Patents by Inventor Tomoko Yasugi

Tomoko Yasugi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEASE-ACTIVATED CYTOKINE
    Publication number: 20240270806
    Abstract: The present invention relates to fusion proteins or protein complexes comprising a ligand binding moiety fused to a ligand moiety, wherein the ligand binding moiety comprises an IL-12 binding domain and a protease cleavage site that, when activated by cleavage by a protease, restores biological activity of the ligand moiety, wherein the ligand moiety is an IL-12 fusion protein. The invention also relates to a polypeptide representing a mutated p40 subunit of IL-12, and to an IL-12 fusion protein or a protein complex comprising the mutated p40 subunit. The invention also relates to anti-IL-12 binding molecule or anti-IL-12 binding molecule complex defined by its variable light and heavy chains. The invention also relates to polynucleotides encoding the fusion proteins or fusion protein complexes or polypeptides or binding molecules, to methods of producing same, to their uses and pharmaceutical compositions comprising same.
    Type: Application
    Filed: January 17, 2024
    Publication date: August 15, 2024
    Inventors: Vishnu Priyanka Reddy CHICHILI, Tomoyuki IGAWA, Yohei YAMAMOTO, Naoka HIRONIWA, Takeru NAMBU, Tatsuya KAWA, Hitoshi KATADA, Tomoko YASUGI, Masahiro AZUMA
  • Hyaluronic acid derivative having amino acid and steryl group introduced thereinto
    Patent number: 11564971
    Abstract: The present invention provides a hyaluronic acid derivative containing a disaccharide unit represented by formula (I) or formula (I) and (II), and a complex containing the hyaluronic acid derivative and a drug.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: January 31, 2023
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takashi Nakai, Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tsuyoshi Shimoboji
  • Derivative of hyaluronic acid modified with amino-carboxylic acid
    Patent number: 9243077
    Abstract: The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: January 26, 2016
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tai Hirakura, Tsuyoshi Shimoboji
  • HYALURONIC ACID DERIVATIVE HAVING AMINO ACID AND STERYL GROUP INTRODUCED THEREINTO
    Publication number: 20150231268
    Abstract: The present invention provides a hyaluronic acid derivative containing a disaccharide unit represented by formula (I) or formula (I) and (II), and a complex containing the hyaluronic acid derivative and a drug.
    Type: Application
    Filed: September 5, 2013
    Publication date: August 20, 2015
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takashi Nakai, Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tsuyoshi Shimoboji
  • DERIVATIVE OF HYALURONIC ACID MODIFIED WITH AMINO-CARBOXYLIC ACID
    Publication number: 20130338352
    Abstract: The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 19, 2013
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tomoko Yasugi, Yoshihiro Tampo, Kenji Yasugi, Tai Hirakura, Tsuyoshi Shimoboji