Patents by Inventor Tomomi Sumida

Tomomi Sumida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL EPITOPE AND MECHANISM OF ANTIGEN-ANTIBODY INTERACTION IN AN INFLUENZA VIRUS
    Publication number: 20140086927
    Abstract: Antibodies (Abs) play roles in protection against influenza. Neutralizing Abs either inhibit the binding of hemagglutinin (HA) to cellular receptors or prevent the conformational change of HA induced by low pH. The former Ab binds to the regions near the sialic acid-binding pocket on the globular head formed by HA1 and generally shows narrow strain specificity. The latter Ab binds to the stem region formed mainly by HA2 and shows broad strain specificity. We isolated a broadly neutralizing Ab against H3N2 viruses. X-ray analysis of the HA/Ab complex indicated that the Ab binds to the valley formed by two neighboring HA monomers at the side of the globular head. The Ab shows neutralizing activity by preventing the conformational change of HA induced at low pH.
    Type: Application
    Filed: September 24, 2013
    Publication date: March 27, 2014
    Applicants: Fujita Health University, The Research Foundation for Microbial Diseases of Osaka University, Osaka University
    Inventors: Yoshikazu Kurosawa, Yoshitaka Iba, Nobuko Ohshima, Shigeyuki Yokoyama, Mikako Shirouzu, Yoshifumi Fujii, Tomomi Sumida, Kazuyoshi Ikuta, Shota Nakamura, Norihito Kawashita, Mitsuhiro Nishimura, Akifumi Yamashita, Yoshinobu Okuno, Ritsuko Kubota-Koketsu, Masahiro Okubo