Abstract: This invention provides a cell culture substrate comprising on its surface a fluorine-containing polymer that enables three-dimensional tissue culture. The cell culture substrate of the invention has a surface at least a part of which is composed of a resin composition comprising a fluorine-containing polymer having one or more fluorine atoms in a repeating unit and exhibits the oxygen gas permeability of 219 cm3 (STP)/(m2·24 h·atm) or higher. Three-dimensional tissue can be formed via cell culture with the use of the cell culture substrate of the invention.

Abstract: Provided are a method for producing undifferentiated cell spheroids, the method comprising the step of culturing undifferentiated cells on a cell-adhesive surface of a cell culture sheet; a method for maintaining cell spheroids in an undifferentiated state, the method comprising the step of culturing undifferentiated cell spheroids on a cell-adhesive surface of a cell culture sheet; and a cell spheroid obtained by the method.

Abstract: To provide a spheroid-containing cell preparation exhibiting a high therapeutic effect for a cartilage tissue-related disorder as a treatment target. A prophylactic or therapeutic agent for a cartilage tissue-related disorder contains, as an effective ingredient, a spheroid including cultured mesenchymal stem cells.

Abstract: The present invention provides a cell culture sheet comprising a plurality of recesses each having an opening of 1000 ?m or less in diameter, wherein each recess has an inner circumferential face and a bottom face, wherein the inner circumferential face has a non-cell adhesive surface, and wherein the bottom face has a cell-adhesive surface; and a method for producing a cell culture sheet, the method comprising laminating of a layer having a non-cell adhesive surface and a layer having a cell-adhesive surface, wherein the layer having a non-cell adhesive surface has a plurality of through-holes of 1000 ?m or less in diameter. The cell culture sheet of the present invention can be prepared simply and assists efficient cell culture operation, and therefore can preferably be used in the field of cell-based pharmaceutical preparations, for example, spheroid-containing pharmaceutical preparations etc.

Abstract: To provide a spheroid-containing cell preparation exhibiting a high therapeutic effect for a cartilage tissue-related disorder as a treatment target. A prophylactic or therapeutic agent for a cartilage tissue-related disorder contains, as an effective ingredient, a spheroid including cultured mesenchymal stem cells.

Abstract: This invention provides a cell culture substrate comprising on its surface a fluorine-containing polymer that enables three-dimensional tissue culture. The cell culture substrate of the invention has a surface at least a part of which is composed of a resin composition comprising a fluorine-containing polymer having one or more fluorine atoms in a repeating unit and exhibits the oxygen gas permeability of 219 cm3 (STP)/(m2·24 h·atm) or higher. Three-dimensional tissue can be formed via cell culture with the use of the cell culture substrate of the invention.

Abstract: The invention aims to provide a method by which a solution of polyimide can be easily obtained. Further, the invention aims to provide a fluorinated polyimide solution by which fluorinated polyimide excellent especially as an optical material and an electronic functional material can easily be produced. The production method of the soluble polyimide solution according to invention is characterized by mixing a mixture containing a polyamide acid, a cyclodehydration reagent, and a solvent by a rotation-revolution mixing method. Further, the fluorinated polyimide solution of the invention is a solution of polyimide defined by the following formula (II): wherein, X and Y independently represent divalent organic groups; Z represents chlorine atom, bromine atom, or iodine atom; p represents an integer of 1 to 3; q represents an integer of 0 to 2; and p+q=3.

Abstract: An optical waveguide substrate with an optical fiber fixation groove, including an optical waveguide which contains a lower cladding layer on a base substrate, wherein the lower cladding layer has an optical fiber fixation groove and a core groove, and a weir is provided between the optical fiber fixation groove and the core groove. The optical waveguide substrate with an optical fiber fixation groove is produced by forming a lower cladding layer on a base substrate using a male stamp produced from a female stamp and then successively forming a core layer and an upper cladding layer thereon.

Abstract: Provided are a polyimide which is inexpensive, has various excellent material properties including strength, heat resistance, low moisture absorption, mold releasability (detachability), dielectric properties, electrical properties, and optical properties, and can exhibit a high level of water repellency, and a polyamic acid composition useful as a raw material therefor. Also provided are the polyimide which can give a polyimide composition that, besides having such excellent material properties, is capable of having a controlled surface resistivity, and a polyamic acid composition useful as a raw material therefor.

Abstract: The invention provides a flexible optical waveguide in which an optical waveguide film is directly formed on a substrate without using an adhesive and which is excellent in flexibility of the optical waveguide film, including the substrate, and excellent in adhesiveness between the substrate and the optical waveguide film, as well as a process for producing the flexible optical waveguide in a simple and easy manner. The flexible optical waveguide includes a lower cladding layer, a core layer, and an upper cladding layer successively formed on a substrate and a surface of the substrate, on which surface the lower cladding layer is to be formed, has an arithmetic average roughness (Ra) of 0.03 ?m or higher.

Abstract: In an optical waveguide, the present invention provides a process for producing an optical waveguide, and a stamp for use in the production process, in which the thickness of a lower cladding layer in the portion positioned in the lower side of a core layer is easily controlled even if any one or more materials of a substrate, a cladding material, and a stamp are material with low rigidity. The production process of the present invention comprises steps of forming a lower cladding layer which has a core groove and spacer grooves formed substantially in parallel with intervals in both sides of the core groove on a substrate by making use of soft lithography with a second stamp (i.e.

Abstract: The invention aims to provide a method by which a solution of polyimide can be easily obtained. Further, the invention aims to provide a fluorinated polyimide solution by which fluorinated polyimide excellent especially as an optical material and an electronic functional material can easily be produced. The production method of the soluble polyimide solution according to invention is characterized by mixing a mixture containing a polyamide acid, a cyclodehydration reagent, and a solvent by a rotation-revolution mixing method. Further, the fluorinated polyimide solution of the invention is a solution of polyimide defined by the following formula (II): wherein, X and Y independently represent divalent organic groups; Z represents chlorine atom, bromine atom, or iodine atom; p represents an integer of 1 to 3; q represents an integer of 0 to 2; and p+q=3.

Abstract: The present invention provides a flexible optical waveguide in which at least one of a lower cladding layer, a core layer, and an upper cladding layer is composed of an epoxy film formed using an epoxy resin composition containing a polyglycidyl compound having a polyalkylene glycol chain(s) and at least two glycidyl groups or an epoxy film having a glass transition temperature (Tg) of 100° C. or lower, a process for its production, and an epoxy resin composition for flexible optical waveguides.

Abstract: An optical waveguide substrate with an optical fiber fixation groove, including an optical waveguide which contains a lower cladding layer on a base substrate, wherein the lower cladding layer has an optical fiber fixation groove and a core groove, and a weir is provided between the optical fiber fixation groove and the core groove. The optical waveguide substrate with an optical fiber fixation groove is produced by forming a lower cladding layer on a base substrate using a male stamp produced from a female stamp and then successively forming a core layer and an upper cladding layer thereon. The stamp for use in such a production process includes concave portions or convex portions, corresponding to the optical fiber fixation groove and the core groove, as well as a convex portion or a concave portion corresponding to the weir. An opto-electronic hybrid integrated module includes the optical waveguide substrate with an optical fiber fixation groove.

Abstract: The invention provides a flexible optical waveguide in which an optical waveguide film is directly formed on a substrate without using an adhesive and which is excellent in flexibility of the optical waveguide film, including the substrate, and excellent in adhesiveness between the substrate and the optical waveguide film, as well as a process for producing the flexible optical waveguide in a simple and easy manner. The flexible optical waveguide includes a lower cladding layer, a core layer, and an upper cladding layer successively formed on a substrate and a surface of the substrate, on which surface the lower cladding layer is to be formed, has an arithmetic average roughness (Ra) of 0.03 ?m or higher.

Abstract: A halogenated polyamide acid composition containing a halogenated polyamide acid, a metal oxide precursor, a catalyst of reaction of generating a metal oxide from the precursor, and/or a coupling agent having a reactive group. A halogenated polyimide film is obtained by, for example, carrying out the heat treatment of the halogenated polyamide acid composition. The halogenated polyimide film has a refractive index at wavelength of, for example, 1,550 nm of 1.520 or lower. Further, an optical waveguide uses the halogenated polyimide film as at least one of a core layer and a clad layer, and a relative refractive index difference between the core layer and the clad layer of the optical waveguide is, for example, 0.6 or greater. An optical waveguide device contains such an optical waveguide.

Abstract: A halogenated polyamide acid composition containing a halogenated polyamide acid, a metal oxide precursor, a catalyst of reaction of generating a metal oxide from the precursor, and/or a coupling agent having a reactive group. A halogenated polyimide film is obtained by, for example, carrying out the heat treatment of the halogenated polyamide acid composition. The halogenated polyimide film has a refractive index at wavelength of, for example, 1,550 nm of 1.520 or lower. Further, an optical waveguide uses the halogenated polyimide film as at least one of a core layer and a clad layer, and a relative refractive index difference between the core layer and the clad layer of the optical waveguide is, for example, 0.6 or greater. An optical waveguide device contains such an optical waveguide.

Abstract: A fluorinated polyamide acid resin composition for optical materials containing a fluorinated polyamide acid and a non-polycondensable compound (A) with an aromatic ring having a boiling point of 340° C. or lower, the resin composition being used for obtaining a fluorinated polyimide membrane by a baking process. This fluorinated polyamide acid resin composition for optical materials contains a non-polycondensable compound (A) which was found to reduce a light absorption at 1.49 ?m and a light absorption at 1.35 ?m and extending to visible light, even if the baking temperature is 340° C. or lower.

Abstract: The present invention provides: a transparent heat-resistant resin that has a small amount of both the residual maleimide monomer and the maleimide monomer generated by heating in order to carry out such as a mold processing, and further, is excellent in heat resistance and yellowish little; a production process therefor; and a resin composition utilizing this resin. The transparent heat-resistant resin, according to the present invention, is obtained by a process including the step of running a polymerization of comonomers including a maleimide monomer and a methacrylic acid ester monomer, wherein the amount of the residual maleimide monomer in the resin is not more than 10× ppm when the amount of a structural unit derived from the maleimide monomer is X weight % in the resin, and the amount of the generated maleimide monomer by heating the resin at 240° C.