL-2 production inducing activity than those of Listeria strain EGD; and a food composition, a pharmaceutical composition, a cosmetic composition, an immunostimulant for preventing the infection by pathogens or viruses that invade through the respiratory or esophageal mucosa, and an intestinal immunostimulant for preventing or alleviating food poisoning, each of which contains the lactic acid bacterium or treated cells of the lactic acid bacterium.Type: ApplicationFiled: December 25, 2012Publication date: December 11, 2014Applicant: Yamada Bee CompanyInventors: Daisuke Matsuura, Takashi Asama, Hironori Motoki, Tomoki Tatefuji, Ken Hashimoto
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Patent number: 8119839Abstract: The present invention provides a novel compound and antidepressant composition that can be effectively used for improving depressed mood and depressed state, particularly for depressed mood and depressed state in menopausal women. The compound of the present invention is represented by the following formula (1): wherein R1 and R2 are identical or different and represent a hydrogen atom, a hydroxyl group or an acetyloxy group, and n is an integer of 2 to 7, or a pharmaceutically acceptable salt or ester thereof. This compound is used as an active ingredient in the antidepressant composition. Examples of the compound of the invention include (2E)-9,10-dihydroxy-2-decenoic acid, (2Z)-9,10-dihydroxy-2-decenoic acid, (2E)-9-hydroxy-2-decenoic acid, and (2E)-7-acetoxy-2-heptenoic acid.Type: GrantFiled: July 19, 2008Date of Patent: February 21, 2012Assignee: Yamada Apiculture Center, Inc.Inventors: Hiroyuki Yoshimura, Kiyoshi Okihara, Satoshi Kawatake, Hiroko Tani, Tomoki Tatefuji, Ken Hashimoto, Hiromasa Tanaka, Akinori Inoue, Miyako Yanagihara
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Publication number: 20100184860Abstract: The present invention provides a novel compound and antidepressant composition that can be effectively used for improving depressed mood and depressed state, particularly for depressed mood and depressed state in menopausal women. The compound of the present invention is represented by the following formula (1): wherein R1 and R2 are identical or different and represent a hydrogen atom, a hydroxyl group or an acetyloxy group, and n is an integer of 2 to 7, or a pharmaceutically acceptable salt or ester thereof. This compound is used as an active ingredient in the antidepressant composition. Examples of the compound of the invention include (2E)-9,10-dihydroxy-2-decenoic acid, (2Z)-9,10-dihydroxy-2-decenoic acid, (2E)-9-hydroxy-2-decenoic acid, and (2E)-7-acetoxy-2-heptenoic acid.Type: ApplicationFiled: July 19, 2008Publication date: July 22, 2010Applicant: YAMADA APICULTURE CENTER, INC.Inventors: Hiroyuki Yoshimura, Kiyoshi Okihara, Satoshi Kawatake, Hiroko Tani, Tomoki Tatefuji, Ken Hashimoto, Hiromasa Tanaka, Akinori Inoue, Miyako Yanagihara
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Publication number: 20090148943Abstract: The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.Type: ApplicationFiled: November 5, 2008Publication date: June 11, 2009Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Makoto TAKEUCHI, Takanori Okura, Tomoki Tatefuji, Tetsuya Mori, Chikako Arai, Tsunetaka Ohta, Masashi Kurimoto
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Publication number: 20070110711Abstract: The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.Type: ApplicationFiled: October 19, 2006Publication date: May 17, 2007Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Makoto Takeuchi, Takanori Okura, Tomoki Tatefuji, Tetsuya Mori, Chikako Arai, Tsunetaka Ohta, Masashi Kurimoto
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Patent number: 5489577Abstract: Disclosed is a semi-solid pharmaceutical agent containing a stabilized proteinaceous bioactive substance prepared by successively mixing an oligosaccharide and an aqueous solution of a proteinaceous bioactive substance, and kneading the resultant solids with an oil or fat base. The pharmaceutical handles with ease because it is readily administered to the body through percutaneous and permucosal route which are safer and less in pain administration routes than other conventional administrations.Type: GrantFiled: June 28, 1994Date of Patent: February 6, 1996Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Masao Ikeda, Tomoki Tatefuji, Hiroshi Yamauchi