Patents by Inventor Tomomi Ikemoto
Tomomi Ikemoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230088365Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: October 7, 2022Publication date: March 23, 2023Inventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
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Patent number: 11498898Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: September 15, 2020Date of Patent: November 15, 2022Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
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Publication number: 20210070705Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: September 15, 2020Publication date: March 11, 2021Inventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
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Patent number: 10844011Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: November 22, 2019Date of Patent: November 24, 2020Assignee: Takeda Pharmaceutical Company LimitedInventors: Toshiaki Nagata, Naohiro Fukuda, Tomomi Ikemoto
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Publication number: 20200115336Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: November 22, 2019Publication date: April 16, 2020Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Patent number: 10538489Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: November 26, 2018Date of Patent: January 21, 2020Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Naohiro Fukuda
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Publication number: 20190127324Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: November 26, 2018Publication date: May 2, 2019Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Patent number: 10173977Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: January 13, 2016Date of Patent: January 8, 2019Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Patent number: 10174004Abstract: The present invention provides an industrially advantageous method of producing a pyridazinone compound. The present invention relates to the following method of producing a pyridazinone compound: Formula (II), (IIIa), (IV) or (IV?), Formula (IIIb), (Vb) or (V?b), Formula (VI), (I) or (I?), wherein each symbol is as described in the specification.Type: GrantFiled: February 20, 2014Date of Patent: January 8, 2019Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Naohiro Fukuda, Tomomi Ikemoto
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Publication number: 20180009746Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: January 13, 2016Publication date: January 11, 2018Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Patent number: 9266831Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: June 12, 2014Date of Patent: February 23, 2016Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Toshiaki Nagata, Naohiro Fukuda
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Publication number: 20160002209Abstract: The present invention provides an industrially advantageous method of producing a pyridazinone compound. The present invention relates to the following method of producing a pyridazinone compound: Formula (II), (IIIa), (IV) or (IV?), Formula (IIIb), (Vb) or (V?b), Formula (VI), (I) or (I?), wherein each symbol is as described in the specification.Type: ApplicationFiled: February 20, 2014Publication date: January 7, 2016Applicant: Takeda Pharmaceutical Company LimitedInventors: Naohiro FUKUDA, Tomomi IKEMOTO
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Publication number: 20140303378Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: June 12, 2014Publication date: October 9, 2014Inventors: Tomomi IKEMOTO, Hideya MIZUFUNE, Toshiaki NAGATA, Misayo SERA, Naohiro FUKUDA, Takeshi YAMASAKI
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Patent number: 8822694Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: February 24, 2010Date of Patent: September 2, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda
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Publication number: 20110306769Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: February 24, 2010Publication date: December 15, 2011Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Patent number: 7521545Abstract: A process for the production of an aromatic azo compound having a 2,3-dihydrobenzofuran ring bearing a diazo group at the 5-position of the ring by conducting the diazo coupling of a 2,3-dihydrobenzofuran derivative represented by the general formula (II): [wherein R1 and R2 are each independently C1-6 alkyl; R3 is optionally substituted aryl; and R4, R5 and R6 are each independently hydrogen, C1-6 alkyl, halogeno, C1-6 alkoxy, or C1-6 alkylthio] with a benzenediazonium salt having an electron-withdrawing group at the p- and/or o-position in a mixed solvent composed of water and a polar organic solvent.Type: GrantFiled: August 25, 2005Date of Patent: April 21, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Takeshi Yamasaki
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Publication number: 20090054655Abstract: The present invention provides a method for producing an organic oxide, wherein a substrate is oxidized using hypohalous acid, hypohalous acid salt, chlorine, bromine or iodine in the presence of water and a catalytic amount of a compound represented by the following formula (I): R1—X1—NY—R2, wherein: X1 represents —CO— or —SO2—; Y represents a hydrogen atom, a potassium atom, a sodium atom, a chlorine atom, a bromine atom or an iodine atom; R1 represents a substituted or unsubstituted hydrocarbon group, —NYR3 group or —OR3 group (in the formulae, R3 represents a substituted or unsubstituted hydrocarbon group, and Y represents the same meaning as defined above); and R2 represents a hydrogen atom or —CO—R4 group (in the formula, R4 represents a substituted or unsubstituted hydrocarbon group, —NYR5 group or —OR5 group (in the formulae, R5 represents a substituted or unsubstituted hydrocarbon group, and Y represents the same meaning as defined above)); or R1 and R4 may bind to each other to form a further substiType: ApplicationFiled: April 5, 2007Publication date: February 26, 2009Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Tomomi Ikemoto, Naohiro Fukuda
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Publication number: 20080009539Abstract: A process for the production of an aromatic azo compound having a 2,3-dihydrobenzofuran ring bearing a diazo group at the 5-position of the ring by conducting the diazo coupling of a 2,3-dihydrobenzofuran derivative represented by the general formula (II): [wherein R1 and R2 are each independently C1-6 alkyl; R3 is optionally substituted aryl; and R4, R5 and R6 are each independently hydrogen, C1-6 alkyl, halogeno, C1-6 alkoxy, or C1-6 alkylthio] with a benzenediazonium salt having an electron-withdrawing group at the p- and/or o-position in a mixed solvent composed of water and a polar organic solvent.Type: ApplicationFiled: August 25, 2005Publication date: January 10, 2008Inventors: Tomomi Ikemoto, Takeshi Yamasaki
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Publication number: 20070099986Abstract: A compound represented by the formula: wherein Ar represents a group represented by the formula: (wherein Y represents methylene or an oxygen atom, R1 represents aminosulfonyl, C1-6 alkylaminosulfonyl, C1-6 alkylcarbonylamino or C1-6 alkylsulfonylamino, R2 represents a hydrogen atom or C1-6 alkyl, R3 represents C1-6 alkyl, and R4 represents a hydrogen atom or C1-6 alkyl); X represents a carbonyl group, or a methylene group which may be substituted with a hydroxy group; and L represents an optionally substituted C4-5 alkylene group, or a salt thereof is provided.Type: ApplicationFiled: October 31, 2006Publication date: May 3, 2007Inventors: Yuji Ishichi, Koichi Iwanaga, Tomomi Ikemoto, Hiroaki Yamamoto, Shokyo Miki
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Patent number: 7038042Abstract: A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula: {wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; R3 represents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then —X—CH2-Z is not —X1—X2—CH2, -Z (wherein X1 represents sulfur or optionally substituted nitrogen and X2 represents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof: (wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.Type: GrantFiled: December 10, 2004Date of Patent: May 2, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu