Abstract: There is provided an exhaust gas purifying catalyst including a substrate and catalyst portions. The substrate includes an inflow-side cells, outflow-side cells, and porous partition walls, each partition wall separating the inflow-side cell from the outflow-side cell. The catalyst portion includes: (group A) first catalyst portions, each first catalyst portion being provided on a surface of the partition wall that faces the inflow-side cell on an upstream side in an exhaust gas flow direction; and (group B) second catalyst portions being provided on a surface of the partition wall that faces the outflow-side cell on a downstream side in the exhaust gas flow direction. Each catalyst portion of one of group A and group B includes at least one oxidizing catalyst layer and at least one reducing catalyst layer, and each catalyst portion of the other of group A and group B includes at least one oxidizing catalyst layer and/or at least one reducing catalyst layer.

Abstract: An object of the present invention is to provide a novel method that enables determination or evaluation of the undifferentiated state of human pluripotent stem cells simply, efficiently and non-invasively. The present invention provides a method for determining or evaluating the undifferentiated state of human pluripotent stem cells, comprising a step of detecting or measuring fibronectin in a culture supernatant of human pluripotent stem cells.

Abstract: Provided is a method for producing an alkenyl phosphorus compound which can produce an alkenyl phosphorus compound efficiently even with a smaller amount of a catalyst used than that used conventionally, and further which can maintain catalytic activity to produce an alkenyl phosphorus compound in high yield even at a larger reaction scale, and which can also be applied to quantity synthesis at an industrial scale using a conventional batch reactor or continuous reactor. A method for producing an alkenyl phosphorus compound, comprising: a step of reacting a compound represented by the following formula (1): [In formula (1), R1 represents OR3 or R3, R2 represents OR4 or R4, and R3 and R4 represent, for example, each independently a substituted or unsubstituted alkyl group.] with a compound represented by the following formula (2): [In formula (2), R5 represents, for example, a hydrogen atom, or a substituted or unsubstituted alkyl group.

Abstract: Provided is a method for producing an alkenyl phosphorus compound which can produce an alkenyl phosphorus compound efficiently even with a smaller amount of a catalyst used than that used conventionally, and further which can maintain catalytic activity to produce an alkenyl phosphorus compound in high yield even at a larger reaction scale, and which can also be applied to quantity synthesis at an industrial scale using a conventional batch reactor or continuous reactor. A method for producing an alkenyl phosphorus compound, comprising: a step of reacting a compound represented by the following formula (1): [In formula (1), R1 represents OR3 or R3, R2 represents OR4 or R4, and R3 and R4 represent, for example, each independently a substituted or unsubstituted alkyl group.] with a compound represented by the following formula (2): R5—C?CH??(2) [In formula (2), R5 represents, for example, a hydrogen atom, or a substituted or unsubstituted alkyl group.

Abstract: The present invention provides a nitride semiconductor substrate having an initial nitride and a nitride semiconductor sequentially stacked on one principal plane of a base substrate, wherein the nitride semiconductor substrate comprises recesses depressed from an interface between the base substrate and the initial nitride toward the base substrate along one arbitrary cross section; the recesses each have a diameter of 6 nm or more and 60 nm or less and are formed at a density of 3×108 pieces/cm2 or more and 1×1011 pieces/cm2 or less; and the recess preferably has a depth of 3 nm or more and 45 nm or less from the interface between the base substrate and the initial nitride toward the base substrate.

Abstract: The present invention provides a nitride semiconductor substrate having an initial nitride and a nitride semiconductor sequentially stacked on one principal plane of a base substrate, wherein the nitride semiconductor substrate comprises recesses depressed from an interface between the base substrate and the initial nitride toward the base substrate along one arbitrary cross section; the recesses each have a diameter of 6 nm or more and 60 nm or less and are formed at a density of 3×108 pieces/cm2 or more and 1×1011 pieces/cm2 or less; and the recess preferably has a depth of 3 nm or more and 45 nm or less from the interface between the base substrate and the initial nitride toward the base substrate.

Abstract: There are provided a liquid preparation for oral administration which contains barium that is likely to be mixed with residues and is less likely to be precipitated in the intestinal tract, and a liquid preparation for oral administration and a composition for imaging a digestive tract which contain barium and enable the reduction of the dose of an intestinal tract cleaning solution in a the intestinal tract pretreatment. That is, there are provided an orally administered liquid preparation which contains barium and one or more types of thickening agents selected from the group consisting of a natural polysaccharide and a cellulose-based polymer, in which the viscosity at a shear rate of 21.54 s?1 is 100 mPa·s or greater and the viscosity at a shear rate of 464.1 s?1 is 5 mPa·s to 90 mPa·s, and the particle diameter D10 which is the particle diameter when the accumulation value in a volume cumulative distribution of the barium becomes 10% is 0.30 ?m to 0.80 ?m and the particle diameter D90 is 1.

Abstract: The present invention provides a solid cosmetic for lips that has excellent secondary adhesion resistance effect, excellent feeling in use, gloss durability, and excellent stability. The solid cosmetic for lips of the present invention is characterized by comprising the following (a) to (d): (a) 5 to 30 mass % of hydrogenated polyisobutene, (b) 30 to 70 mass % of one or more kinds of methyl phenyl silicones that separate from (a) when mixed therewith at 25° C., (c) 0.5 to 15 mass % of oil that separates from both (a) and (b) when mixed therewith at 25° C., and (d) 4 to 12 mass % of wax.

Abstract: The present invention provides a lip cosmetic that has excellent secondary adhesion resistance effect immediately after the application and is excellent in gloss and stability. The lip cosmetic of the present invention is characterized by comprising the following (a) and (b), wherein the blending quantity of (b) is 20 to 70 mass %: (a) 5 to 20 mass % of a polyglyceryl isostearate wherein the addition mole number of glycerin is 4 to 10, and the number of isostearic acid residues is 1 to 4; and (b) (b1) 20 to 70 mass % of a methyl phenyl silicone, (b2) 0 to 45 mass % of a pentaerythritol ester.

Abstract: An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.

Abstract: The present invention provides a lip cosmetic that has excellent secondary adhesion resistance effect immediately after the application and is excellent in gloss and stability. The lip cosmetic of the present invention is characterized by comprising the following (a) and (b), wherein the blending quantity of (b) is 20 to 70 mass %: (a) 5 to 20 mass % of a polyglyceryl isostearate wherein the addition mole number of glycerin is 4 to 10, and the number of isostearic acid residues is 1 to 4; and (b) (b1) 20 to 70 mass % of a methyl phenyl silicone, (b2) 0 to 45 mass % of a pentaerythritol ester.

Abstract: To provide means for improving tactile sensation of hair during application of a hair cosmetic composition, particularly a hair conditioner or a hair rinse, after washing of the hair. The present inventors have found that the object can be attained by a hair cosmetic composition containing the following ingredients (1) to (5): (1) a tertiary amine compound represented by formula (I) in an amount of 0.01 to 10 mass % with respect to the hair cosmetic composition: wherein R1 represents a C6 to C24 linear or branched alkyl group, A represents an amido or ether group, R2 represents a C2 to C4 alkylene group, or a C2 to C4 linear or branched hydroxyalkylene or hydroxyalkylenyl group, and R3 and R4, which are identical to or different from each other, each represent a hydrogen atom or a C1 to C3 linear or branched alkyl group; (2) a higher alcohol and/or a higher fatty acid in an amount of 0.

Abstract: To provide means for improving sensation of hair in application of a hair cosmetic composition, particularly a hair conditioner, after washing of the hair. The present inventors have found that the object can be attained by a hair cosmetic composition containing the following ingredients (1) to (4): (1) a hydroxyetheramine compound represented by formula (I) in an amount of 0.01 to 10 mass % with respect to the hair cosmetic composition: wherein R1 represents a C6 to C24 linear or branched alkyl group or alkenyl group, R2 represents a C2 to C6 linear or branched hydroxyalkylene or hydroxyalkylenyl group, and R3 and R4, which are identical to or different from each other, each represent a hydrogen atom or a C1 to C6 linear alkyl group; (2) a higher alcohol and/or a higher fatty acid in an amount of 0.1 to 20 mass % with respect to the hair cosmetic composition; (3) an organic acid having an aromatic ring skeleton; and (4) water.

Abstract: An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.

Abstract: Provided is a hair cosmetic that can exhibit hair styling capability, natural finishing capability, and hair style retentivity respectively at superior levels. The hair cosmetic contains a urethane-modified acrylic polymer having a structure in which a urethane polymer chain is bonded to an acrylic polymer chain through a linkage segment having a silicon-oxygen bond, in which the acrylic polymer chain is a residue of an acrylic polymer derived at least from an acrylic monomer (A) and a compound (B1) and/or a compound (B2), where the compound (B1) has a hydrolyzable silicon-containing group and an ethylenically unsaturated bond-containing group, and the compound (B2) has a hydrolyzable silicon-containing group and a mercapto group, and the urethane polymer chain is a residue of a urethane polymer (C) having a hydrolyzable silicon-containing group. The linkage segment in the urethane-modified acrylic polymer is preferably a silicone polymer chain.

Abstract: An object of the present invention is to provide a method for inducing the differentiation of and/or promoting the proliferation of regulatory T cells, an immunosuppressive method using these methods, and pharmaceutical compositions for use in these methods. Furthermore, a method for inducing the differentiation of and/or promoting the proliferation of regulatory T cells and a method for immunosuppression using such methods are provided, which involve causing an agonist of a GIP anchored protein to act on T cells expressing the GIP anchored protein.

Abstract: An object of the present invention is to provide a method for inducing differentiation and/or promoting proliferation of regulatory T cells, a method for suppressing the transendothelial cell migration of immunocytes, a method for suppressing immunity using these methods, and a pharmaceutical composition to be used for these methods. Provided are a method for inducing differentiation and/or promoting proliferation of regulatory T cells by causing CD52 agonists, including anti-CD52 antibodies, to act on CD52-expressing T cells, a method for suppressing the transendothelial cell migration of immunocytes, and a method for suppressing immunity using these methods.

Abstract: The present invention provides a pharmaceutical composition for treatment and prevention of bleeding disorders caused by platelet disorders, not caused by defect in blood coagulation factors or von Willebrand Factor but caused by reduction of circulating platelet count or platelet dysfunction, said composition comprising a hemostatic effective amount of Factor VIII and/or von Willebrand Factor. Also provided is a method for treating said bleeding, comprising administering a hemostatic effective amount of Factor VIII and/or von Willebrand Factor to patients suffering from bleeding disorders caused by platelet disorders.

Abstract: The present invention relates to novel isoxazole and thiazole compounds having an excellent lysophosphatidic acid (LPA) receptor antagonistic activity represented by general formula [1] or salts thereof: wherein R1 and R2 represents an optionally substituted alkyl group or the like; R3 represents a hydrogen atom or the like; R4 represent a group selected from the group consisting of (I) optionally substituted phenyl, aryl, or heterocycle, (II) substituted or nonsubstituted alkyl, and (III) substituted or nonsubstituted alkenyl, alternatively, R3 and R4 may form a ring structure together with a carbon atom to which they bind; and X represents an oxygen atom or a sulfur atom, provided that, when R3 is a hydrogen atom, R4 represents a group other than methyl, and the use thereof as a medicine.

Abstract: The present invention provides a pharmaceutical composition for treatment and prevention of hemorrhage associated with blood coagulation disorders, comprising activated Factor VII (FVIIa) and Factor X (FX) as an active ingredient. The pharmaceutical composition of the present invention contains no components causative side effects, is safe, highly efficacious, and easy to manage hemostasis. The pharmaceutical composition can be used for hemostatic management of patients suffering from hemorrhage associated with blood coagulation disorders, for example, disorders (including deficiency) of blood coagulation factors, especially caused by inhibitors (antibodies) against blood coagulation factors.