Patents by Inventor Tomomichi Yoshida

Tomomichi Yoshida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for production of cis-4-fluoro-L-proline derivatives
    Patent number: 7279584
    Abstract: The present invention provides a safer method for production of a cis-4-fluoro-L-proline derivative under milder conditions and in good yield to give a product of high purity on an industrial scale at low cost. Namely, the present invention provides a method for producing a cis-4-fluoro-L-proline derivative, which comprises reacting a trans-4-hydroxy-L-proline derivative of the following Formula [I]: (wherein R1 represents a protecting group for an ?-amino group, and R2 represents a protecting group for a carboxyl group) with N,N-diethyl-N-(1,1,2,3,3,3-hexafluoropropyl)amine in the presence of a hydrogen fluoride-scavenger.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: October 9, 2007
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Kazuyuki Tomisawa, Dai Tatsuta, Tomomichi Yoshida, Chihiro Yokoo
  • Process for production of cis-4-fluoro-l-proline derivatives
    Publication number: 20060281927
    Abstract: The present invention provides a safer method for production of a cis-4-fluoro-L-proline derivative under milder conditions and in good yield to give a product of high purity on an industrial scale at low cost. Namely, the present invention provides a method for producing a cis-4-fluoro-L-proline derivative, which comprises reacting a trans-4-hydroxy-L-proline derivative of the following Formula [I]: (wherein R1 represents a protecting group for an ?-amino group, and R2 represents a protecting group for a carboxyl group) with N,N-diethyl-N-(1,1,2,3,3,3-hexafluoropropyl)amine in the presence of a hydrogen fluoride-scavenger.
    Type: Application
    Filed: August 18, 2004
    Publication date: December 14, 2006
    Inventors: Kazuyuki Tomisawa, Dai Tatsuta, Tomomichi Yoshida, Chihiro Yokoo
  • Process for preparing erythromycin A oxime or a salt thereof
    Patent number: 5274085
    Abstract: A process for preparing erythromycin A oxime or a salt thereof which comprises reacting erythromycin A with hydroxylamine using an acid, is disclosed. Erythromycin A oxime and the salts thereof are useful as intermediates for the synthesis of macrolide antibiotics.
    Type: Grant
    Filed: May 12, 1989
    Date of Patent: December 28, 1993
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Takehiro Amano, Masami Goi, Kazuto Sekiuchi, Tomomichi Yoshida, Masahiro Hasegawa